Key Players in the Regulation of Fungal Secondary Metabolism

  • Benjamin P. KnoxEmail author
  • Nancy P. Keller
Part of the Fungal Biology book series (FUNGBIO)


Secondary metabolites (SMs) produced by filamentous fungi are well known for having a broad range of bioactivities that have detrimental, as well as beneficial, impacts on human affairs. With the grouping of SM biosynthetic genes into clusters it is possible for regulatory elements, such as individual transcription factors or multiprotein complexes, to modulate metabolite expression individually or at a larger, more global scale. In this chapter, we survey some key transcriptional players in the regulation of secondary metabolism including cluster-specific Zn(II)2Cys6, Cys2His2, and winged helix proteins, bZIP factors associated with stress and SM, environmental monitoring Cys2His2 proteins (AreA, CreA, and PacC) and two global regulatory complexes—the velvet complex and the CCAAT-binding complex.


Secondary metabolism Mycotoxins Transcriptional regulation Natural products Filamentous fungi 


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Medical Microbiology and ImmunologyUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.Department of Medical Microbiology and Immunology, Department of BacteriologyUniversity of Wisconsin-MadisonMadisonUSA

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