Fungal Secondary Metabolites in the “OMICS” Era

  • Susanne ZeilingerEmail author
  • Carlos García-Estrada
  • Juan-Francisco Martín
Part of the Fungal Biology book series (FUNGBIO)


Secondary metabolites produced by fungi have a tremendous impact on the human society; some are exploited for their antibiotic and pharmaceutical activities, others are involved in disease interactions with other organisms such as plants or animals.

The Springer book series on fungal biology includes two volumes on the Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites accommodating the importance of these substances and the tremendous progress in the research on fungal secondary metabolism during recent years. While the first volume was published in 2014, you now have the second volume in your hand. In this introductory chapter, we bridge volume I—which covers the best-studied fungal secondary metabolites such as the penicillin and cephalosporin antibiotics, the immunosuppressive cyclosporine A, the anticholesterolemic agents lovastatin and compactin, the mycotoxins aflatoxin, ochratoxin A, roquefortine C, gibberellins, fusarins, fusaric acid and ergot alkaloids, the carotenoid, xanthophyll, bikaverin and fusarubin pigments, the pyripyropene meroterpenoids, and the iron-chelating siderophores—with other important aspects of secondary metabolites comprised in the second volume. Articles in the latter cover the spectrum from key transcriptional players in the regulation of secondary metabolite biosynthesis and its epigenetic control to approaches for the detection of new gene clusters and substances by genome mining, metagenomics/metatranscriptomics and metabolomics to the use of secondary metabolite profiles in fungal chemotaxonomy. Further reviews deal with the still underexplored fungal endophytes as a reservoir of novel biologically active natural products, the role of secondary metabolites in the interaction of fungi with plants and animals, and with a special group of fungal peptide secondary metabolites, the peptaibols.


Fungal secondary metabolism Biosynthesis Gene cluster Genome Transcriptomics Metabolomics 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Susanne Zeilinger
    • 1
    • 2
    Email author
  • Carlos García-Estrada
    • 3
  • Juan-Francisco Martín
    • 4
  1. 1.Institute of Chemical EngineeringVienna University of TechnologyWienAustria
  2. 2.Institute of MicrobiologyUniversity of InnsbruckInnsbruckAustria
  3. 3.INBIOTEC (Instituto de Biotecnología de León)LeónSpain
  4. 4.Department of Molecular Biology, Microbiology SectionUniversity of LeónLeónSpain

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