• Connie M. Wu
  • Annie M. Wu
  • Jenna Lester
  • Leslie Robinson-Bostom


Xerosis cutis is among the most frequent skin disorders associated with chronic renal failure, with an overall frequency of 75 % among renal dialysis patients. Several factors have been implicated in the development of uremic xerosis, including progressive shrinkage of eccrine sweat glands and atrophy of sebaceous glands. Xerosis predominantly affects extensor surfaces of forearms, legs, and thighs, and can present with pruritus although it has a distinct pathophysiology. Severe cases may exhibit scaling, desquamation, and fissures. A complete history, full skin exam, and thyroid exam are integral to the diagnosis of xerosis. Certain emollients and drugs are effectively used in the treatment of xerosis and result in significant improvements in quality of life.


Xerosis Uremic xerosis Uremic pruritus Ichthyosis Dermatitis Hemodialysis Emollients End stage renal disease Chronic kidney disease 


Conflicts of Interest

C.M.W., A.M.W., J.L., and L.R.B. report no conflicts of interest.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Connie M. Wu
    • 1
  • Annie M. Wu
    • 2
  • Jenna Lester
    • 3
  • Leslie Robinson-Bostom
    • 4
  1. 1.Department of DermatologyWarren Alpert Medical School of Brown UniversityProvidenceUSA
  2. 2.Department of DermatologyWarren Alpert Medical School of `ProvidenceUSA
  3. 3.Department of DermatologyWarren Alpert Medical School of Brown UniversityProvidenceUSA
  4. 4.Division of Dermatopathology, Department of Dermatology, Rhode Island HospitalThe Warren Alpert Medical School of Brown UniversityProvidenceUSA

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