Abstract
The ideal timing for the treatment of fractures remains controversial. In general, earlier treatment of fractures is advantageous because it facilitates mobilization of the patient, decreases the pain and systemic inflammatory response syndrome (SIRS) associated with unstable fractures, and simplifies care by removing splints, traction, and other limitations placed on the patient before surgery. However, this must be balanced with the potential danger of “second hit” fracture surgery that in itself could produce SIRS and poor outcomes. This chapter attempts to briefly summarize the current state of the literature and one center’s typical care for six of the more common orthopedic trauma issues. These six issues are treatment of fractures in the patient with polytrauma (with emphasis on timing of femoral nail insertion), open fractures, compartment syndrome, acetabular fracture surgery, hip fractures (both high energy and geriatrics), and flap coverage of mangled wounds.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
D’Alleyrand JG, O’Toole RV. The evolution of damage control orthopedics: current evidence and practical applications of early appropriate care. Orthop Clin North Am. 2013;44:499–507.
Scalea TM. Optimal timing of fracture fixation: have we learned anything in the past 20 years? J Trauma. 2008;65:253–60.
Bone LB, Johnson KD, Weigelt J, Scheinberg R. Early versus delayed stabilization of femoral fractures: a prospective randomized study. J Bone Joint Surg Am. 1989;71:336–40.
Scalea TM, Boswell SA, Scott JD, Mitchell KA, Kramer ME, Pollak AN. External fixation as a bridge to intramedullary nailing for patients with multiple injuries and with femur fractures: damage control orthopedics. J Trauma. 2000;48:613–21.
Nowotarski PJ, Turen CH, Brumback RJ, Scarboro JM. Conversion of external fixation to intramedullary nailing for fractures of the shaft of the femur in multiply injured patients. J Bone Joint Surg Am. 2000;82:781–8.
Bosse MJ, MacKenzie EJ, Riemer BL, Brumback RJ, McCarthy ML, Burgess AR, Gens DR, Yasui Y. Adult respiratory distress syndrome, pneumonia, and mortality following thoracic injury and a femoral fracture treated either with intramedullary nailing with reaming or with a plate: a comparative study. J Bone Joint Surg Am. 1997;79:799–809.
O’Toole RV, O’Brien M, Scalea TM, Habashi N, Pollak AN, Turen CH. Resuscitation before stabilization of femoral fractures limits acute respiratory distress syndrome in patients with multiple traumatic injuries despite low use of damage control orthopaedics. J Trauma. 2009;67:1013–21.
Boulton CL. Damage control orthopaedics. Orthopaedic Knowledge Online. Available at: http://orthoportal.aaos.org/oko/article.aspx?article = OKO_TRA044#abstract. Accessed 18 Nov 2013.
Morshed S, Miclau III T, Bembom O, Cohen M, Knudson MM, Colford Jr JM. Delayed internal fixation of femoral shaft fracture reduces mortality among patients with multisystem trauma. J Bone Joint Surg Am. 2009;91:3–13.
Tiansheng S, Xiaobin C, Zhi L, Xiaowei W, Guang L, Liren Z. Is damage control orthopedics essential for the management of bilateral femoral fractures associated or complicated with shock? An animal study. J Trauma. 2009;67:1402–11.
Vallier HA, Wang X, Moore TA, Wilber JH, Como JJ. Timing of orthopaedic surgery in multiple trauma patients: development of a protocol for early appropriate care. J Orthop Trauma. 2013;27:543–51.
Pape HC, Grimme K, Van Griensven M, Sott AH, Giannoudis P, Morley J, Roise O, Ellingsen E, Hildebrand F, Wiese B, Krettek C, EPOFF Study Group. Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF Study Group. J Trauma. 2003;55:7–13.
Andrews PL, Shiber JR, Jaruga-Killeen E, Roy S, Sadowitz B, O’Toole RV, Gatto LA, Nieman GF, Scalea T, Habashi NM. Early application of airway pressure release ventilation may reduce mortality in high-risk trauma patents: a systemic review of observational trauma ARDS literature. J Trauma Acute Care Surg. 2013;75:635–41.
Werner CM, Pierpont Y, Pollak AN. The urgency of surgical débridement in the management of open fractures. J Am Acad Orthop Surg. 2008;16:369–75.
Pollak AN, Jones AL, Castillo RC, Bosse MJ, MacKenzie EJ, LEAP Study Group. The relationship between time to surgical débridement and incidence of infection after open high-energy lower extremity trauma. J Bone Joint Surg Am. 2010;92:7–15.
Gosselin RA, Roberts I, Gillespie WJ. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004;1, CD003764.
Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses. J Bone Joint Surg Am. 1976;58:453–8.
O’Toole RV, Whitney A, Merchant N, Hui E, Higgins J, Kim TT, Sagebien C. Variation in diagnosis of compartment syndrome by surgeons treating tibial shaft fractures. J Trauma. 2009;67:735–41.
Heppenstall RB, Scott R, Sapega A, Park YS, Chance B. A comparative study of the tolerance of skeletal muscle to ischemia: tourniquet application compared with acute compartment syndrome. J Bone Joint Surg Am. 1986;68:820–8.
Rorabeck CH, Clarke KM. The pathophysiology of the anterior tibial compartment syndrome: an experimental investigation. J Trauma. 1978;18:299–304.
Jepson PN. The classic: ischemic contracture experimental study by Paul N. Jepson, M.D. Clin Orthop Relat Res. 1975;113:3–7.
Miller HH, Welch CS. Quantitative studies on the time factor in arterial injuries. Ann Surg. 1949;130:428–38.
Sheridan GW, Matsen FA. Fasciotomy in the treatment of acute compartment syndrome. J Bone Joint Surg Am. 1976;58:112–5.
Rorabeck CH, Macnab L. Anterior tibial-compartment syndrome complicating fractures of the shaft of the tibia. J Bone Joint Surg Am. 1976;58:549–50.
Partal G, Furey A, O’Toole RV. Fasciotomy of the leg for acute compartment syndrome. In: Wiesel SW, editor. Operative techniques in orthopaedic surgery. Philadelphia, PA: Lippincott Williams & Wilkins; 2010. p. 660–70.
Matta JM. Fractures of the acetabulum: accuracy of reduction and clinical results in patients managed operatively within three weeks after the injury. J Bone Joint Surg Am. 1996;78:1632–45.
Furey AJ, Karp J, O’Toole RV. Does early fixation of posterior wall acetabular fractures lead to increased blood loss? J Orthop Trauma. 2013;27:2–5.
Gross CR, O’Toole RV, Castillo RC, Manson TT. Does early treatment of acetabular fractures lead to increased blood loss? Presented at the 27th Annual Meeting of the Orthopaedic Trauma Association. San Antonio, TX, October 2011.
Moja L, Piatti A, Pecoraro V, Ricci C, Virgili G, Salanti G, Germagnoli L, Liberati A, Banfi G. Timing matters in hip fracture surgery: patients operated within 48 hours have better outcomes: a meta-analysis and meta-regression of over 190,000 patients. PLoS One. 2012;7:e46175.
Khan SK, Kalra S, Khanna A, Thiruvengada MM, Parker MJ. Timing of surgery for hip fractures: a systematic review of 52 published studies involving 291,413 patients. Injury. 2009;40:692–7.
Damany DS, Parker MJ, Chojnowski A. Complications after intracapsular hip fractures in young adults: a meta-analysis of 18 published studies involving 564 fractures. Injury. 2005;36:131–41.
Fleisher LA, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery. Circulation. 2007;116:e418–99.
Siu CW, Sun NC, Lau TW, Yiu KH, Leung F, Tse HF. Preoperative cardiac risk assessment in geriatric patients with hip fractures: an orthopedic surgeons’ [sic] perspective. Osteoporos Int. 2010;21 Suppl 4:S587–91.
Cinello M, Nucifora G, Bertolissi M, Badano LP, Fresco C, Gonano N, Fioretti PM. American College of Cardiology/American Heart Association perioperative assessment guideline for noncardiac surgery reduces cardiologic resource utilization preserving a favourable clinical outcome. J Cardiovasc Med (Hagerstown). 2007;8:882–8.
Godina M. Early microsurgical reconstruction of complex trauma of the extremities. Plast Reconstr Surg. 1986;78:285–92.
Caudle RJ, Stern PJ. Severe open tibia fractures of the tibia. J Bone Joint Surg Am. 1987;69:801–7.
Fischer MD, Gustilo RB, Varecka TF. The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. J Bone Joint Surg Am. 1991;73:1316–22.
Cierny III G, Byrd HS, Jones RE. Primary versus delayed soft tissue coverage for severe open tibial fractures: a comparison of results. Clin Orthop Relat Res. 1983;178:54–63.
Byrd HS, Spicer TE, Cierney III G. Management of open tibial fractures. Plast Reconstr Surg. 1985;76:719–30.
Tielinen L, Lindahl JE, Tukiainen EJ. Acute unreamed intramedullary nailing and soft tissue reconstruction with muscle flaps for the treatment of severe open tibial shaft fractures. Injury. 2007;38:906–12.
Hammer R, Lidman D, Nettelblad H, Ostrup L. Team approach to tibial fracture: 37 consecutive Type III cases reviewed after 2–10 years. Acta Orthop Scand. 1992;63:471–6.
Gopal S, Majumder S, Batchelor AG, Knight SL, De Boer P, Smith RM. Fix and flap: the radical orthopaedic and plastic treatment of severe open fractures of the tibia. J Bone Joint Surg Br. 2000;82:959–66.
Yaremchuk MJ, Brumback RJ, Manson PN, Burgess AR, Poka A, Weiland AJ. Acute and definitive management of traumatic osteocutaneous defects of the lower extremity. Plast Reconstr Surg. 1987;80:1–14.
Francel TJ, Vander Kolk CA, Hoopes JE, Manson PN, Yaremchuk MJ. Microvascular soft-tissue transplantation for reconstruction of acute open tibial fractures: timing of coverage and long-term functional results. Plast Reconstr Surg. 1992;89:478–87.
Webb LX, Bosse MJ, Castillo RC, MacKenzie EJ, LEAP Study Group. Analysis of surgeon-controlled variables in the treatment of limb-threatening type-III open tibial diaphyseal fractures. J Bone Joint Surg Am. 2007;89:923–8.
D’Alleyrand JG, Manson T, Dancy L, Castillo RC, Bertumen JB, Meskey T, O’Toole RV. Is time to flap coverage of open tibial fractures an independent predictor of flap-related complications? J Orthop Trauma. 2014;28(5):288–93.
Pollak AN, McCarthy ML, Burgess AR. Short-term wound complications after application of flaps for coverage of traumatic soft-tissue defects about the tibia: The Lower Extremity Assessment Project (LEAP) Study Group. J Bone Joint Surg Am. 2000;82:1681–91.
Liporace FA, Yoon RS. Decisions and staging leading to definitive open management of pilon fractures: where have we come from and where are we now? J Orthop Trauma. 2012;26:488–98.
Stall A, Paryavi E, Gupta R, Zadnik M, Hui E, O’Toole RV. Perioperative supplemental oxygen to reduce surgical site infection after open fixation of high-risk fractures: a randomized controlled pilot trial. J Trauma Acute Care Surg. 2013;75:657–63.
Hardeski D, Gaski G, Venezia R, Nascone J, Sciadini M, O’Toole RV. Can external fixators be sterilized for surgery? A prospective cohort study in orthopaedic trauma patients. Presented at the 28th Annual Meeting of the Orthopaedic Trauma Association. Minneapolis, MN, October 2012.
Acknowledgments
This chapter is a documentation of practices and thinking that are in place at one institution during one period of time. The text has therefore been profoundly influenced by the orthopedic attending surgeons who are practicing and contributing to the application of these ideas during this time period: Christina L. Boulton, M.D.; Carol E. Copeland, M.D.; W. Andrew Eglseder, M.D.; Christopher LeBrun, M.D.; Theodore T. Manson, M.D.; Jason W. Nascone, M.D.; Gregory Osgood, M.D.; Raymond A. Pensy, M.D.; Andrew N. Pollak, M.D.; Marcus F. Sciadini, M.D.; and Clifford H. Turen, M.D.
Jean Claude D’Alleyrand, M.D., assisted with the literature search in previous projects on several of these topics. Earlene Thomas assisted with manuscript preparation. Dori Kelly, M.A., senior editor and writer at the University of Maryland School of Medicine, edited the manuscript and formatted the figure files.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
O’Toole, R.V. (2015). Timing of Fracture Fixation. In: Scalea, T. (eds) The Shock Trauma Manual of Operative Techniques. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2371-7_20
Download citation
DOI: https://doi.org/10.1007/978-1-4939-2371-7_20
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-2370-0
Online ISBN: 978-1-4939-2371-7
eBook Packages: MedicineMedicine (R0)