The chapter begins with a discussion of the major types of muscle: skeletal muscle, smooth muscle, and cardiac muscle. Then, it discusses ways to distinguish muscle weakness from other causes of weakness. The chapter focuses on four broad categories of muscle diseases: muscular dystrophy due to genetic abnormalities, channelopathies with abnormal sodium, calcium or potassium membrane ion channels, inflammatory myopathies, and secondary endocrine myopathies. The chapter ends with a complete discussion of four important types of muscle diseases: Duchenne muscular dystrophy, dermatomyositis, statin myotoxicity, and primary hyperkalemic periodic paralysis. For each disease, attention is paid to their pathophysiology, major clinical features, major laboratory findings, and principles of management and prognosis.
Pestronk A. Web site on neuromuscular diseases. www.neuro.wustl.edu/neuromuscular/index. (Outstanding, accurate, current outline information on clinical, laboratory, pathology and treatment of all muscle and peripheral nerve diseases)
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