Disorders of Muscle

  • Larry E. DavisEmail author
  • Sarah Pirio Richardson


The chapter begins with a discussion of the major types of muscle: skeletal muscle, smooth muscle, and cardiac muscle. Then, it discusses ways to distinguish muscle weakness from other causes of weakness. The chapter focuses on four broad categories of muscle diseases: muscular dystrophy due to genetic abnormalities, channelopathies with abnormal sodium, calcium or potassium membrane ion channels, inflammatory myopathies, and secondary endocrine myopathies. The chapter ends with a complete discussion of four important types of muscle diseases: Duchenne muscular dystrophy, dermatomyositis, statin myotoxicity, and primary hyperkalemic periodic paralysis. For each disease, attention is paid to their pathophysiology, major clinical features, major laboratory findings, and principles of management and prognosis.


Muscle Muscular dystrophy Dermatomyositis Statin myotoxicity Primary hyperkalemic periodic paralysis Skeletal muscle Smooth muscle Channelopathy Dystrophin Creatine kinase Inflammatory myopathy 

Supplementary material

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Recommended Reading

  1. Pestronk A. Web site on neuromuscular diseases. (Outstanding, accurate, current outline information on clinical, laboratory, pathology and treatment of all muscle and peripheral nerve diseases)
  2. Morrison LA. Dystrophinopathies. Handb Clin Neurol. 2011;101:11–39. (Good review of the muscular dystrophies—including pathophysiology and treatment recommendations)PubMedCrossRefGoogle Scholar
  3. Mammen AL. Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis. Nat Rev Neurol. 2011;7:343–54. (Good review of the autoimmune myopathies)PubMedCrossRefGoogle Scholar
  4. Kushlaf HA. Emerging toxic neuropathies and myopathies. Neurol Clin. 2011;29:679–87. (Brief summaries in an easy-to-read format of emerging toxic neuropathies and myopathies)PubMedCrossRefGoogle Scholar
  5. Ryan AM, Matthews E, Hanna MG. Skeletal-muscle channelopathies: periodic paralysis and nondystrophic myotonias. Curr Opin Neurol. 2007;20:558–63. (Recent review of channelopathies)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2015

Authors and Affiliations

  1. 1.Chief Neurology ServiceDistinguished Professor of Neurology New Mexico VA Health Care SystemAlbuquerqueUSA
  2. 2.Department of Neurology Health Sciences CenterUniversity of New MexicoAlbuquerqueUSA

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