Disorders of Pain and Headache

  • Larry E. DavisEmail author
  • Sarah Pirio Richardson


The chapter begins with a discussion of the concept of neuropathic and nociceptive pain, its physiology, and its peripheral and central nervous system pathways. The chapter next discusses common major clinical features and mechanisms of damage. The chapter ends with a discussion of tension-type headache, migraine headache, and medication-overuse headache with attention to their pathophysiology, major clinical features, major laboratory findings, and principles of management and prognosis.


Tension headache Migraine headache Medication-overuse headache Aura Allodynia Neuropathic pain Triptans 

Recommended Reading

  1. Baron R, Binder A, Wasner G. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9:807–819. (Review of current ideas about neuropathic pain)Google Scholar
  2. Woolf C, Ma Q. Nociceptors–Noxious stimulus detectors. Neuron. 2007;55:353–64. (Excellent review of normal and neuropathic nociceptive pain)Google Scholar
  3. Fumal A, Schoenen J. Tension-type headache: current research and clinical management. Lancet Neurol. 2008;7:70–82. (Nice review of tension headaches and current thoughts on pathogenesis and treatment)Google Scholar
  4. Cutrer EM. Pathophysiology of migraine. Semin Neurol. 2010;30:120–30. (Current review of what is known about migraine headaches)Google Scholar
  5. Evers S, Marziniak M. Clinical features, pathophysiology, and treatment of medication-overuse headache. Lancet Neurol. 2010;9:391–401. (Well-written review of the status of medication-overuse headache)Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2015

Authors and Affiliations

  1. 1.Chief Neurology ServiceDistinguished Professor of Neurology New Mexico VA Health Care SystemAlbuquerqueUSA
  2. 2.Department of Neurology Health Sciences CenterUniversity of New MexicoAlbuquerqueUSA

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