Cerenkov Luminescence Imaging
Cerenkov luminescence imaging (CLI) is a new modality, utilizing the blue Cerenkov light emitted from radio-isotopes decaying with particle emission. This allows for the optical imaging of clinically approved isotopes, especially those used not only for positron emission tomography (PET) imaging but also some for radiotherapy. CLI has been applied in preclinical molecular imaging and has just made the step into clinical imaging, where one of CLI’s most promising applications is intraoperative imaging, bridging the gap between the few available targeted fluorescent agents and the multitude of clinically used radiotracers. Using CLI for intraoperative imaging would provide a much larger and readily available list of agents than currently available for fluorescence imaging and allows for preoperative PET and intraoperative imaging with the same agent. This chapter discusses the basics of CLI, its promises, and challenges with respect to its application in intraoperative imaging.
KeywordsCerenkov Cerenkov luminescence imaging CLI Intraoperative imaging Optical imaging PET Multimodality imaging
This work and JG was partially supported by funding from the NIH NIBIB and NCI (NIH R01EB014944 and R01CA183953)
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