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Oxidative Stress in Unexplained Female Infertility

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Unexplained Infertility

Abstract

Oxidative stress is an imbalance between free radicals and antioxidants. It has been demonstrated that oxidative stress may play an important role in subfertility. Studies have shown a close relationship between oxidative stress and polycystic ovarian syndrome and endometriosis. However, the relationship between oxidative stress and unexplained female infertility has not been studied in detail. This chapter reviews the possible associations between oxidative stress and the underlying mechanisms that contribute to unexplained infertility. The correlations between oxidative stress and oocytes, folliculogenesis, ovulation, fertilization, implantation, oocyte and embryo quality are also discussed. Articles were identified through a search of the Pubmed database. It has been found that oxidative stress plays an important role in etiologic factors that may contribute to unexplained infertility such as defective endometrial receptivity, impaired oocyte quality, premature ovarian failure, minimal and mild endometriosis, tubal disease, pelvic adhesions, and immunological and endocrinological abnormalities. Moreover, it has been demonstrated that reactive oxygen species can also negatively affect ovulation, fertilization, implantation, embryo quality, and pregnancy rates. However, the use of antioxidant therapy in that group remains unclear. Further studies are needed to show the effectiveness of antioxidants in that group.

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Verit, F. (2015). Oxidative Stress in Unexplained Female Infertility. In: Schattman, G., Esteves, S., Agarwal, A. (eds) Unexplained Infertility. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2140-9_14

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