Understanding and Treating Cytopenia Through Mathematical Modeling

  • Jinzhi Lei
  • Michael C. Mackey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 844)


Here, we briefly review how the study of dynamic hematological diseases with mathematical modeling tools has led to a better understanding of the origin of some types of neutropenia and thrombocytopenia and to improved treatment strategies. In addition, we have briefly discussed how these models suggest improved ways to minimize and/or treat cytopenia induced by chemotherapy.


Anemia Chemotherapy Granulocyte colony-stimulating factor Neutropenia Thrombocytopenia Thrombopoietin 



This work was supported by the Natural Sciences and Engineering Research Council (NSERC, Canada) and the Mathematics of Information Technology and Complex Systems (MITACS, Canada), and carried out in Beijing and Montreal.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Zhou Pei-Yuan Center for Applied MathematicsTsinghua UniversityBeijingChina
  2. 2.Department of Physiology and CAMBAMMonteralCanada

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