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Systems Hematology: An Introduction

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A Systems Biology Approach to Blood

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 844))

Abstract

Hematologists have traditionally studied blood and its components by simplifying it into its components and functions. A variety of new techniques have generated large and complex datasets. Coupled to an appreciation of blood as a dynamic system, a new approach in systems hematology is needed. Systems hematology embraces the multi-scale complexity with a combination of mathematical, engineering, and computational tools for constructing and validating models of biological phenomena. The validity of mathematical modeling in hematopoiesis was established early by the pioneering work of Till and McCulloch. This volume seeks to introduce to the various scientists and physicians to the multi-faceted field of hematology by highlighting recent works in systems biology. Deterministic, stochastic, statistical, and network-based models have been used to better understand a range of topics in hematopoiesis, including blood cell production, the periodicity of cyclical neutropenia, stem cell production in response to cytokine administration, and the emergence of drug resistance. Future advances require technological improvements in computing power, imaging, and proteomics as well as greater collaboration between experimentalists and modelers. Altogether, systems hematology will improve our understanding of normal and abnormal hematopoiesis, better define stem cells and their daughter cells, and potentially lead to more effective therapies.

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Author information

Authors and Affiliations

  1. Department of Pediatrics and Cell & Molecular Biology, Northwestern University Feinberg School of Medicine, Lurie 5-107, 303 E. Superior St., 60611, Chicago, IL, USA

    Seth Joel Corey MD, MPH

  2. Department of Statistics and Bioengineering, Rice University, 2102 Duncan Hall, 6100 Main St., 77005, Houston, TX, USA

    Marek Kimmel PhD

  3. Technological Institute, Rm E136, 2145 Sheridan Rd., 60208-3120, Evanston, IL, USA

    Joshua N. Leonard PhD

Authors
  1. Seth Joel Corey MD, MPH
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  2. Marek Kimmel PhD
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  3. Joshua N. Leonard PhD
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Corresponding author

Correspondence to Seth Joel Corey MD, MPH .

Editor information

Editors and Affiliations

  1. Departments of Pediatrics and Cell & Molecular Biology, Northwestern University Feinberg School of Medicine and Lurie Children’s Hospital of Chicago, Chicago, Illinois, USA

    Seth Joel Corey

  2. Department of Statistics, Rice University, Houston, Texas, USA

    Marek Kimmel

  3. Northwestern University Comprehensive Cancer Center, Evanston, Illinois, USA

    Joshua N. Leonard

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Corey, S., Kimmel, M., Leonard, J. (2014). Systems Hematology: An Introduction. In: Corey, S., Kimmel, M., Leonard, J. (eds) A Systems Biology Approach to Blood. Advances in Experimental Medicine and Biology, vol 844. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2095-2_1

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