TSH-Secreting Pituitary Adenoma

  • Abdulrahman Alkabbani
  • Roberto Salvatori
  • David S. Cooper

Abstract

TSH-producing pituitary adenoma is a rare cause of thyrotoxicosis, and the rarest of all types of secretory pituitary adenomas. We present a case of a 55-year-old man who, after 6 years of therapy for presumed hypothyroidism, was diagnosed with a TSH-producing pituitary adenoma. He was lost to follow-up after that, to present again with thyrotoxicosis and atrial flutter 10 years later. We review the presentation, evaluation, treatment, and differential diagnosis of TSH-producing adenomas.

Keywords

Thyrotoxicosis TSH-secreting adenoma Struma ovarii Exogenous thyrotoxicosis Thyroid gland TSH Free T4 

References

  1. 1.
    Beck-Peccoz P, Persani L, Mannavola D, Campi I. Pituitary tumours: TSH-secreting adenomas. Best Pract Res Clin Endocrinol Metab. 2009;23:597–606.CrossRefPubMedGoogle Scholar
  2. 2.
    Rouach V, Greenman Y. Thyrotropin-secreting pituitary tumors. In: Melmed S, editor. The pituitary. Burlington: Academic Press; 2011. p. 619–36.CrossRefGoogle Scholar
  3. 3.
    George JT, Thow JC, Matthews B, Pye MP, Jayagopal V. Atrial fibrillation associated with a thyroid stimulating hormone-secreting adenoma of the pituitary gland leading to a presentation of acute cardiac decompensation: a case report. J Med Case Rep. 2008;2:67.PubMedCentralCrossRefPubMedGoogle Scholar
  4. 4.
    Brucker-Davis F, Oldfield EH, Skarulis MC, Doppman JL, Weintraub BD. Thyrotropin-secreting pituitary tumors: diagnostic criteria, thyroid hormone sensitivity, and treatment outcome in 25 patients followed at the national institutes of health. J Clin Endocrinol Metab. 1999;84:476–86.CrossRefPubMedGoogle Scholar
  5. 5.
    Socin HV, Chanson P, Delemer B, et al. The changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients. Eur J Endocrinol. 2003;148:433–42.CrossRefPubMedGoogle Scholar
  6. 6.
    Beck-Peccoz P, Brucker-Davis F, Persani L, Smallridge RC, Weintraub BD. Thyrotropin-secreting pituitary tumors. Endocr Rev. 1996;17:610–38.PubMedGoogle Scholar
  7. 7.
    Losa M, Mortini P, Minelli R, Giovanelli M. Coexistence of TSH-secreting pituitary adenoma and autoimmune hypothyroidism. J Endocrinol Invest. 2006;29:555–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Colao A, Pivonello R, Di Somma C, Savastano S, Grasso LF, Lombardi G. Medical therapy of pituitary adenomas: effects on tumor shrinkage. Rev Endocr Metab Disord. 2009;10:111–23.CrossRefPubMedGoogle Scholar
  9. 9.
    Dumitrescu AM, Refetoff S. The syndromes of reduced sensitivity to thyroid hormone. Biochim Biophys Acta. 2013;1830(7):3987–4003.PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Abdulrahman Alkabbani
    • 1
  • Roberto Salvatori
    • 1
  • David S. Cooper
    • 2
  1. 1.Division of Endocrinology and MetabolismJohns Hopkins HospitalBaltimoreUSA
  2. 2.Division of Endocrinology and MetabolismThe Johns Hopkins University School of MedicineBaltimoreUSA

Personalised recommendations