Abstract
Testicular function is under the control of gonadotropin-releasing hormone (GnRH) produced by neurons in the anterior hypothalamus. GnRH stimulates the synthesis and secretion of the pituitary gonadotropic hormones, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), which are composed of a common alpha subunit, shared with TSH and hCG, and a specific β-subunit (LH-β or FSH-β). LH and FSH are released into the circulation in pulses and activate G-protein-coupled receptors on Leydig and Sertoli cells, respectively, in order to stimulate testosterone production and spermatogenesis.
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Winters, S.J., Krishnasamy, S. (2015). Introduction. In: Davies, T. (eds) A Case-Based Guide to Clinical Endocrinology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2059-4_33
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DOI: https://doi.org/10.1007/978-1-4939-2059-4_33
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