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Urine Cytology

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Genitourinary Pathology

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Abstract

Urine cytology is a minimally invasive technique for the diagnosis and surveillance of urothelial carcinoma of the bladder and ureter. While the test has high specificity, its low sensitivity may be augmented through the use of ancillary studies. The most commonly used is fluorescence in situ hybridization (FISH) to detect for aneuploidy cells in urine samples.

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References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29.

    Article  PubMed  Google Scholar 

  2. Smith ZL, Christodouleas JP, Keefe SM, Malkowicz SB, Guzzo TJ. Bladder preservation in the treatment of muscle-invasive bladder cancer (MIBC): a review of the literature and a practical approach to therapy. BJU Int. 2013;112(1):13–25. Epub 2013/01/30.

    Article  PubMed  Google Scholar 

  3. Grossman HB, Natale RB, Tangen CM, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med. 2003;349(9):859–66.

    Article  CAS  PubMed  Google Scholar 

  4. Bastacky S, Ibrahim S, Wilczynski SP, Murphy WM. The accuracy of urinary cytology in daily practice. Cancer Cytopathol. 1999;87(3):118–28.

    Article  CAS  Google Scholar 

  5. Cohen RA, Brown RS. Microscopic hematuria. N Engl J Med. 2003;348(23):2330–8.

    Article  PubMed  Google Scholar 

  6. Khadra MH, Pickard RS, Charlton M, Powell PH, Neal DE. A prospective analysis of 1,930 patients with hematuria to evaluate current diagnostic practice. J Urol. 2000;163(2):524–7.

    Article  CAS  PubMed  Google Scholar 

  7. Blick CGT, Nazir SA, Mallett S, et al. Evaluation of diagnostic strategies for bladder cancer using computed tomography (CT) urography, flexible cystoscopy and voided urine cytology: results for 778 patients from a hospital haematuria clinic. BJU Int. 2012;110(1):84–94.

    Article  PubMed  Google Scholar 

  8. Grossfeld GD, Litwin MS, Wolf JS, et al. Evaluation of asymptomatic microscopic hematuria in adults: the American urological association best practice policy—part II: patient evaluation, cytology, voided markers, imaging, cystoscopy, nephrology evaluation, and follow-up. Urology. 2001;57(4):604–10.

    Article  CAS  PubMed  Google Scholar 

  9. Brien JC, Shariat SF, Herman MP, et al. Preoperative hydronephrosis, ureteroscopic biopsy grade and urinary cytology can improve prediction of advanced upper tract urothelial carcinoma. J Urol. 2010;184(1):69–73.

    Article  PubMed  Google Scholar 

  10. Raab SS, Grzybicki DM, Vrbin CM, Geisinger KR. Urine cytology discrepancies—frequency, causes, and outcomes. Am J Clin Pathol. 2007;127(6):946–53.

    Article  PubMed  Google Scholar 

  11. Kapur U, Venkataraman G, Wojcik EM. Diagnostic significance of ‘atypia’ in instrumented versus voided urine specimens. Cancer Cytopathol. 2008;114(4):270–4.

    Article  Google Scholar 

  12. Huguet-Perez J, Palou J, Millan-Rodriguez F, Salvador-Bayarri J, Villavicencio-Mavrich H, Vicente-Rodriguez J. Upper tract transitional cell carcinoma following cystectomy for bladder cancer. Eur Urol. 2001;40(3):318–23.

    Article  CAS  PubMed  Google Scholar 

  13. Yoshimine S, Kikuchi E, Matsumoto K, et al. The clinical significance of urine cytology after a radical cystectomy for urothelial cancer. Int J Urol. 2010;17(6):527–32.

    Article  PubMed  Google Scholar 

  14. Mody DR. Defining adequacy in nongynecologic specimens. CAP Today. 2003;17:68–70.

    Google Scholar 

  15. Jackson J, Barkan GA, Kapur U, Wojcik EM. Cytologic and cystoscopic predictors of recurrence and progression in patients with low-grade urothelial carcinoma. Cancer Cytopathol. 2013;121(7):398–402.

    Article  PubMed  Google Scholar 

  16. Rosa M. Clinical significance of dysplastic squamous cells in exfoliative urine cytology. Diagn Cytopathol. 2010;38(6):468–9.

    PubMed  Google Scholar 

  17. Wheat LJ, Kohler RB, Tewari RP. Diagnosis of disseminated histoplasmosis by detection of histoplasma-capsulatum antigen in serum and urine specimens. N Engl J Med. 1986;314(2):83–8.

    Article  CAS  PubMed  Google Scholar 

  18. Aggarwal S, Arora VK, Gupta S, Singh N, Bhatia A. Koilocytosis: correlations with high-risk HPV and its comparison on tissue sections and cytology, urothelial carcinoma. Diagn Cytopathol. 2009;37(3):174–7.

    Article  PubMed  Google Scholar 

  19. Jong EE, Mulder JW, van Gorp ECM, et al. The prevalence of human papillomavirus (HPV) infection in paired urine and cervical smear samples of HIV-infected women. J Clin Virol. 2008;41(2):111–5.

    Article  PubMed  Google Scholar 

  20. LeBlanc RE, Maleki Z. Herpes simplex viral cytopathic effect in urine cytology. Diagn Cytopathol. 2013;41(1):61–2.

    Article  PubMed  Google Scholar 

  21. Singh HK, Bubendorf L, Mihatsch MJ, Drachenberg CB, Nickeleit V. Urine cytology findings of polyomavirus infections. In: Ahsan N, editor. Polyomaviruses and human diseases. New York: Springer; 2006. pp. 201–12.

    Chapter  Google Scholar 

  22. Drachenberg CB, Beskow CO, Cangro CB, et al. Human polyoma virus in renal allograft biopsies: morphological findings and correlation with urine cytology. Hum Pathol. 1999;30(8):970–7.

    Article  CAS  PubMed  Google Scholar 

  23. Wang Z, Portier BP, Hu B, et al. Diagnosis of BK viral nephropathy in the renal allograft biopsy role of fluorescence in situ hybridization. J Mol Diagn. 2012;14(5):494–500.

    Article  PubMed  Google Scholar 

  24. Li RM, Mannon RB, Kleiner D, et al. BK virus and SV40 co-infection in polyomavirus nephropathy. Transplantation. 2002;74(11):1497–504.

    Article  PubMed  Google Scholar 

  25. Randhawa P, Vats A, Shapiro R. Monitoring for polyomavirus BK and JC in urine: comparison of quantitative polymerase chain reaction with urine cytology. Transplantation. 2005;79(8):984–6.

    Article  CAS  PubMed  Google Scholar 

  26. Egli A, Infanti L, Dumoulin A, et al. Prevalence of Polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis. 2009;199(6):837–46.

    Article  CAS  PubMed  Google Scholar 

  27. Lotan Y, Roehrborn CG. Sensitivity and specificity of commonly available bladder tumor markers versus cytology: results of a comprehensive literature review and meta-analyses. Urology. 2003;61(1):109–18.

    Article  PubMed  Google Scholar 

  28. Koss LG, Deitch D, Ramanathan R, Sherman AB. Diagnostic-value of cytology of voided urine. Acta Cytol. 1985;29(5):810–6.

    CAS  PubMed  Google Scholar 

  29. Ubago JM, Mehta V, Wojcik EM, Barkan GA. Evaluation of atypical urine cytology progression to malignancy. Cancer Cytopathol. 2013;121(7):387–91.

    Article  Google Scholar 

  30. Williams SK, Denton KJ, Minervini A, et al. Correlation of upper-tract cytology, retrograde pyelography, ureteroscopic appearance, and ureteroscopic biopsy with histologic examination of upper-tract transitional cell carcinoma. J Endourol. 2008;22(1):71–6.

    Article  PubMed  Google Scholar 

  31. Raj GV, Bochner BH, Serio AM, et al. Natural history of positive urinary cytology after radical cystectomy. J Urol. 2006;176(5):2000–5.

    Article  PubMed  Google Scholar 

  32. Whisnant RE, Bastacky SI, Ohori NP. Cytologic diagnosis of low-grade papillary urothelial neoplasms (low malignant potential and low-grade carcinoma) in the context of the 1998 WHO/ISUP classification. Diagn Cytopathol. 2003;28(4):186–90.

    Article  PubMed  Google Scholar 

  33. Dubal SB, Pathuthara S, Ajit D, Menon S, Kane SV. Case report of renal cell carcinoma diagnosed in voided urine confirmed by CD10 immunocytochemistry. Acta Cytol. 2011;55(4):372–6.

    Article  PubMed  Google Scholar 

  34. Sathiyamoorthy S, Ali SZ. Urinary cytology of prostatic duct adenocarcinoma—a clinicopathologic analysis. Acta Cytol. 2013;57(2):184–8.

    Article  PubMed  Google Scholar 

  35. Tyler KL, Selvaggi SM. Morphologic features of prostatic adenocarcinoma on ThinPrep(R) urinary cytology. Diagn Cytopathol. 2011;39(2):101–4.

    Article  PubMed  Google Scholar 

  36. Dalquen P, Kleiber B, Grilli B, Herzog M, Bubendorf L, Oberholzer M. DNA image cytometry and fluorescence in situ hybridization for noninvasive detection of urothelial tumors in voided urine. Cancer Cytopathol. 2002;96(6):374–9.

    Article  Google Scholar 

  37. Daniely M, Rona R, Kaplan T, et al. Combined analysis of morphology and fluorescence in situ hybridization significantly increases accuracy of bladder cancer detection in voided urine samples. Urology. 2005;66(6):1354–9.

    Article  PubMed  Google Scholar 

  38. Keay S, Warren JW, Zhang CO, Tu LM, Gordon DA, Whitmore KE. Antiproliferative activity is present in bladder but not renal pelvic urine from interstitial cystitis patients. J Urol. 1999;162(4):1487–9.

    Article  CAS  PubMed  Google Scholar 

  39. Wu CF, Pang ST, Shee JJ, et al. Identification of genetic alterations in upper urinary tract urothelial carcinoma in end-stage renal disease patients. Genes Chromosomes Cancer. 2010;49(10):928–34.

    Article  CAS  PubMed  Google Scholar 

  40. Mian C, Pycha A, Wiener H, Haitel A, Lodde M, Marberger M. Immunocyt: a new tool for detecting transitional cell cancer of the urinary tract. J Urol. 1999;161(5):1486–9.

    Article  CAS  PubMed  Google Scholar 

  41. Schlake A, Crispen PL, Cap AP, Atkinson T, Davenport D, Preston DM. NMP-22, urinary cytology, and cystoscopy: a 1 year comparison study. Can J Urol. 2012;19(4):6345–50.

    PubMed  Google Scholar 

  42. Mansoor I, Calam RR, Al-Khafaji B. Role of urinary NMP-22 combined with urine cytology in follow-up surveillance of recurring superficial bladder urothelial carcinoma. Anal Quant Cytol Histol. 2008;30(1): 25–32.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Cleveland Clinic, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland, OH, USA

    Assistant Professor Jordan P. Reynolds MD

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  1. Assistant Professor Jordan P. Reynolds MD
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Correspondence to Jordan P. Reynolds MD .

Editor information

Editors and Affiliations

  1. Department of Pathology, The Cleveland Clinic, Cleveland, Ohio, USA

    Cristina Magi-Galluzzi

  2. Department of Pathology, The Cleveland Clinic, Cleveland, Ohio, USA

    Christopher G. Przybycin

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Reynolds, J. (2015). Urine Cytology. In: Magi-Galluzzi, C., Przybycin, C. (eds) Genitourinary Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2044-0_21

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  • DOI: https://doi.org/10.1007/978-1-4939-2044-0_21

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2043-3

  • Online ISBN: 978-1-4939-2044-0

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