Anti-HER2/neu Therapy in DCIS

  • Amelia Tower
  • Ruta D. Rao
  • Kalliopi P. Siziopikou
  • Melody A. Cobleigh
  • Thomas B. Julian


Ductal carcinoma in situ (DCIS) is a heterogeneous form of preinvasive breast cancer, with subtypes that are comparable to those of invasive disease. Targeted molecular therapies have improved outcomes for patients with invasive breast cancer, and we have parallel opportunities for advances in personalized treatment of DCIS. Early work has demonstrated synergy between human epidermal growth factor receptor (HER)2-targeted therapy and radiotherapy. Anti-HER2 therapy may also induce an immune response. This chapter addresses the history of research regarding HER2 expression in DCIS as well as ongoing clinical trials that address whether HER2-targeted therapy will improve patient outcomes in DCIS.


Ductal carcinoma in situ HER2/neu Trastuzumab Radiotherapy 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Amelia Tower
    • 1
  • Ruta D. Rao
    • 3
  • Kalliopi P. Siziopikou
    • 2
    • 4
  • Melody A. Cobleigh
    • 3
  • Thomas B. Julian
    • 1
    • 5
    • 6
    • 7
  1. 1.Division of Breast Surgical OncologyAllegheny General HospitalPittsburghUSA
  2. 2.Robert H. Lurie Comprehensive Cancer CenterChicagoUSA
  3. 3.Section of Medical Oncology, Department of Internal MedicineRush University Medical CenterChicagoUSA
  4. 4.Breast Pathology Section, Department of PathologyNorthwestern University Feinberg School of MedicineChicagoUSA
  5. 5.WPAHS Breast Surgical OncologyAllegheny Health NetworkPittsburghUSA
  6. 6.Temple University School of MedicinePhiladelphiaUSA
  7. 7.Medical AffairsNational Surgical Adjuvant Breast and Bowel Project (NSABP)PittsburghUSA

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