Abstract
Carcinosarcoma of the skin (CS) is an extremely rare biphasic neoplasm composed of intimately admixed malignant epithelial and mesenchymal elements. These tumors occur more frequently in the internal organs such as the female and male genital tracts, gastrointestinal tract, lungs, breast, upper and lower urinary system, oronasopharynx, larynx, thyroid, and thymus. Occurrence in the skin is extremely rare. Only about 40 cases have been reported in literature, mostly as single cases or small series. Different theories have been proposed to explain the pathogenesis of CS: a collision tumor of two unrelated tumors, a combination of two divergent cell lines from a single stem cell, and a metaplastic transformation of part of the carcinoma into a sarcoma.
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Bibliography
Bigby SM, Charlton A, Miller MV, Zwi LJ, Oliver GF. Biphasic sarcomatoid basal cell carcinoma (carcinosarcoma): four cases with immunohistochemistry and review of the literature. J Cutan Pathol. 2005;32:141–7.
Buonaccorsi JN, Plaza JA. Role of CD10, wide-spectrum keratin, p63, and podoplanin in the distinction of epithelioid and spindle cell tumors of the skin: an immunohistochemical study of 81 cases. Am J Dermatopathol. 2012;34:404–11.
Kiuru M, McDermott G, Coit DC, Berger MF, Busam KJ. Basal cell carcinosarcoma with PTCH1 mutations in both epithelial and sarcomatoid primary tumor components and in the sarcomatoid metastasis. Am J Surg Pathol. 2014;38:138–42.
Patel NK, McKee PH, Smith NP, Fletcher CD. Primary metaplastic carcinoma (carcinosarcoma) of the skin. A clinicopathologic study of four cases and review of the literature. Am J Dermatopathol. 1997;19:363–72.
Romanelli P, Miteva M, Schwartzfarb E, Ricotti C, Sullivan T, Abenoza P, Nadji M. P63 is a helpful tool in the diagnosis of a primary cutaneous carcinosarcoma. J Cutan Pathol. 2009;36:280–2.
Rouas L, Amrani M, Regragui A, Gamra L, Bellabas MA. Carcinosarcoma of the skin. Ann Dermatol Venereol. 2006;133:362–5.
Tran TA, Muller S, Chaudahri PJ, Carlson JA. Cutaneous carcinosarcoma: adnexal vs. epidermal types define high- and low-risk tumors. Results of a meta-analysis. J Cutan Pathol. 2005;32:2–11.
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Caputo, V., Rongioletti, F. (2015). Carcinosarcoma. In: Rare Malignant Skin Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2023-5_6
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DOI: https://doi.org/10.1007/978-1-4939-2023-5_6
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