Abstract
Clear cell squamous cell carcinoma (clear cell SCC) was first described by Kuo in 1980 as a rare variant of squamous cell carcinoma (SCC). It appears predominantly on sun-exposed sites in elderly. The neoplasm is formed by sheets or islands of clear cells with empty-appearing or “bubbled” cytoplasm. Signet-ring cell squamous cell carcinoma (signet-ring cell SCC) is a very rare histopathological variant of SCC with only a few cases reported. It can be exceedingly difficult to differentiate this neoplasm from both primary cutaneous and secondary adenocarcinomas.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Bibliography
Cramer SF, Heggeness LM. Signet-ring squamous cell carcinoma. Am J Clin Pathol. 1989;91:488–91.
Dalton SR, LeBoit PE. Squamous cell carcinoma with clear cells: how often is there evidence of trichilemmal differentiation? Am J Dermatopathol. 2008;30:333–9.
El Demellawy D, Onuma K, Alowami S. Signet ring squamous cell carcinoma- the forgotten variant: case report and review of the literature. J Cutan Pathol. 2011;38:306–8.
Headington JT. Trichilemmal carcinoma. J Cutan Pathol. 1992:83–4.
Kuo T. Clear cell carcinoma of the skin: a variant of the squamous cell carcinoma that simulates sebaceous carcinoma. Am J Surg Pathol. 1980:573–83.
Lee JY, Tang CK, Leung YS. Clear cell carcinoma of the skin: a trichilemmal carcinoma? J Cutan Pathol. 1989;16:31–9.
Misago N, Ackerman AB. New quandary: trichilemmal carcinoma? Dermatopathol Pract Concept. 1999:463–73.
Yanofsky VR, Mercer SE, Phelps RG. Histopathological variants of cutaneous squamous cell carcinoma: a review. J Skin Cancer. 2011;2011, 210813. doi: 10.1155/2011/210813. Epub 2010 Dec 29.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Margaritescu, I., Chirita, A.D. (2015). Clear Cell and Signet-Ring Cell Squamous Cell Carcinoma. In: Rare Malignant Skin Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2023-5_2
Download citation
DOI: https://doi.org/10.1007/978-1-4939-2023-5_2
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-2022-8
Online ISBN: 978-1-4939-2023-5
eBook Packages: MedicineMedicine (R0)