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Nutrition in Pregnancy and Lactation

  • Bonny L. SpeckerEmail author
Chapter
Part of the Nutrition and Health book series (NH)

Abstract

Pregnancy and lactation are periods of significant change in calcium and bone metabolism for the mother. Physiological changes that occur insure that there is an adequate calcium supply for fetal growth, milk production, and maternal bone recovery. During pregnancy, low maternal calcium intake is associated with low neonatal BMC and maternal vitamin D deficiency influences fetal bone development and neonatal calcium homeostasis. Whether maternal vitamin D status during pregnancy influences infant growth trajectories or bone accrual later in childhood is not known. Due to potential adverse effects of high maternal vitamin D concentrations on the offspring, it is important that all current and future supplementation trials investigate the influence of not just low serum 25-OHD concentrations, but also high concentrations, on these outcomes.

Keywords

Fetal programming Weaning Bone density Bone accrual Vitamin D deficiency 

References

  1. 1.
    Widdowson EM, Southgate DAT, Hey E. Fetal growth and body composition. In: Landblad BS, editor. Perinatal nutrition. New York, NY: Academic; 1988.Google Scholar
  2. 2.
    Forbes GB. Letter: calcium accumulation by the human fetus. Pediatrics. 1976;57:976–7.PubMedGoogle Scholar
  3. 3.
    Laskey MA, Prentice A, Hanratty LA, Jarjou LMA, Dibba B, Beavan SR, et al. Bone changes after 3 mo of lactation: influence of calcium intake, breast-milk output, and vitamin D-receptor genotype. Am J Clin Nutr. 1998;67:685–92.PubMedGoogle Scholar
  4. 4.
    Kent GN, Price RI, Gutteridge DH, Rosman KJ, Smith M, Allen JR, et al. The efficiency of intestinal calcium absorption is increased in late pregnancy but not in established lactation. Calcif Tissue Int. 1991;48:293–5.PubMedGoogle Scholar
  5. 5.
    Cross NA, Hillman LS, Allen SH, Krause GF, Vieira NE. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr. 1995;61:514–23.PubMedGoogle Scholar
  6. 6.
    Ritchie LD, Fung EB, Halloran BP, Turnlund JR, VanLoan MD, Cann CE, et al. A longitudinal study of calcium homeostasis during human pregnancy and lactation and after resumption of menses. Am J Clin Nutr. 1998;67:693–701.PubMedGoogle Scholar
  7. 7.
    Specker BL, Tsang RC, Ho ML, Miller D. Effect of vegetarian diet on serum 1,25-dihydroxyvitamin D concentrations during lactation. Obstet Gynecol. 1987;70:870–4.PubMedGoogle Scholar
  8. 8.
    O’Brien KO, Donangelo CM, Ritchie LD, Gildengorin G, Abrams S, King JC. Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of calcium deposition during pregnancy and the early postpartum period. Am J Clin Nutr. 2012;96:64–72.PubMedCentralPubMedGoogle Scholar
  9. 9.
    Bezerra FF, Laboissiere FP, King JC, Donangelo CM. Pregnancy and lactation affect markers of calcium and bone metabolism differently in adolescent and adult women with low calcium intakes. J Nutr. 2002;132:2183–7.PubMedGoogle Scholar
  10. 10.
    Seki K, Makimura N, Mitsui C, Hirata J, Nagata I. Calcium-regulating hormones and osteocalcin levels during pregnancy: A longitudinal study. Am J Obstet Gynecol. 1991;164:1248–52.PubMedGoogle Scholar
  11. 11.
    Heaney RP, Skillman TG. Calcium metabolism in normal pregnancy. J Clin Endocrinol. 1971;33:661–70.Google Scholar
  12. 12.
    Kovacs CS. The role of vitamin D in pregnancy and lactation: Insights from animal models and clinical studies. Annu Rev Nutr. 2012;32:97–123.PubMedGoogle Scholar
  13. 13.
    Naylor KE, Iqbal P, Fledelius C, Fraser RB, Eastell R. The effect of pregnancy on bone density and bone turnover. J Bone Miner Res. 2000;15:129–37.PubMedGoogle Scholar
  14. 14.
    O’Brien KO, Donangelo CM, Zapata CL, Abrams SA, Spencer EM, King JC. Bone calcium turnover during pregnancy and lactation in women with low calcium diets is associated with calcium intake and circulating insulin-like growth factor 1 concentrations. Am J Clin Nutr. 2006;83(2):317–23. Epub 2006/02/14.PubMedGoogle Scholar
  15. 15.
    Kent GN, Price RI, Gutteridge DH, Allen JR, Rosman KJ, Smith M, et al. Effect of pregnancy and lactation on maternal bone mass and calcium metabolism. Osteoporos Int. 1993;1:S44–7.Google Scholar
  16. 16.
    Martin TJ, Gillespie MT. Receptor activator of nuclear factor kappa B ligand (RANKL): another link between breast and bone. Trends Endocrinol Metab. 2001;12:2–4.PubMedGoogle Scholar
  17. 17.
    Uemura H, Yasui T, Kiyokawa M, Kuwahara A, Ikawa H, Matsuzaki T, et al. Serum osteoprotegerin/osteoclastogenesis-inhibitory factor during pregnancy and lactation and the relationship with calcium-regulating hormones and bone turnover markers. J Endocrinol. 2002;174:353–9.PubMedGoogle Scholar
  18. 18.
    Naylor KE, Rogers A, Fraser RB, Hall V, Eastell R, Blumsohn A. Serum osteoprotegrin as a determinant of bone metabolism in a longitudinal study of human pregnancy and lactation. J Clin Endocrinol Metab. 2003;88:5361–5.PubMedGoogle Scholar
  19. 19.
    Ensom MHH, Liu PY, Stephenson MD. Effect of pregnancy on bone mineral density in healthy women. Obstet Gynecol Surv. 2002;57:99–111.PubMedGoogle Scholar
  20. 20.
    Tothill P, Avenell A. Errors in dual-energy x-ray absorptiometry of the lumbar spine owing to fat distribution and soft tissue thickness during weight change. Br J Radiol. 1994;67:71–5.PubMedGoogle Scholar
  21. 21.
    Sowers MF, Scholl T, Harris L, Jannausch M. Bone loss in adolescent and adult pregnant women. Obstet Gynecol. 2000;96:189–93.PubMedGoogle Scholar
  22. 22.
    Specker BL, Vieira NE, O’Brien KO, Ho ML, Heubi JE, Abrams SA, et al. Calcium kinetics in lactating women with low and high calcium intakes. Am J Clin Nutr. 1994;59:593–9.PubMedGoogle Scholar
  23. 23.
    Kalkwarf HJ, Specker BL, Heubi JE, Vieira NE, Yergey AL. Intestinal calcium absorption of women during lactation and after weaning. Am J Clin Nutr. 1996;63:526–31.PubMedGoogle Scholar
  24. 24.
    Moser-Veillon PG, Mangels AR, Vieira NE, Yergy AL, Patterson KY, Hill AD, et al. Calcium fractional absorption and metabolism assessed using stable isotopes differ between postpartum and never pregnant women. J Nutr. 2001;131:2295–9.PubMedGoogle Scholar
  25. 25.
    Kent GN, Price RI, Gutteridge D, Smith M, Allen J, Bhagat C, et al. Human lactation: forearm trabecular bone loss, increased bone turnover, and renal conservation of calcium and inorganic phosphate with recovery of bone mass following weaning. J Bone Miner Res. 1990;5:361–9.PubMedGoogle Scholar
  26. 26.
    Kalkwarf HJ, Specker BL, Ho M. Effects of calcium supplementation on calcium homeostasis and bone turnover in lactating women. J Clin Endocrinol Metab. 1999;84:464–70.PubMedGoogle Scholar
  27. 27.
    Kumar R, Cohen WR, Silva P, Epstein FH. Elevated 1,25-dihydroxyvitamin D plasma levels in normal human pregnancy and lactation. J Clin Investig. 1979;63:342–4.PubMedCentralPubMedGoogle Scholar
  28. 28.
    Hillman L, Sateesha S, Haussler M, Wiest W, Slatopolsky E, Haddad J. Control of mineral homeostasis durig lactation: Interrelationships of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, 1,25-dihydroxyvitamin D, parathyroid hormone, calcitonin, prolactin, and estradiol. Am J Obstet Gynecol. 1981;139:471–6.PubMedGoogle Scholar
  29. 29.
    Affinito P, Tommaselli GA, DiCarlo C, Guida F, Nappi C. Changes in bone mineral density and calcium metabolism in breast-feeding women: A one year follow-up study. J Clin Endocrinol Metab. 1996;81:2314–8.PubMedGoogle Scholar
  30. 30.
    Krebs NF, Reidinger CJ, Robertson AD, Brenner M. Bone mineral density changes during lactation: maternal, dietary, and biochemical correlates. Am J Clin Nutr. 1997;65:1738–46.PubMedGoogle Scholar
  31. 31.
    Prentice A, Jarjou LMA, Stirling DM, Buffenstein R, Fairweather-Tait S. Biochemical markers of calcium and bone metabolism during 18 months of lactation in Gambian women accustomed to a low calcium intake and in those consuming a calcium supplement. J Clin Endocrinol Metab. 1998;83:1059–66.PubMedGoogle Scholar
  32. 32.
    Sowers MF, Eyre D, Hollis BW, Randolph JF, Shapiro B, Jannausch ML, et al. Biochemical markers of bone turnover in lactating and nonlactating postpartum women. J Clin Endocrinol Metab. 1995;80:2210–6.PubMedGoogle Scholar
  33. 33.
    Sowers MF, Hollis BW, Shapiro B, et al. Elevated parathyroid hormone-related peptide associated with lactation and bone density loss. JAMA. 1996;276:549–54.PubMedGoogle Scholar
  34. 34.
    Dobnig H, Kainer F, Stepan V, Winter R, Lipp R, Schaffer M, et al. Elevated parathyroid hormone-related peptide levels after human gestation: Relationship to changes in bone and mineral metabolism. J Clin Endocrinol Metab. 1995;80:3699–707.PubMedGoogle Scholar
  35. 35.
    Szulc P, Hofbauer LC, Heufelder AE, Roth S, Delmas PD. Osteoprotegerin serum levels in men: correlation with age, estrogen, and testosterone status. J Clin Endocrinol Metab. 2001;86:3162–5.PubMedGoogle Scholar
  36. 36.
    Hayslip CC, Dlein TA, Wray L, Duncan WE. The effects of lactation on bone mineral content in healthy postpartum women. Obstet Gynecol. 1989;73:588–92.PubMedGoogle Scholar
  37. 37.
    Sowers MF, Randolph J, Shapiro B, Jannausch M. A prospective study of bone density and pregnancy after an extended period of lactation with bone loss. Obstet Gynecol. 1995;85:285–9.PubMedGoogle Scholar
  38. 38.
    Sowers MF, Corton G, Shapiro B, Jannausch ML, Crutchfield M, Smith ML, et al. Changes in bone density with lactation. JAMA. 1993;269:3130–5.PubMedGoogle Scholar
  39. 39.
    Kalkwarf HJ, Specker BL. Bone mineral loss during lactation and recovery during weaning. Obstet Gynecol. 1995;86:26–32.PubMedGoogle Scholar
  40. 40.
    Lopez JM, Gonzalez G, Reyes V, Campino C, Diaz S. Bone turnover and density in healthy women during breastfeeding and after weaning. Osteoporos Int. 1996;6:153–9.PubMedGoogle Scholar
  41. 41.
    Kolthoff N, Eiken P, Kristensen B, Nielsen SP. Bone mineral changes during pregnancy and lactation: a longitudinal cohort study. Clin Sci (Lond). 1998;94:405–12.Google Scholar
  42. 42.
    Hopkinson JM, Butte NF, Ellis K, Smith EO. Lactation delays postpartum bone mineral accretion and temporarily alters its regional distribution in women. J Nutr. 2000;130:777–83.PubMedGoogle Scholar
  43. 43.
    Polatti F, Capuzzo E, Viazzo F, Collconi R, Klersy C. Bone mineral changes during and after lactation. Obstet Gynecol. 1999;94:52–6.PubMedGoogle Scholar
  44. 44.
    Prentice A, Jarjou LM, Cole TJ, Stirling DM, Dibba B, Fairweather-Tait S. Calcium requirements of lactating Gambian mothers: effects of a calcium supplement on breast-milk calcium concentration, maternal bone mineral content, and urinary calcium excretion. Am J Clin Nutr. 1995;62:58–67.PubMedGoogle Scholar
  45. 45.
    Kalkwarf HJ, Specker BL, Bianchi DC, Ranz J, Ho M. The effect of calcium supplementation on bone density during lactation and after weaning. N Engl J Med. 1997;337:523–8.PubMedGoogle Scholar
  46. 46.
    Cross NA, Hillman LS, Allen SH, Krasue GF. Changes in BMD and markers of bone remodeling during lactation and postweaning in women consuming high amounts of calcium. J Bone Miner Res. 1995;10:1312–20.PubMedGoogle Scholar
  47. 47.
    Chan GM, McMurry M, Westover K, Englebert-Fenton K, Thoman R. Effects of increased dietary calcium intake upon the calcium and bone mineral status of lactating adolescent and adult women. Am J Clin Nutr. 1987;46:319–23.PubMedGoogle Scholar
  48. 48.
    Greer FR, Garn SM. Loss of bone mineral content in lactating adolescents. J Pediatr. 1982;101:718–9.PubMedGoogle Scholar
  49. 49.
    Cunningham AS, Mazess RB. Bone mineral loss in lactating adolescents. J Pediatr. 1983;101:338–9.Google Scholar
  50. 50.
    Specker BL, Tsang RC, Ho ML. Changes in calcium homeostasis over the first year postpartum: effect of lactation and weaning. Obstet Gynecol. 1991;78:56–62.PubMedGoogle Scholar
  51. 51.
    Walker ARP, Richardson B, Walker F. The influence of numerous pregnancies and lactations on bone dimensions in South African Bantu and caucasian mothers. Clin Sci. 1972;42:189–96.PubMedGoogle Scholar
  52. 52.
    Henderson PH, Sower M, Kutzko KE, Jannausch ML. Bone mineral density in grand multiparous women with extended lactation. Am J Obstet Gynecol. 2000;182:1371–7.PubMedGoogle Scholar
  53. 53.
    Jarjou LMA, Laskey MA, Sawo Y, Goldberg GR, Cole TJ, Prentice A. Effect of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake. Am J Clin Nutr. 2010;92:450–7.PubMedCentralPubMedGoogle Scholar
  54. 54.
    Khastgir G, Studd JWW, King H, Abdalla H, Jones J, Carter G, et al. Changes in bone density and biochemical markers of bone turnover in pregnancy-associated osteoporosis. Br J Obstet Gynaecol. 1996;103:716–8.PubMedGoogle Scholar
  55. 55.
    Gruber HE, Gutteridge DH, Baylink DJ. Osteoporosis associated with pregnancy and lactation: bone biopsy and skeletal features in three patients. Metab Bone Dis Relat Res. 1984;5:159–65.PubMedGoogle Scholar
  56. 56.
    Aloia JF, Vaswani AN, Yeh JK, Ross P, Ellis K, Cohn SH. Determinants of bone mass in postmenopausal women. Arch Intern Med. 1983;143:1700–4.PubMedGoogle Scholar
  57. 57.
    Feldblum PJ, Zhang J, Rich LE, Forney JA, Talmage RV. Lactation history and bone mineral density among perimenopausal women. Epidemiology. 1992;3:527–31.PubMedGoogle Scholar
  58. 58.
    Hreshchyshyn MM, Hopkins A, Zylstra S, Anbar M. Associations of parity, breast-feeding, and birth control pills with lumbar spine and femoral neck bone densities. Am J Obstet Gynecol. 1988;159:318–22.PubMedGoogle Scholar
  59. 59.
    Melton III LJ, Bryant SC, Wahner HW, O’Fallon WM, Malkasian GD, Judd HL, et al. Influence of breastfeeding and other reproductive factors on bone mass later in life. Osteoporos Int. 1993;3:76–83.PubMedGoogle Scholar
  60. 60.
    Schnatz PF, Barker KG, Marakovits KA, O’Sullivan DM. Effects of age at first pregnancy and breast-feeding on the development of postmenopausal osteoporosis. Menopause. 2010;17:1161–6.PubMedGoogle Scholar
  61. 61.
    Lissner L, Bengtsson C, Hansson T. Bone mineral content in relation to lactation history in pre- and postmeopausal women. Calcif Tissue Int. 1991;48:319–25.PubMedGoogle Scholar
  62. 62.
    Wardlaw GM, Pke AM. The effect of lactation on peak adult shaft and ultra-distal forearm bone mass in women. Am J Clin Nutr. 1986;44:283–6.PubMedGoogle Scholar
  63. 63.
    Koetting CA, Wardlaw GM. Wrist, spine, and hip bone density in women with variable histories of lactation. Am J Clin Nutr. 1988;48:1479–81.PubMedGoogle Scholar
  64. 64.
    Wasnich R, Yano K, Vogel J. Postmenopausal bone loss at multiple skeletal sites: Relationship to estrogen use. J Chronic Dis. 1983;36:781–90.PubMedGoogle Scholar
  65. 65.
    Cummings SR, Black DM, Nevitt MC, Browner W, Cauley J, Ensrud K, et al. Bone density at various sites for prediction of hip fractures. Lancet. 1993;341:72–5.Google Scholar
  66. 66.
    World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. 1994.Google Scholar
  67. 67.
    Specker B, Binkley T. High parity is associated with increased bone strength and size. Osteoporos Int. 2005;16:1969–74.PubMedGoogle Scholar
  68. 68.
    Turan V. Grand-grand multiparity (more than 10 deliveries) does not convey a risk for osteoporosis. Acta Obstet Gynecol Scand. 2011;90:1440–2.PubMedGoogle Scholar
  69. 69.
    Wiklund PK, Xu L, Wang Q, Mikkola T, Lyytikaeinen A, Voelgi E, et al. Lactation is associated with greater maternal bone size and bone strength later in life. Osteoporos Int. 2012;23:1939–45.PubMedGoogle Scholar
  70. 70.
    Alderman BW, Weiss NS, Daling JR, Ure CL, Ballard JH. Reproductive history and postmenopausal risk of hip and forearm fracture. Am J Epidemiol. 1986;124:262–7.PubMedGoogle Scholar
  71. 71.
    Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, et al. Risk factors for hip fracture in white women. N Engl J Med. 1995;332:767–73.PubMedGoogle Scholar
  72. 72.
    Hoffman S, Grisso JA, Kelsey JL, Gammon DM, O’Brien LA. Parity, lactation and hip fracture. Osteoporos Int. 1993;3:171–6.PubMedGoogle Scholar
  73. 73.
    Cumming RG, Klineberg RJ. Breastfeeding and other reproductive factors and the risk of hip fractures in elderly women. Int J Epidemiol. 1993;22:684–91.PubMedGoogle Scholar
  74. 74.
    Kreiger N, Kelsey JL, Holford TR, O’Connor T. An epidemiologic study of hip fracture in postmenopausal women. Am J Epidemiol. 1982;116:141–8.PubMedGoogle Scholar
  75. 75.
    Michaelsson K, Baron JA, Farahmand BY, Ljunghall S. Influence of parity and lactation on hip fracture risk. Am J Epidemiol. 2001;153:1166–72.PubMedGoogle Scholar
  76. 76.
    Buppasiri P, Lumbiganon P, Thinkhamrop J, Ngamjarus C, Laopaiboon M. Calcium supplementation (other than for preventing or treating hypertension) for improving pregnancy and infant outcomes. Cochrane database of systematic. Hoboken, NJ: Wiley; 2011.Google Scholar
  77. 77.
    Young BE, McNanley TJ, Cooper EM, McIntyre AW, Witter F, Harris ZL, et al. Maternal vitamin D status and calcium intake interact to affect fetal skeletal growth in utero in pregnant adolescents. Am J Clin Nutr. 2012;95:1103–12.PubMedCentralPubMedGoogle Scholar
  78. 78.
    Raman L, Rajalakshmi K, Krishnamachari KAVR, Sastry JG. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr. 1978;31:466–9.PubMedGoogle Scholar
  79. 79.
    Koo W, Walters J, Esterlitz J, Levine R, Bush A, Sibai B. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol. 1999;94:577–82.PubMedGoogle Scholar
  80. 80.
    Markestad T, Aksnes L, Ulstein M, Aarskog D. 25-Hydroxyvitamin D and 1,25-dihydroxyvitamin D of D2 and D3 origin in maternal and umbilical cord serum after vitamin D2 supplementation in human pregnancy. Am J Clin Nutr. 1984;40:1057–63.PubMedGoogle Scholar
  81. 81.
    Gertner JH, Glassman MC, Coustan DR, Goodman DB. Fetomaternal vitamin D relationships at term. J Pediatr. 1980;97:637–40.PubMedGoogle Scholar
  82. 82.
    Daaboul J, Sanderson S, Kristensen K, Kitson H. Vitamin D deficiency in pregnant and breast-feeding women and their infants. J Perinatol. 1997;17:10–4.PubMedGoogle Scholar
  83. 83.
    Okonofua F, Menon RK, Houlder S, Thomas M, Robinson D, O’Brien S, et al. Parathyroid hormone and neonatal calcium homeostasis: evidence for secondary hyperparathyroidism in the Asian neonate. Metabolism. 1986;35:803–6.PubMedGoogle Scholar
  84. 84.
    Purvis RJ, MacKay GS, Cockburn F, Barrie WJM, Wilkinson EM, Belton NR, et al. Enamel hypoplasia of the teeth associated with neonatal tetany: a manifestation of maternal vitamin D deficiency. Lancet. 1973;2:811–4.PubMedGoogle Scholar
  85. 85.
    Hollis B, Johnson D, Hulsey TC, Ebeling M, Wagner C. Vitamin D supplementation during pregnancy: double-blind, randomized clinical trial of safety and effectiveness. J Bone Miner Res. 2011;26:2341–57.PubMedCentralPubMedGoogle Scholar
  86. 86.
    Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS. Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr. 1986;109:328–34.PubMedGoogle Scholar
  87. 87.
    Brooke DG, Brown IRF, Bone CDM, Carter ND, Cleeve HJW, Maxwell JD, et al. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br J Med. 1980;280:751–4.Google Scholar
  88. 88.
    Leffelaar ER, Vrijkotte TG, van Eijsden M. Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam born children and their development cohort. Br J Nutr. 2010;104:108–17.PubMedGoogle Scholar
  89. 89.
    Bodnar LM, Catov JM, Zmuda JM, Cooper ME, Parrott MS, Roberts JM, et al. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr. 2010;140(5):999–1006.PubMedCentralPubMedGoogle Scholar
  90. 90.
    Morley R, Carlin JB, Pasco JA, Wark JD, Ponsonby AL. Maternal 25-hydroxyvitamin D concentration and offspring birth size: effect modification by infant VDR genotype. Eur J Clin Nutr. 2008;63:802–4.PubMedGoogle Scholar
  91. 91.
    Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn C, et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr. 2008;62:68–77.PubMedCentralPubMedGoogle Scholar
  92. 92.
    Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, et al. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. 2006;367:36–43.PubMedGoogle Scholar
  93. 93.
    Sayers AA, Tobias JH. Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child. J Clin Endocrinol Metab. 2009;94:765–71.PubMedCentralPubMedGoogle Scholar
  94. 94.
    De-Regil LM, Palacios C, Ansary A, Kulier R, Pena-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2012;2.Google Scholar
  95. 95.
    Zhou H. Rickets in China. In: Glorieux FH, editor. Rickets. New York, NY: Raven; 1991. p. 253.Google Scholar
  96. 96.
    Russell JGB, Hill LF. True fetal rickets. Br J Radiol. 1974;47:732–4.PubMedGoogle Scholar
  97. 97.
    Moncrief M, Fadahunsi TO. Congenital rickets due to maternal vitamin D deficiency. Arch Dis Child. 1974;49:810–1.Google Scholar
  98. 98.
    Reif S, Katzir Y, Eisenberg Z, Weisman Y. Serum 25-hydroxyvitamin D levels in congenital craniotabes. Acta Paediatr Scand. 1988;77:167–8.PubMedGoogle Scholar
  99. 99.
    Congdon P, Horsman A, Kirby PA, Dibble J, Bashir T. Mineral content of the forearms of babies born to Asian and white mothers. BMJ. 1983;286:1234–5.Google Scholar
  100. 100.
    Specker B, Ho M, Oestreich A, Yin T, Shui Q, Chen X, et al. Prospective study of vitamin D supplementation and rickets in China. J Pediatr. 1992;120:733–9.PubMedGoogle Scholar
  101. 101.
    Mahon P, Harvey N, Crozier S, Inskip H, Robinson S, Arden N, et al. Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res. 2010;25:14–9.PubMedGoogle Scholar
  102. 102.
    Ioannou C, Javaid MK, Mahon P, Yaqub MK, Harvey NC, Godfrey KM, et al. The effect of maternal vitamin D concentration on fetal bone. J Clin Endocrinol Metab. 2012;97:E2070–7.PubMedCentralPubMedGoogle Scholar
  103. 103.
    Viljakainen HT, Saarnio E, Hytinantti T, Miettinen M, Surcel H, Makitie O, et al. Maternal vitamin D status determines bone variables in the newborn. J Clin Endocrinol Metabol. 2010;95(4):1749–57.Google Scholar
  104. 104.
    Weiler H, Fitzpatrick-Wong S, Veitch R, Kovacs H, Schellenberg J, McCloy U, et al. Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. Can Med Assoc J. 2005;172:757–61.Google Scholar
  105. 105.
    Hollis BW, Roos BA, Draper HH, Lambert PW. Vitamin D and its metabolites in human and bovine milk. J Nutr. 1981;111:1240–8.PubMedGoogle Scholar
  106. 106.
    Specker BL, Tsang RC, Hollis BW. Effect of race and diet on human milk vitamin D and 25-hydroxyvitamin D. Am J Dis Child. 1985;139:1134–7.PubMedGoogle Scholar
  107. 107.
    Specker B, Valanis B, Hertzberg V, Edwards N, Tsang R. Sunshine exposure and serum 25-hydroxyvitamin D concentrations in exclusively breast-fed infants. J Pediatr. 1985;107:372.PubMedGoogle Scholar
  108. 108.
    Specker B, Tsang R. Cyclical serum 25-hydroxyvitamin D concentrations paralleling sunshine exposure in exclusively breast-fed infants. J Pediatr. 1987;110:744–7.PubMedGoogle Scholar
  109. 109.
    Basile LA, Taylor SN, Wagner C, Horst RL, Hollis BW. The effect of high-dose vitamin D supplementation on serum vitamin D levels and milk calcium concentration in lactating women and their infants. Breastfeed Med. 2006;1:27–35.PubMedGoogle Scholar
  110. 110.
    Ala-Houhala M. 25-Hydroxyvitamin D levels during breast-feeding with or without maternal or infantile supplementation of vitamin D. J Pediatr Gastroenterol Nutr. 1985;4:220–6.PubMedGoogle Scholar
  111. 111.
    Brooke OG, Butters F, Wood C. Intrauterine vitamin D nutrition and postnatal growth in Asian infants. BMJ. 1981;283:1024.PubMedCentralPubMedGoogle Scholar
  112. 112.
    Wey HE, Binkley T, Beare T, Wey CL, Specker B. Cross-sectional versus longitudinal associations of lean and fat mass with pQCT bone outcomes in children. J Clin Endocrinol Metab. 2011;96:106–14.PubMedCentralPubMedGoogle Scholar
  113. 113.
    Tobias JH, Steer CD, Emmett PM, Tonkin RJ, Cooper C, Ness AR. Bone mass in childhood is related to maternal diet in pregnancy. Osteoporos Int. 2005;16:1731–41.PubMedGoogle Scholar
  114. 114.
    Institute of Medicine (IOM). Dietary reference intakes for calcium and vitamin D. Washington, DC: The National Academies Press; 2011.Google Scholar
  115. 115.
    Jia X, Aucott LS, McNeill G. Nutritional status and subsequent all-cause mortality in men and women aged 75 years or over living in the community. Br J Nutr. 2007;98:593–9.PubMedGoogle Scholar
  116. 116.
    Sempos CT, Durazo-Arvizu RA, Dawson-Hughes B, Yetley EA, Looker AC, Schleicher RL, et al. Is there a reverse J-shaped association between 25-hydroxyvitamin D and all-cause mortality? Results from the U.S. nationally representative NHANES. J Clin Endocrinol Metab. 2013;98:3001–9.PubMedCentralPubMedGoogle Scholar
  117. 117.
    Javaid MK, Shore SR, Taylor P, Gale C, Boucher BJ, Noonan K, et al. Maternal vitamin D status during late pregnancy and accrual of childhood bone mienral (abstract #1047). J Bone Miner Res. 2003;18:S13.Google Scholar

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Ethel Austin Martin Program in Human NutritionSouth Dakota State UniversityBrookingsUSA

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