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Intrathecal Therapy for Nonmalignant and Malignant Abdominal Pain

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Chronic Abdominal Pain

Abstract

In patients who have not achieved adequate pain control with pharmacological therapy, the use of intrathecal therapy is a very safe and useful alternative. Catheter tip placement, drug or combinations to be used, and rate of administration are critical factors to guarantee a high success rate. Moreover, a trial via an epidural infusion is also very important as part of the strategy to appropriately assess the appropriate requirements of the patient to both improve the quality of analgesia, and decrease the incidence of side effects. Complications and side effects are rare if an appropriate technique and protocols are utilized. This chapter describes the steps that we have found are critical for the success of this therapy.

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References

  1. American Pain Society. Principles of Analgesic use in the treatment of acute pain and chronic cancer pain. 3rd ed. Skokie: APS; 1992.

    Google Scholar 

  2. Jacox A, Carr DB, Payne R, et al. New clinical-practice guidelines for the management of pain in patients with cancer. N Engl J Med. 1994;330(9):651–5.

    Article  CAS  PubMed  Google Scholar 

  3. Zech DFG, Grong S, Lynch J, et al. Validation of the World Health Organization guidelines for cancer pain relief: a 10-year prospective study. Pain. 1996;63:65–76.

    Article  Google Scholar 

  4. Ferrell BR, Wisdon C, Wenzl C. Quality of life as an outcome variable in management of cancer pain. Cancer. 1989;63:2321.

    Article  CAS  PubMed  Google Scholar 

  5. Liebeskind JC. Pain can kill. Pain. 1991;44:3–4.

    Article  CAS  PubMed  Google Scholar 

  6. Lillemoe KD, Cameron JL, Kaufman HS, et al. Chemical splanchnicectomy in patients with unresectable pancreatic cancer. Ann Surg. 1993;217:447–57.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Cousins MJ, Mather LE. Intrathecal and epidural administration of opioids. Anesthesiology. 1984;61:276–310.

    Article  CAS  PubMed  Google Scholar 

  8. Yaksh TL. Spinal opiates: a review of their effect on spinal function with an emphasis on pain processing. Acta Anaesthesiol Scand. 1987;31 Suppl 85:25.

    Article  Google Scholar 

  9. Du Pen S, Kharasch ED, Williams A, et al. Chronic epidural bupivacaine-opioid infusion in intractable cancer pain. Pain. 1992;49:293–300.

    Article  PubMed  Google Scholar 

  10. Wallace MS, Kosek PS, Staats P, Fisher R, Schultz DM, Leong M. Phase II, open-label, multicenter study of combined intrathecal morphine and ziconotide: addition of ziconotide in patients receiving intrathecal morphine for severe chronic pain. Pain Med. 2008;9:271–81.

    Article  PubMed  Google Scholar 

  11. Smith TJ, Staats PS, Deer T, et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: impact on pain, drug-related toxicity and survival. J Clin Oncol. 2002;20:4040–9.

    Article  CAS  PubMed  Google Scholar 

  12. Smith TJ, Coyne PJ. Implantable drug delivery systems (IDDS) after failure of comprehensive medical management(CMM) can palliate symptoms in the most refractory cancer pain patients. J Palliat Med. 2005;8:736–42.

    Article  PubMed  Google Scholar 

  13. Bedder MD, Burchiel KJ, Larson A. Cost analysis of two implantable narcotic delivery systems. J Pain Symptom Manage. 1991;6(6):368–73.

    Article  CAS  PubMed  Google Scholar 

  14. Hassenbusch SJ, Bedder M, Patt RB, Bell GK. Current status of intrathecal therapy for nonmalignant pain management: clinical realities and economic unknowns. J Pain Symptom Manage. 1997;14:S36–48.

    Article  CAS  PubMed  Google Scholar 

  15. Deer T, Krames ES, Hassenbusch SJ, et al. Polyanalgesic consensus conference 2007: recommendations for the management of pain by intrathecal (intraspinal) drug delivery: report of an interdisciplinary expert panel. Neuromodulation. 2007;10:300–28.

    Article  PubMed  Google Scholar 

  16. Johansen MJ, Satterfield WC, Baze WB, Hildebrand KR, Gradert TL, Hassenbusch SJ. Continuous intrathecal infusion of hydromorphone: safety in the sheep model and clinical implications. Pain Med. 2004;5:14–25.

    Article  PubMed  Google Scholar 

  17. Liu S, Chiu AA, Neal JM, Carpenter RL, Bainton BG, Gerancher JC. Oral clonidine prolongs lidocaine spinal anesthesia in human volunteers. Anesthesiology. 1995;82(6):1353–9.

    Article  CAS  PubMed  Google Scholar 

  18. Perren F, Buchser E, Chedel D, Hirt L, Maeder P, Vingerhoets F. Spinal cord lesion after long-term intrathecal clonidine and bupivacaine treatment for the management of intractable pain. Pain. 2004;109:189–94.

    Article  CAS  PubMed  Google Scholar 

  19. Bernard CM. Cerebrospinal fluid and spinal cord distribution of Baclofen and bupivacaine during slow intrathecal infusion in pigs. Anesthesiology. 2006;105:169–78.

    Article  Google Scholar 

  20. Kotob F, de Leon-Casasola OA, Lema M. Intrathecal infusion rates of 1 ml/day improve narrow analgesia with infusion rates of 0.5 ml/day. Anesthesiology. 2006;105:A347.

    Google Scholar 

  21. Hassenbusch S, Portenoy R, Cousins M, et al. Polyanalgesic consensus conference: an update on the management of pain by intraspinal drug delivery – report of an expert panel. J Pain Symptom Manage. 2004;27:540–63.

    Article  PubMed  Google Scholar 

  22. Staats PS, Yearwood T, Charapata SG, et al. Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS. A randomized controlled trial. JAMA. 2004;291:63–70.

    Article  CAS  PubMed  Google Scholar 

  23. Wallace MS, Rauck R, Fisher R, et al. Intrathecal ziconotide for severe chronic pain: safety and tolerability results of an open-label, long-term trial. Anesth Analg. 2008;106:628–37.

    Article  CAS  PubMed  Google Scholar 

  24. Webster LR, Fakata KL, Fisher R, MineHart M. Open-label multicenter study of combined intrathecal morphine and ziconotide: addition of morphine in patients receiving ziconotide for severe chronic pain. Pain Med. 2008;9:282–90.

    Article  PubMed  Google Scholar 

  25. Wallace M, Charapata S, Fisher R, et al. Intrathecal ziconotide in the treatment of chronic nonmalignant pain: a randomized double-blind placebo-controlled trial. Neuromodulation. 2006;9:75–86.

    Article  PubMed  Google Scholar 

  26. Rauck RL, Wallace MS, Leong MS, et al. A Randomized, double-blind, placebo-controlled study of intrathecal ziconotide in adults with severe chronic pain. J Pain Symp Manage. 2006;5:393–406.

    Article  Google Scholar 

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Correspondence to Oscar A. de Leon-Casasola M.D. .

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de Leon-Casasola, O.A. (2015). Intrathecal Therapy for Nonmalignant and Malignant Abdominal Pain. In: Kapural, L. (eds) Chronic Abdominal Pain. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1992-5_22

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  • DOI: https://doi.org/10.1007/978-1-4939-1992-5_22

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1991-8

  • Online ISBN: 978-1-4939-1992-5

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