Novel Molecules

  • Valeria Lourdes Vukelic
  • Marcelo Orias
Part of the Clinical Hypertension and Vascular Diseases book series (CHVD)


Novel approaches and drugs to improve hypertension treatment are permanently under investigation. Human recombinant renalase is being tested in animal models and new options to block the renin–angiotensin–aldosterone axis such as renin inhibitors, angiotensin II type 2 receptor agonists, angiotensin vaccines and aldosterone synthase inhibitors are under scrutiny with variable results so far. Interventions in different hormones and autacoids, enzymatic and cellular signalling pathways like vasopeptidase inhibitors, activators and stimulators of soluble guanylyl cyclase, soluble epoxide hydrolase inhibitors and endothelin receptor antagonists, among others, are all work in progress. Objectives with newer agents are to optimize blood pressure control and minimize end-organ damage beyond what has been achieved so far. Adverse effects will limit some of these new therapeutic approaches.


Hypertension Drugs Angiotensin Aldosterone Renalase Renin Prostaglandin Nitric oxide Endothelin 



Compound 21


Cyclic guanosine 3′,5′-monophosphate




Cytochrome P-450


Endothelin 1


Endothelin 2


Endothelin 3


Endothelin receptor type A


Endothelin receptor type B


Epoxyeicosatrienoic acids


Endothelin receptor antagonist


Food and Drug Administration


Hydroxyeicosatetraenoic acids










Mineralocorticoid receptors


Neutral endopeptidase


Nitric oxide


Soluble epoxide hydrolase


Soluble guanylyl cyclase


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of NephrologySanatorio Allende CordobaCordobaArgentina

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