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The Front Matter has been revised. It now includes a Foreword by the book series editor.

FOREWORD

The importance of hypertension as it relates to chronic kidney disease and end stage renal disease (ESRD) has been greatly appreciated by physicians and scientists for more than 60 years and reinforced during the clinical trials that followed in the 1990s and the first decade of this century. This appreciation of the severity of the complications of this common disorder, particularly in patients with comorbidities such as diabetes mellitus, has led to improvement in the rates of ESRD and kidney-related mortality over the past 30 years. Nevertheless, there is ample room for improvement and chronic kidney disease associated with hypertension and other vascular disorders remain an extremely important problem in clinical medicine. Drs. Weir and Lerma’s volume on Chronic Kidney Disease and Hypertension is a highly relevant contribution in the area of clinical nephrology - this book brings together the pathophysiologic, epidemiologic, diagnostic, and therapeutic advances in the evaluation of hypertension in patients with chronic kidney disease and related disorders.

The editors have organized this volume into areas that cover the general pathophysiology and guideline-based recommendations to managing hypertension, and various means to evaluate blood pressure phenotypes by ambulatory and home/selfmonitoring as well as central blood pressure assessment. Pharmacologic and device therapy approaches to the management of resistant hypertension and patients with chronic kidney disease are also given substantial attention in this book. Additionally, there are comprehensive chapters on the neurogenic factors in chronic kidney disease, dual renin-angiotensin inhibition and novel molecules and blood pressure vaccine therapy.

Weir and Lerma have also provided interesting chapters devoted to special problems in clinical hypertension that highlight problems which are of particular concern to hypertension specialists, including white-coat and masked hypertension and special populations such as adolescents, pregnancy, and obstructive sleep apnea. These sections contribute to the uniqueness of this book since the chapters are grounded in clinical investigations that have led to enhanced understanding of the evaluation and treatment of hypertension in these special populations. Important basic or translational chapters involving research in inflammation, the sympathetic nervous system, uric acid, and genomics are featured by basic investigators who have spent their careers performing research in these specific areas.

The chapters in Chronic Kidney Disease and Hypertension have been composed by a number of well-known, expert authors who have provided comprehensive, scientifically sound, and clinically appropriate information. As series editor of Clinical Hypertension and Vascular Diseases, I am pleased by the publication of this timely and clinically relevant book and know that Chronic Kidney Disease and Hypertension will become a useful textbook for any specialist in nephrology and vascuiar medicine as well as any physician who take care of patients with severe and resistant hypertension.

William B. White, M.D,

Series Editor, Clinical Hypertension and Vascular Diseases

Professor of Medicine and Chief, Division of Hypertension and Clinical Pharmacology

Calhoun Cardiology Center

University of Connecticut School of Medicine, Farmington

The online version of the original book can be found at

http://dx.doi.org/ 10.1007/978-1-4939-1982-6