Pregnancy and Substance Abuse

  • Gulshan Doulatram
  • Tilak D. Raj
  • Ranganathan Govindaraj

Abstract

Substance abuse is increasing in incidence worldwide, including pregnant women who are highly vulnerable to its effects. Pregnant women should be screened routinely for substance abuse. Because self-report may be unreliable, toxicology screens can be useful, especially if multiple drugs are being abused. Each individual drug has unique maternal and fetal effects. Licit substances such as alcohol, nicotine, and caffeine are more frequently abused. Complete cessation of alcohol should be encouraged to avoid the development of Fetal Alcohol Syndrome (FAS) and long-term neurobehavioral effects. Marijuana is the most commonly abused illicit drug. Opioid maintenance programs can be utilized in opioid addicted patients (including heroin and cocaine) to avoid relapses. Neonatal abstinence syndrome should be expected in these infants and managed appropriately.

Keywords

Pregnancy Substance abuse Definition TACE questionnaire TWEAK questionnaire AUDIT questionnaire Toxicology testing Perinatal management Fetal alcohol syndrome 

References

  1. 1.
    Wong S, Ordean A, Kahan M. Substance use in pregnancy. J Obstet Gynaecol Can. 2011;33(4):367–84.PubMedGoogle Scholar
  2. 2.
    Harwell TS, Spence MR, Sands A, Iguchi MY. Substance use in an inner-city family planning population. J Reprod Med. 1996;41(9):704–10.PubMedGoogle Scholar
  3. 3.
    Ostrea Jr EM, Knapp DK, Tannenbaum L, Ostrea AR, Romero A, Salari V, et al. Estimates of illicit drug use during pregnancy by maternal interview, hair analysis, and meconium analysis. J Pediatr. 2001;138(3):344–8.PubMedGoogle Scholar
  4. 4.
    Behnke M, Smith VC. Prenatal substance abuse: short- and long-term effects on the exposed fetus. Pediatrics. 2013;131(3):e1009–24.PubMedGoogle Scholar
  5. 5.
    Jones HE, Finnegan LP, Kaltenbach K. Methadone and buprenorphine for the management of opioid dependence in pregnancy. Drugs. 2012;72(6):747–57.PubMedGoogle Scholar
  6. 6.
    Wendell AD. Overview and epidemiology of substance abuse in pregnancy. Clin Obstet Gynecol. 2013;56(1):91–6.PubMedGoogle Scholar
  7. 7.
    Substance Abuse and Mental Health Services Administration. Results from the 2010 national survey on drug use and health: summary of national findings. HHS Publication No. (SMA) 11-4658. Rockville: Substance Abuse and Mental Health Services Administration; 2011.Google Scholar
  8. 8.
    Keegan J, Parva M, Finnegan M, Gerson A, Belden M. Addiction in pregnancy. J Addict Dis. 2010;29(2):175–91.PubMedGoogle Scholar
  9. 9.
    Arria AM, Derauf C, Lagasse LL, Grant P, Shah R, Smith L, et al. Methamphetamine and other substance use during pregnancy: preliminary estimates from the Infant Development, Environment, and Lifestyle (IDEAL) study. Matern Child Health J. 2006;10(3):293–302.PubMedGoogle Scholar
  10. 10.
    Landau R, Cahana A, Smiley RM, Antonarakis SE, Blouin JL. Genetic variability of mu-opioid receptor in an obstetric population. Anesthesiology. 2004;100(4):1030–3.PubMedGoogle Scholar
  11. 11.
    Calhoun F, Attilia ML, Spagnolo PA, Rotondo C, Mancinelli R, Ceccanti M. National Institute on Alcohol Abuse and Alcoholism and the study of fetal alcohol spectrum disorders. The International Consortium. Ann Ist Super Sanita. 2006;42(1):4–7.PubMedGoogle Scholar
  12. 12.
    Schempf AH, Strobino DM. Illicit drug use and adverse birth outcomes: is it drugs or context? J Urban Health. 2008;85(6):858–73.PubMedCentralPubMedGoogle Scholar
  13. 13.
    Ludlow JP, Evans SF, Hulse G. Obstetric and perinatal outcomes in pregnancies associated with illicit substance abuse. Aust N Z J Obstet Gynaecol. 2004;44(4):302–6.PubMedGoogle Scholar
  14. 14.
    American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-V). 5th ed. Arlington: American Psychiatric Publishing; 2013.Google Scholar
  15. 15.
    Birnbach DJ, Browne IM, Kim A, Stein DJ, Thys DM. Identification of polysubstance abuse in the parturient. Br J Anaesth. 2001;87(3):488–90.PubMedGoogle Scholar
  16. 16.
    Morse B, Gehshan S, Hutchins E. Screening for substance abuse during pregnancy: improving care, improving health. Arlington: National Center for Education in Maternal and Child Health; 1997.Google Scholar
  17. 17.
    Washington State Department of Health. Substance abuse during pregnancy: guidelines for screening. Tumwater: Washington State Department of Health; 2013.Google Scholar
  18. 18.
    Howell EM, Heiser N, Harrington M. A review of recent findings on substance abuse treatment for pregnant women. J Subst Abuse Treat. 1999;16(3):195–219.PubMedGoogle Scholar
  19. 19.
    Chang G, Wilkins-Haug L, Berman S, Goetz MA. The TWEAK: application in a prenatal setting. J Stud Alcohol. 1999;60(3):306–9.PubMedGoogle Scholar
  20. 20.
    Carroll JC, Reid AJ, Biringer A, Midmer D, Glazier RH, Wilson L, et al. Effectiveness of the Antenatal Psychosocial Health Assessment (ALPHA) form in detecting psychosocial concerns: a randomized controlled trial. CMAJ. 2005;173(3):253–9.PubMedCentralPubMedGoogle Scholar
  21. 21.
    Ewing JA. Detecting alcoholism. The CAGE questionnaire. JAMA. 1984;252(14):1905–7.PubMedGoogle Scholar
  22. 22.
    Chasnoff IJ, Neuman K, Thornton C, Callaghan MA. Screening for substance use in pregnancy: a practical approach for the primary care physician. Am J Obstet Gynecol. 2001;184(4):752–8.PubMedGoogle Scholar
  23. 23.
    Chasnoff IJ, McGourty RF, Bailey GW, Hutchins E, Lightfoot SO, Pawson LL, et al. The 4P’s Plus screen for substance use in pregnancy: clinical application and outcomes. J Perinatol. 2005;25(6):368–74.PubMedGoogle Scholar
  24. 24.
    Chasnoff IJ, Wells AM, McGourty RF, Bailey LK. Validation of the 4P’s Plus screen for substance use in pregnancy validation of the 4P’s Plus. J Perinatol. 2007;27(12):744–8.PubMedGoogle Scholar
  25. 25.
    Yonkers KA, Gotman N, Kershaw T, Forray A, Howell HB, Rounsaville BJ. Screening for prenatal substance use: development of the Substance Use Risk Profile-Pregnancy scale. Obstet Gynecol. 2010;116(4):827–33.PubMedCentralPubMedGoogle Scholar
  26. 26.
    Harrison PA, Sidebottom AC. Systematic prenatal screening for psychosocial risks. J Health Care Poor Underserved. 2008;19(1):258–76.PubMedGoogle Scholar
  27. 27.
    Harrison PA, Godecker A, Sidebottom A. Validity of the prenatal risk overview for detecting drug use disorders in pregnancy. Public Health Nurs. 2012;29(6):563–73.PubMedGoogle Scholar
  28. 28.
    Fleming MF, Barry KL, MacDonald R. The alcohol use disorders identification test (AUDIT) in a college sample. Int J Addict. 1991;26(11):1173–85.PubMedGoogle Scholar
  29. 29.
    Hays RD, Merz JF, Nicholas R. Response burden, reliability, and validity of the CAGE, Short MAST, and AUDIT alcohol screening measures. Behav Res Methods Instrum Comput. 1995;27:277–80.Google Scholar
  30. 30.
    Veloso LU, de Souza MCF. Prevalence and factors associated with alcohol use among pregnant adolescents. Rev Lat Am Enfermagem. 2013;21(1):433–41.PubMedGoogle Scholar
  31. 31.
    Miller GA. The Substance Abuse Subtle Screening Inventory (SASSI) manual. 2nd ed. Springville: SASSI Institute; 1999.Google Scholar
  32. 32.
    Horrigan TJ, Piazza NJ, Weinstein L. The substance abuse subtle screening inventory is more cost effective and has better selectivity than urine toxicology for the detection of substance abuse in pregnancy. J Perinatol. 1996;16(5):326–30.PubMedGoogle Scholar
  33. 33.
    Horrigan TJ, Piazza N. The substance abuse subtle screening inventory minimizes the need for toxicology screening of prenatal patients. J Subst Abuse Treat. 1999;17(3):243–7.PubMedGoogle Scholar
  34. 34.
    Lozano J, Garcia-Algar O, Vall O, de la Torre R, Scaravelli G, Pichini S. Biological matrices for the evaluation of in utero exposure to drugs of abuse. Ther Drug Monit. 2007;29(6):711–34.PubMedGoogle Scholar
  35. 35.
    Garcia-Algar O, Vall O, Alameda F, Puig C, Pellegrini M, Pacifici R, et al. Prenatal exposure to arecoline (areca nut alkaloid) and birth outcomes. Arch Dis Child Fetal Neonatal Ed. 2005;90(3):F276–7.PubMedCentralPubMedGoogle Scholar
  36. 36.
    Pichini S, Altieri I, Zuccaro P, Pacifici R. Drug monitoring in nonconventional biological fluids and matrices. Clin Pharmacokinet. 1996;30(3):211–28.PubMedGoogle Scholar
  37. 37.
    Klein J, Karaskov T, Koren G. Clinical applications of hair testing for drugs of abuse—the Canadian experience. Forensic Sci Int. 2000;107(1–3):281–8.PubMedGoogle Scholar
  38. 38.
    Montgomery D, Plate C, Alder SC, Jones M, Jones J, Christensen RD. Testing for fetal exposure to illicit drugs using umbilical cord tissue vs meconium. J Perinatol. 2006;26(1):11–4.PubMedGoogle Scholar
  39. 39.
    Cirimele V, Kintz P, Mangin P. Drug concentrations in human hair after bleaching. J Anal Toxicol. 1995;19(5):331–2.PubMedGoogle Scholar
  40. 40.
    Land DB, Kushner R. Drug abuse during pregnancy in an inner-city hospital: prevalence and patterns. J Am Osteopath Assoc. 1990;90(5):421–6.PubMedGoogle Scholar
  41. 41.
    Halstead AC, Godolphin W, Lockitch G, Segal S. Timing of specimen collection is crucial in urine screening of drug dependent mothers and newborns. Clin Biochem. 1988;21(1):59–61.PubMedGoogle Scholar
  42. 42.
    Caplan YH, Goldberger BA. Alternative specimens for workplace drug testing. J Anal Toxicol. 2001;25(5):396–9.PubMedGoogle Scholar
  43. 43.
    Oei JL, Kingsbury A, Dhawan A, Burns L, Feller JM, Clews S, et al. Amphetamines, the pregnant woman and her children: a review. J Perinatol. 2012;32(10):737–47.PubMedGoogle Scholar
  44. 44.
    Ladhani NN, Shah PS, Murphy KE. Prenatal amphetamine exposure and birth outcomes: a systematic review and metaanalysis. Am J Obstet Gynecol. 2011;205(3):219–7.PubMedGoogle Scholar
  45. 45.
    Kuczkowski KM. The effects of drug abuse on pregnancy. Curr Opin Obstet Gynecol. 2007;19(6):578–85.PubMedGoogle Scholar
  46. 46.
    Ganapathy V. Drugs of abuse and human placenta. Life Sci. 2011;88(21–22):926–30.PubMedCentralPubMedGoogle Scholar
  47. 47.
    Jones HE, O’Grady KE, Tuten M. Reinforcement-based treatment improves the maternal treatment and neonatal outcomes of pregnant patients enrolled in comprehensive care treatment. Am J Addict. 2011;20(3):196–204.PubMedCentralPubMedGoogle Scholar
  48. 48.
    Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M. Effects of caffeine on human health. Food Addit Contam. 2003;20(1):1–30.PubMedGoogle Scholar
  49. 49.
    Browne ML. Maternal exposure to caffeine and risk of congenital anomalies: a systematic review. Epidemiology. 2006;17(3):324–31.PubMedGoogle Scholar
  50. 50.
    Weng X, Odouli R, Li DK. Maternal caffeine consumption during pregnancy and the risk of miscarriage: a prospective cohort study. Am J Obstet Gynecol. 2008;198(3):279–8.PubMedGoogle Scholar
  51. 51.
    Back SA, Craig A, Luo NL, Ren J, Akundi RS, Ribeiro I, et al. Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injury. Ann Neurol. 2006;60(6):696–705.PubMedGoogle Scholar
  52. 52.
    Centers for Disease Control and Prevention (CDC). Alcohol use and binge drinking among women of childbearing age—United States, 2006-2010. MMWR Morb Mortal Wkly Rep. 2012;61(28):534–8. 7-20-2012.Google Scholar
  53. 53.
    Pruett D, Waterman EH, Caughey AB. Fetal alcohol exposure: consequences, diagnosis, and treatment. Obstet Gynecol Surv. 2013;68(1):62–9.PubMedGoogle Scholar
  54. 54.
    Abel EL, Sokol RJ. A revised conservative estimate of the incidence of FAS and its economic impact. Alcohol Clin Exp Res. 1991;15(3):514–24.PubMedGoogle Scholar
  55. 55.
    Serdula M, Williamson DF, Kendrick JS, Anda RF, Byers T. Trends in alcohol consumption by pregnant women. 1985 through 1988. JAMA. 1991;265(7):876–9.PubMedGoogle Scholar
  56. 56.
    Hoyme HE, May PA, Kalberg WO, Kodituwakku P, Gossage JP, Trujillo PM, et al. A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria. Pediatrics. 2005;115(1):39–47.PubMedGoogle Scholar
  57. 57.
    Heberlein A, Leggio L, Stichtenoth D, Hillemacher T. The treatment of alcohol and opioid dependence in pregnant women. Curr Opin Psychiatry. 2012;25(6):559–64.PubMedGoogle Scholar
  58. 58.
    Grant TM, Brown NN, Dubovsky D, Sparrow J, Ries R. The impact of prenatal alcohol exposure on addiction treatment. J Addict Med. 2013;7(2):87–95.PubMedGoogle Scholar
  59. 59.
    Ghuran A, Nolan J. Recreational drug misuse: issues for the cardiologist. Heart. 2000;83(6):627–33.PubMedCentralPubMedGoogle Scholar
  60. 60.
    Sajo E. Pharmacology of substance abuse. Lippincotts Prim Care Pract. 2000;4(3):319–35.PubMedGoogle Scholar
  61. 61.
    Reynolds EW, Bada HS. Pharmacology of drugs of abuse. Obstet Gynecol Clin North Am. 2003;30(3):501–22.PubMedGoogle Scholar
  62. 62.
    Warner DO. Perioperative abstinence from cigarettes: physiologic and clinical consequences. Anesthesiology. 2006;104(2):356–67.PubMedGoogle Scholar
  63. 63.
    U.S. Department of Health and Human Services. The health consequences of smoking: a report of the Surgeon General. Washington, DC: Department of Health and Human Services; 2004.Google Scholar
  64. 64.
    American College of Obstetricians and Gynecologists. Smoking cessation during pregnancy. Obstet Gynecol. 2010;116:1241–4.Google Scholar
  65. 65.
    Hegaard HK, Kjaergaard H, Moller LF, Wachmann H, Ottesen B. The effect of environmental tobacco smoke during pregnancy on birth weight. Acta Obstet Gynecol Scand. 2006;85(6):675–81.PubMedGoogle Scholar
  66. 66.
    England LJ, Kendrick JS, Wilson HG, Merritt RK, Gargiullo PM, Zahniser SC. Effects of smoking reduction during pregnancy on the birth weight of term infants. Am J Epidemiol. 2001;154(8):694–701.PubMedGoogle Scholar
  67. 67.
    Public Health Service. Treating tobacco use and dependence. 2008. http://www.surgeongeneral.gov/tobacco/treating_tobacco_use08.pdf
  68. 68.
    Colman GJ, Joyce T. Trends in smoking before, during, and after pregnancy in ten states. Am J Prev Med. 2003;24(1):29–35.PubMedGoogle Scholar
  69. 69.
    Preventive Services US. Task Force. Counseling and interventions to prevent tobacco use and tobacco-caused disease in adults and pregnant women: U.S. Preventive Services Task Force reaffirmation recommendation statement. Ann Intern Med. 2009;150:551–5.Google Scholar
  70. 70.
    Windsor R, Oncken C, Henningfield J, Hartmann K, Edwards N. Behavioral and pharmacological treatment methods for pregnant smokers: issues for clinical practice. J Am Med Womens Assoc. 2000;55(5):304–10.PubMedGoogle Scholar
  71. 71.
    Swamy GK, Roelands JJ, Peterson BL, Fish LJ, Oncken CA, Pletsch PK, et al. Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial. Am J Obstet Gynecol. 2009;201(4):354–7.PubMedCentralPubMedGoogle Scholar
  72. 72.
    Pfizer Labs. Chantix® (varenicline) tablets: highlights of prescribing information. New York: Pfizer Labs; 2010. Ref Type: Pamphlet.Google Scholar
  73. 73.
    American College of Obstetricians and Gynecologists. Use of psychiatric medications during pregnancy and lactation. ACOG Practice Bulletin No. 92. Obstet Gynecol. 2008;111:1001–20.Google Scholar
  74. 74.
    U.S. Food Drug Administration. Information for healthcare professionals: varenicline (marketed as Chantix) and bupropion (marketed as Zyban, Wellbutrin, and generics). Rockville: U.S. Food and Drug Administration; 2010.Google Scholar
  75. 75.
    Porter LS, Porter BO. A blended infant massage—parenting enhancement program for recovering substance-abusing mothers. Pediatr Nurs. 2004;30(5):363–72. 401.PubMedGoogle Scholar
  76. 76.
    Kuczkowski KM. The cocaine abusing parturient: a review of anesthetic considerations. Can J Anaesth. 2004;51(2):145–54.PubMedGoogle Scholar
  77. 77.
    Keegan A. Cocaine plus alcohol, a deadly mix. NIDA Notes. 1991;6:18.Google Scholar
  78. 78.
    Om A, Ellahham S, DiSciascio G. Management of cocaine-induced cardiovascular complications. Am Heart J. 1993;125(2 Pt 1):469–75.PubMedGoogle Scholar
  79. 79.
    Chao CR. Cardiovascular effects of cocaine during pregnancy. Semin Perinatol. 1996;20(2):107–14.PubMedGoogle Scholar
  80. 80.
    Nahas GG, Trouve R, Manger WM. Cocaine, catecholamines and cardiac toxicity. Acta Anaesthesiol Scand Suppl. 1990;94:77–81.PubMedGoogle Scholar
  81. 81.
    Nanda A, Vannemreddy P, Willis B, Kelley R. Stroke in the young: relationship of active cocaine use with stroke mechanism and outcome. Acta Neurochir Suppl. 2006;96:91–6.PubMedGoogle Scholar
  82. 82.
    Blaho K, Winbery S, Park L, Logan B, Karch SB, Barker LA. Cocaine metabolism in hyperthermic patients with excited delirium. J Clin Forensic Med. 2000;7(2):71–6.PubMedGoogle Scholar
  83. 83.
    Woods Jr JR, Plessinger MA. Pregnancy increases cardiovascular toxicity to cocaine. Am J Obstet Gynecol. 1990;162(2):529–33.PubMedGoogle Scholar
  84. 84.
    Kuczkowski KM. Cardiovascular complications of recreational cocaine use in pregnancy: myth or reality? Acta Obstet Gynecol Scand. 2005;84(1):100–1.PubMedGoogle Scholar
  85. 85.
    Buehler BA. Cocaine: how dangerous is it during pregnancy? Nebr Med J. 1995;80(5):116–7.PubMedGoogle Scholar
  86. 86.
    Bhuvaneswar CG, Chang G, Epstein LA, Stern TA. Cocaine and opioid use during pregnancy: prevalence and management. Prim Care Companion J Clin Psychiatry. 2008;10(1):59–65.PubMedCentralPubMedGoogle Scholar
  87. 87.
    Bateman DA, Chiriboga CA. Dose-response effect of cocaine on newborn head circumference. Pediatrics. 2000;106(3):E33.PubMedGoogle Scholar
  88. 88.
    Kuczkowski KM. Peripartum care of the cocaine-abusing parturient: are we ready? Acta Obstet Gynecol Scand. 2005;84(2):108–16.PubMedGoogle Scholar
  89. 89.
    Bae S, Zhang L. Prenatal cocaine exposure increases apoptosis of neonatal rat heart and heart susceptibility to ischemia-reperfusion injury in 1-month-old rat. Br J Pharmacol. 2005;144(7): 900–7.PubMedCentralPubMedGoogle Scholar
  90. 90.
    Chaplin TM, Freiburger MB, Mayes LC, Sinha R. Prenatal cocaine exposure, gender, and adolescent stress response: a prospective longitudinal study. Neurotoxicol Teratol. 2010;32(6):595–604.PubMedCentralPubMedGoogle Scholar
  91. 91.
    Bingol N, Fuchs M, Diaz V, Stone RK, Gromisch DS. Teratogenicity of cocaine in humans. J Pediatr. 1987;110(1):93–6.PubMedGoogle Scholar
  92. 92.
    Handler A, Kistin N, Davis F, Ferre C. Cocaine use during pregnancy: perinatal outcomes. Am J Epidemiol. 1991;133(8):818–25.PubMedGoogle Scholar
  93. 93.
    Chasnoff IJ, Chisum GM, Kaplan WE. Maternal cocaine use and genitourinary tract malformations. Teratology. 1988;37(3):201–4.PubMedGoogle Scholar
  94. 94.
    Williams JH, Ross L. Consequences of prenatal toxin exposure for mental health in children and adolescents: a systematic review. Eur Child Adolesc Psychiatry. 2007;16(4):243–53.PubMedGoogle Scholar
  95. 95.
    Bauer CR, Langer JC, Shankaran S, Bada HS, Lester B, Wright LL, et al. Acute neonatal effects of cocaine exposure during pregnancy. Arch Pediatr Adolesc Med. 2005;159(9): 824–34.PubMedGoogle Scholar
  96. 96.
    Paine TA, Jackman SL, Olmstead MC. Cocaine-induced anxiety: alleviation by diazepam, but not buspirone, dimenhydrinate or diphenhydramine. Behav Pharmacol. 2002;13(7):511–23.PubMedGoogle Scholar
  97. 97.
    Vidaeff AC, Mastrobattista JM. In utero cocaine exposure: a thorny mix of science and mythology. Am J Perinatol. 2003;20(4):165–72.PubMedGoogle Scholar
  98. 98.
    Higgins ST, Delaney DD, Budney AJ, Bickel WK, Hughes JR, Foerg F, et al. A behavioral approach to achieving initial cocaine abstinence. Am J Psychiatry. 1991;148(9):1218–24.PubMedGoogle Scholar
  99. 99.
    Hull L, May J, Farrell-Moore D, Svikis DS. Treatment of cocaine abuse during pregnancy: translating research to clinical practice. Curr Psychiatry Rep. 2010;12(5):454–61.PubMedGoogle Scholar
  100. 100.
    Kleber HD. Pharmacologic treatments for heroin and cocaine dependence. Am J Addict. 2003;12 Suppl 2:S5–18.PubMedGoogle Scholar
  101. 101.
    Bagasra O, Forman LJ, Howeedy A, Whittle P. A potential vaccine for cocaine abuse prophylaxis. Immunopharmacology. 1992;23(3):173–9.PubMedGoogle Scholar
  102. 102.
    Fox BS, Kantak KM, Edwards MA, Black KM, Bollinger BK, Botka AJ, et al. Efficacy of a therapeutic cocaine vaccine in rodent models. Nat Med. 1996;2(10):1129–32.PubMedGoogle Scholar
  103. 103.
    Kosten TR, Rosen M, Bond J, Settles M, Roberts JS, Shields J, et al. Human therapeutic cocaine vaccine: safety and immunogenicity. Vaccine. 2002;20(7–8):1196–204.PubMedGoogle Scholar
  104. 104.
    Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD, et al. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Mol Ther. 2011;19(3):612–9.PubMedCentralPubMedGoogle Scholar
  105. 105.
    Martell BA, Arnsten JH, Krantz MJ, Gourevitch MN. Impact of methadone treatment on cardiac repolarization and conduction in opioid users. Am J Cardiol. 2005;95(7):915–8.PubMedGoogle Scholar
  106. 106.
    Paula S, Tabet MR, Farr CD, Norman AB, Ball Jr WJ. Three-dimensional quantitative structure-activity relationship modeling of cocaine binding by a novel human monoclonal antibody. J Med Chem. 2004;47(1):133–42.PubMedGoogle Scholar
  107. 107.
    Norman AB, Norman MK, Buesing WR, Tabet MR, Tsibulsky VL, Ball WJ. The effect of a chimeric human/murine anti-cocaine monoclonal antibody on cocaine self-administration in rats. J Pharmacol Exp Ther. 2009;328(3):873–81.PubMedCentralPubMedGoogle Scholar
  108. 108.
    Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD, et al. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Hum Gene Ther. 2012;23(5):451–9.PubMedCentralPubMedGoogle Scholar
  109. 109.
    Danger Y, Devys A, Gadjou C, Galons H, Blanchard D, Follea G. Development of monoclonal antibodies directed against cocaine and cocaethylene: potential new tools for immunotherapy. Hybrid Hybridomics. 2004;23(4):212–8.PubMedGoogle Scholar
  110. 110.
    National Institute on Drug Abuse. NIDA survey provides first national data on drug use during pregnancy. 1995. http://archives.drugabuse.gov/NIDA_Notes/NNVol10N1/NIDASurvey.html. Accessed 1 July 2012.
  111. 111.
    Azadi A, Dildy III GA. Universal screening for substance abuse at the time of parturition. Am J Obstet Gynecol. 2008;198(5):e30–2.PubMedGoogle Scholar
  112. 112.
    Velez M, Jansson LM. The Opioid dependent mother and newborn dyad: non-pharmacologic care. J Addict Med. 2008;2(3):113–20.PubMedCentralPubMedGoogle Scholar
  113. 113.
    Fitzsimons HE, Tuten M, Vaidya V, Jones HE. Mood disorders affect drug treatment success of drug-dependent pregnant women. J Subst Abuse Treat. 2007;32(1):19–25.PubMedGoogle Scholar
  114. 114.
    Martin JA, Campbell A, Killip T, Kotz M, Krantz MJ, Kreek MJ, et al. QT interval screening in methadone maintenance treatment: report of a SAMHSA expert panel. J Addict Dis. 2011;30(4):283–306.PubMedCentralPubMedGoogle Scholar
  115. 115.
    Heil SH, Jones HE, Arria A, Kaltenbach K, Coyle M, Fischer G, et al. Unintended pregnancy in opioid-abusing women. J Subst Abuse Treat. 2011;40(2):199–202.PubMedCentralPubMedGoogle Scholar
  116. 116.
    Stoelting RK, Hillier S. Pharmacology and physiology in anesthetic practice. 4th ed. Philadelphia: Lippincott Williams and Wilkins; 2006.Google Scholar
  117. 117.
    Mello NK, Mendelson JH. Buprenorphine suppresses heroin use by heroin addicts. Science. 1980;207(4431):657–9.PubMedGoogle Scholar
  118. 118.
    Davis MP, Pasternak GW. Opioid receptors and opioid pharmaxodynamics. Oxford: Oxford University Press; 2013.Google Scholar
  119. 119.
    Johnson RE, Jones HE, Fischer G. Use of buprenorphine in pregnancy: patient management and effects on the neonate. Drug Alcohol Depend. 2003;70(2 Suppl):S87–101.PubMedGoogle Scholar
  120. 120.
    Volkow ND, Wang GJ, Fowler JS, Tomasi D, Telang F. Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci USA. 2011;108(37):15037–42.PubMedCentralPubMedGoogle Scholar
  121. 121.
    Pickens CL, Airavaara M, Theberge F, Fanous S, Hope BT, Shaham Y. Neurobiology of the incubation of drug craving. Trends Neurosci. 2011;34(8):411–20.PubMedCentralPubMedGoogle Scholar
  122. 122.
    Trescot AM, Datta S, Lee M, Hansen H. Opioid pharmacology. Pain Physician. 2008;11(2 Suppl):S133–53.PubMedGoogle Scholar
  123. 123.
    National Institute on Drug Abuse. Commonly abused prescription drugs. Bethesda: National Institute on Drug Abuse; 2011.Google Scholar
  124. 124.
    Bart G. Maintenance medication for opiate addiction: the foundation of recovery. J Addict Dis. 2012;31(3):207–25.PubMedCentralPubMedGoogle Scholar
  125. 125.
    Center for Abuse Center for Substance Abuse Treatment. Medication assisted treatment for opioid addiction during pregnancy. ASHMSA/CSAT treatment improvement protocols. Rockville: Substance Abuse and Mental Health Services Administration (US); 2013.Google Scholar
  126. 126.
    Rothman JK. Causes. Am J Epidemiol. 1976;104:587–92.PubMedGoogle Scholar
  127. 127.
    Zierler S, Rothman KJ. Congenital heart disease in relation to maternal use of Bendectin and other drugs in early pregnancy. N Engl J Med. 1985;313(6):347–52.PubMedGoogle Scholar
  128. 128.
    Bracken MB. Drug use in pregnancy and congenital heart disease in offspring. N Engl J Med. 1986;314(17):1120.PubMedGoogle Scholar
  129. 129.
    Shaw GM, Malcoe LH, Swan SH, Cummins SK, Schulman J. Congenital cardiac anomalies relative to selected maternal exposures and conditions during early pregnancy. Eur J Epidemiol. 1992;8(5):757–60.PubMedGoogle Scholar
  130. 130.
    Broussard CS, Rasmussen SA, Reefhuis J, Friedman JM, Jann MW, Riehle-Colarusso T, et al. Maternal treatment with opioid analgesics and risk for birth defects. Am J Obstet Gynecol. 2011;204(4):314–11.PubMedGoogle Scholar
  131. 131.
    Kaltenbach K, Berghella V, Finnegan L. Opioid dependence during pregnancy. Effects and management. Obstet Gynecol Clin North Am. 1998;25(1):139–51.PubMedGoogle Scholar
  132. 132.
    Osborn DA, Jeffery HE, Cole MJ. Opiate treatment for opiate withdrawal in newborn infants. Cochrane Database Syst Rev. 2010;(10):CD002059.Google Scholar
  133. 133.
    Coghlan D, Milner M, Clarke T, Lambert I, McDermott C, McNally M, et al. Neonatal abstinence syndrome. Ir Med J. 1999;92(1):232–3. 236.PubMedGoogle Scholar
  134. 134.
    Johnson RE, Chutuape MA, Strain EC, Walsh SL, Stitzer ML, Bigelow GE. A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence. N Engl J Med. 2000;343(18):1290–7.PubMedGoogle Scholar
  135. 135.
    Drozdick III J, Berghella V, Hill M, Kaltenbach K. Methadone trough levels in pregnancy. Am J Obstet Gynecol. 2002;187(5):1184–8.PubMedGoogle Scholar
  136. 136.
    Kreek MJ. Medical safety and side effects of methadone in tolerant individuals. JAMA. 1973;223(6):665–8.PubMedGoogle Scholar
  137. 137.
    Strang J, Hall W, Hickman M, Bird SM. Impact of supervision of methadone consumption on deaths related to methadone overdose (1993-2008): analyses using OD4 index in England and Scotland. BMJ. 2010;341:c4851.PubMedCentralPubMedGoogle Scholar
  138. 138.
    Cornish R, Macleod J, Strang J, Vickerman P, Hickman M. Risk of death during and after opiate substitution treatment in primary care: prospective observational study in UK General Practice Research Database. BMJ. 2010;341:c5475.PubMedCentralPubMedGoogle Scholar
  139. 139.
    Bart G. CSAT’s QT, interval screening in methadone report: outrageous fortune or sea of troubles? J Addict Dis. 2011;30(4):313–7.PubMedCentralPubMedGoogle Scholar
  140. 140.
    Kaltenbach K, Finnegan LP. Perinatal and developmental outcome of infants exposed to methadone in-utero. Neurotoxicol Teratol. 1987;9(4):311–3.PubMedGoogle Scholar
  141. 141.
    Ling W, Casadonte P, Bigelow G, Kampman KM, Patkar A, Bailey GL, et al. Buprenorphine implants for treatment of opioid dependence: a randomized controlled trial. JAMA. 2010;304(14):1576–83.PubMedGoogle Scholar
  142. 142.
    Picard N, Cresteil T, Djebli N, Marquet P. In vitro metabolism study of buprenorphine: evidence for new metabolic pathways. Drug Metab Dispos. 2005;33(5):689–95.PubMedGoogle Scholar
  143. 143.
    Fudala PJ, Bridge TP, Herbert S, Williford WO, Chiang CN, Jones K, et al. Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. N Engl J Med. 2003;349(10):949–58.PubMedGoogle Scholar
  144. 144.
    Walsh SL, Preston KL, Stitzer ML, Cone EJ, Bigelow GE. Clinical pharmacology of buprenorphine: ceiling effects at high doses. Clin Pharmacol Ther. 1994;55(5):569–80.PubMedGoogle Scholar
  145. 145.
    Martin WR. Realistic goals for antagonist therapy. Am J Drug Alcohol Abuse. 1975;2(3–4):353–6.PubMedGoogle Scholar
  146. 146.
    Comer SD, Sullivan MA, Vosburg SK, Manubay J, Amass L, Cooper ZD, et al. Abuse liability of intravenous buprenorphine/naloxone and buprenorphine alone in buprenorphine-maintained intravenous heroin abusers. Addiction. 2010;105(4):709–18.PubMedCentralPubMedGoogle Scholar
  147. 147.
    Jasinski DR, Pevnick JS, Griffith JD. Human pharmacology and abuse potential of the analgesic buprenorphine: a potential agent for treating narcotic addiction. Arch Gen Psychiatry. 1978;35(4):501–16.PubMedGoogle Scholar
  148. 148.
    Reisinger M. Buprenorphine as new treatment for heroin dependence. Drug Alcohol Depend. 1985;16(3):257–62.PubMedGoogle Scholar
  149. 149.
    Tiong GK, Olley JE. Effects of exposure in utero to methadone and buprenorphine on enkephalin levels in the developing rat brain. Neurosci Lett. 1988;93(1):101–6.PubMedGoogle Scholar
  150. 150.
    van Baar A, de Graaff BM. Cognitive development at preschool-age of infants of drug-dependent mothers. Dev Med Child Neurol. 1994;36(12):1063–75.PubMedGoogle Scholar
  151. 151.
    van Baar AL, Soepatmi S, Gunning WB, Akkerhuis GW. Development after prenatal exposure to cocaine, heroin and methadone. Acta Paediatr Suppl. 1994;404:40–6.PubMedGoogle Scholar
  152. 152.
    Messinger DS, Bauer CR, Das A, Seifer R, Lester BM, Lagasse LL, et al. The maternal lifestyle study: cognitive, motor, and behavioral outcomes of cocaine-exposed and opiate-exposed infants through three years of age. Pediatrics. 2004;113(6):1677–85.PubMedGoogle Scholar
  153. 153.
    Abdel-Latif ME, Pinner J, Clews S, Cooke F, Lui K, Oei J. Effects of breast milk on the severity and outcome of neonatal abstinence syndrome among infants of drug-dependent mothers. Pediatrics. 2006;117(6):e1163–9.PubMedGoogle Scholar
  154. 154.
    Liu AJ, Nanan R. Methadone maintenance and breastfeeding in the neonatal period. Pediatrics. 2008;121(4):869–70.PubMedGoogle Scholar
  155. 155.
    Geraghty B, Graham EA, Logan B, Weiss EL. Methadone levels in breast milk. J Hum Lact. 1997;13(3):227–30.PubMedGoogle Scholar
  156. 156.
    Jones HE, Kaltenbach K, Heil SH, Stine SM, Coyle MG, Arria AM, et al. Neonatal abstinence syndrome after methadone or buprenorphine exposure. N Engl J Med. 2010;363(24):2320–31.PubMedCentralPubMedGoogle Scholar
  157. 157.
    Ebner N, Rohrmeister K, Winklbaur B, Baewert A, Jagsch R, Peternell A, et al. Management of neonatal abstinence syndrome in neonates born to opioid maintained women. Drug Alcohol Depend. 2007;87(2–3):131–8.PubMedGoogle Scholar
  158. 158.
    Hoflich AS, Langer M, Jagsch R, Bawert A, Winklbaur B, Fischer G, et al. Peripartum pain management in opioid dependent women. Eur J Pain. 2012;16(4):574–84.PubMedCentralPubMedGoogle Scholar
  159. 159.
    Jones HE, O’Grady K, Dahne J, Johnson R, Lemoine L, Milio L, et al. Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. Am J Drug Alcohol Abuse. 2009;35(3):151–6.PubMedCentralPubMedGoogle Scholar
  160. 160.
    Alford DP, Compton P, Samet JH. Acute pain management for patients receiving maintenance methadone or buprenorphine therapy. Ann Intern Med. 2006;144(2):127–34.PubMedCentralPubMedGoogle Scholar
  161. 161.
    Dryden C, Young D, Hepburn M, Mactier H. Maternal methadone use in pregnancy: factors associated with the development of neonatal abstinence syndrome and implications for healthcare resources. BJOG. 2009;116(5):665–71.PubMedGoogle Scholar
  162. 162.
    Muller-Vahl KR, Schneider U, Kolbe H, Emrich HM. Treatment of Tourette’s syndrome with delta-9-tetrahydrocannabinol. Am J Psychiatry. 1999;156(3):495.PubMedGoogle Scholar
  163. 163.
    Russo EB. Cannabis and cannabinoids: pharmacology, toxicology, and therapeutic potential. London: Routledge; 2002.Google Scholar
  164. 164.
    Mechoulam R, Gaoni Y. A total synthesis of DL-Delta-1-tetrahydrocannabinol, the active constituent of hashish. J Am Chem Soc. 1965;87:3273–5.PubMedGoogle Scholar
  165. 165.
    Kathmann M, Flau K, Redmer A, Trankle C, Schlicker E. Cannabidiol is an allosteric modulator at mu- and delta-opioid receptors. Naunyn Schmiedebergs Arch Pharmacol. 2006;372(5):354–61.PubMedGoogle Scholar
  166. 166.
    Hejazi N, Zhou C, Oz M, Sun H, Ye JH, Zhang L. Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol. 2006;69(3):991–7.PubMedGoogle Scholar
  167. 167.
    Huizink AC, Ferdinand RF, Ormel J, Verhulst FC. Hypothalamic-pituitary-adrenal axis activity and early onset of cannabis use. Addiction. 2006;101(11):1581–8.PubMedGoogle Scholar
  168. 168.
    El MH, Tiemeier H, Steegers EA, Jaddoe VW, Hofman A, Verhulst FC, et al. Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study. J Am Acad Child Adolesc Psychiatry. 2009;48(12):1173–81.Google Scholar
  169. 169.
    de Moraes Barros MC, Guinsburg R, de Araujo PC, Mitsuhiro S, Chalem E, Laranjeira RR. Exposure to marijuana during pregnancy alters neurobehavior in the early neonatal period. J Pediatr. 2006;149(6):781–7.PubMedGoogle Scholar
  170. 170.
    Huizink AC. Prenatal cannabis exposure and infant outcomes: overview of studies. Prog Neuropsychopharmacol Biol Psychiatry. 2014;52:45–52.PubMedGoogle Scholar
  171. 171.
    Fried PA. Marihuana use by pregnant women: neurobehavioral effects in neonates. Drug Alcohol Depend. 1980;6(6):415–24.PubMedGoogle Scholar
  172. 172.
    Richardson GA, Day NL, Taylor PM. Effect of prenatal alcohol, marijuana, and tobacco exposure on neonatal behavior. Infant Behav Dev. 1989;12(2):199–209.Google Scholar
  173. 173.
    Smith AM, Fried PA, Hogan MJ, Cameron I. Effects of prenatal marijuana on visuospatial working memory: an fMRI study in young adults. Neurotoxicol Teratol. 2006;28(2):286–95.PubMedGoogle Scholar
  174. 174.
    Richardson GA, Day NL, Goldschmidt L. Prenatal alcohol, marijuana, and tobacco use: infant mental and motor development. Neurotoxicol Teratol. 1995;17(4):479–87.PubMedGoogle Scholar
  175. 175.
    Fernandez JR, Allison DB. Rimonabant Sanofi-Synthelabo. Curr Opin Investig Drugs. 2004;5(4):430–5.PubMedGoogle Scholar
  176. 176.
    Clapper JR, Mangieri RA, Piomelli D. The endocannabinoid system as a target for the treatment of cannabis dependence. Neuropharmacology. 2009;56 Suppl 1:235–43.PubMedCentralPubMedGoogle Scholar
  177. 177.
    Budney AJ, Hughes JR, Moore BA, Vandrey R. Review of the validity and significance of cannabis withdrawal syndrome. Am J Psychiatry. 2004;161(11):1967–77.PubMedGoogle Scholar
  178. 178.
    Budney AJ, Moore BA, Sigmon SC, Higgins ST. Contingency-management interventions for cannabis dependence, in cannabis dependence; its nature, consequences, and treatment. In: Roffman RA, Stephens RS, editors. Cannabis dependence; its nature, consequences, and treatment. New York: Cambridge; 2006. p. 155–79.Google Scholar
  179. 179.
    Haney M, Hart CL, Vosburg SK, Nasser J, Bennett A, Zubaran C, et al. Marijuana withdrawal in humans: effects of oral THC or divalproex. Neuropsychopharmacology. 2004;29(1):158–70.PubMedGoogle Scholar
  180. 180.
    Hannigan JH, Bowen SE. Reproductive toxicology and teratology of abused toluene. Syst Biol Reprod Med. 2010;56(2):184–200.PubMedGoogle Scholar
  181. 181.
    Jones HE, Balster RL. Inhalant abuse in pregnancy. Obstet Gynecol Clin North Am. 1998;25(1):153–67.PubMedGoogle Scholar
  182. 182.
    Medina-Mora ME, Real T. Epidemiology of inhalant use. Curr Opin Psychiatry. 2008;21(3):247–51.PubMedGoogle Scholar
  183. 183.
    Pearson MA, Hoyme HE, Seaver LH, Rimsza ME. Toluene embryopathy: delineation of the phenotype and comparison with fetal alcohol syndrome. Pediatrics. 1994;93(2):211–5.PubMedGoogle Scholar
  184. 184.
    Williams JF, Storck M. Inhalant abuse. Pediatrics. 2007;119(5):1009–17.PubMedGoogle Scholar
  185. 185.
    Howard MO, Bowen SE, Garland EL, Perron BE, Vaughn MG. Inhalant use and inhalant use disorders in the United States. Addict Sci Clin Pract. 2011;6(1):18–31.PubMedCentralPubMedGoogle Scholar
  186. 186.
    Garland EL, Howard MO. Volatile substance misuse: clinical considerations, neuropsychopharmacology and potential role of pharmacotherapy in management. CNS Drugs. 2012;26(11):927–35.PubMedGoogle Scholar
  187. 187.
    Bowen SE, Daniel J, Balster RL. Deaths associated with inhalant abuse in Virginia from 1987 to 1996. Drug Alcohol Depend. 1999;53(3):239–45.PubMedGoogle Scholar
  188. 188.
    Gautschi OP, Cadosch D, Zellweger R. Postural tremor induced by paint sniffing. Neurol India. 2007;55(4):393–5.PubMedGoogle Scholar
  189. 189.
    Hall MT, Edwards JD, Howard MO. Accidental deaths due to inhalant misuse in North Carolina: 2000-2008. Subst Use Misuse. 2010;45(9):1330–9.PubMedGoogle Scholar
  190. 190.
    Arnold GL, Kirby RS, Langendoerfer S, Wilkins-Haug L. Toluene embryopathy: clinical delineation and developmental follow-up. Pediatrics. 1994;93(2):216–20.PubMedGoogle Scholar
  191. 191.
    Wilkins-Haug L, Gabow PA. Toluene abuse during pregnancy: obstetric complications and perinatal outcomes. Obstet Gynecol. 1991;77(4):504–9.PubMedGoogle Scholar
  192. 192.
    Cordier S, Ha MC, Ayme S, Goujard J. Maternal occupational exposure and congenital malformations. Scand J Work Environ Health. 1992;18(1):11–7.PubMedGoogle Scholar
  193. 193.
    Bowen SE, Hannigan JH. Developmental toxicity of prenatal exposure to toluene. AAPS J. 2006;8(2):E419–24.PubMedCentralPubMedGoogle Scholar
  194. 194.
    Beauvais F, Jumper-Thurman P, Plested B, Helm H. A survey of attitudes among drug user treatment providers toward the treatment of inhalant users. Subst Use Misuse. 2002;37(11):1391–410.PubMedGoogle Scholar
  195. 195.
    Sakai JT, Mikulich-Gilbertson SK, Crowley TJ. Adolescent inhalant use among male patients in treatment for substance and behavior problems: two-year outcome. Am J Drug Alcohol Abuse. 2006;32(1):29–40.PubMedGoogle Scholar
  196. 196.
    Shen YC. Treatment of inhalant dependence with lamotrigine. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(3):769–71.PubMedGoogle Scholar
  197. 197.
    Erdogan A, Yurteri N. Aripiprazole treatment in the adolescent patients with inhalants use disorders and conduct disorder: a retrospective case analysis. Yeni Symposium. eni Symposium; 2010. p. 229–33.Google Scholar
  198. 198.
    Muralidharan K, Rajkumar RP, Mulla U, Nayak RB, Benegal V. Baclofen in the management of inhalant withdrawal: a case series. Prim Care Companion J Clin Psychiatry. 2008;10(1):48–51.PubMedCentralPubMedGoogle Scholar
  199. 199.
    Westermeyer J. The psychiatrist and solvent-inhalant abuse: recognition, assessment, and treatment. Am J Psychiatry. 1987;144(7):903–7.PubMedGoogle Scholar
  200. 200.
    Tenenbein M, Casiro OG, Seshia MM, Debooy VD. Neonatal withdrawal from maternal volatile substance abuse. Arch Dis Child Fetal Neonatal Ed. 1996;74(3):F204–7.PubMedCentralPubMedGoogle Scholar
  201. 201.
    Lee DE, Schiffer WK, Dewey SL. Gamma-vinyl GABA (vigabatrin) blocks the expression of toluene-induced conditioned place preference (CPP). Synapse. 2004;54(3):183–5.PubMedGoogle Scholar
  202. 202.
    Goldstein RZ, Woicik PA, Maloney T, Tomasi D, ia-Klein N, Shan J, et al. Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task. Proc Natl Acad Sci USA. 2010;107(38):16667–72.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Gulshan Doulatram
    • 1
  • Tilak D. Raj
    • 2
  • Ranganathan Govindaraj
    • 1
  1. 1.Department of AnesthesiologyUniversity of Texas Medical BranchGalvestonUSA
  2. 2.Department of AnesthesiologyOklahoma University Health Sciences Center/OU Medical CenterOklahoma CityUSA

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