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Studies on the Cornea and Lens pp 317–326Cite as

The Effects of Lutein in Preventing Cataract Progression

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Abstract

Oxidation is a major cause of cataract formation and antioxidants are presumed to be effective in preventing cataracts. Among the antioxidant nutrients, lutein is noteworthy for reducing the risk of cataract formation. The effects of lutein were verified by measuring changes in mRNA expression in order to represent the synthesis of certain proteins as mRNA transcription initiates the first stage of protein synthesis. One of our studies investigated mRNA expression of antioxidative enzymes in the lenticular anterior capsules of the same patients before and after intaking the antioxidant supplement. After intaking, the expression of glucose-6-phosphate dehydrogenase (G6PDH) and 18S rRNA (18S) increased significantly. There were also significant positive correlations between G6PDH and 18S expression. G6PDH expression quadrupled and 18S expression almost doubled. This strongly suggests the antioxidative effect of lutein in the lens and that it may be effective in preventing the progression of cataract formation.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Koshigaya Hospital, Dokkyo Medical University, Koshigaya, Saitama, Japan

    Rijo Hayashi

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  1. Rijo Hayashi
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Correspondence to Rijo Hayashi .

Editor information

Editors and Affiliations

  1. Innovative Vision Products Inc., Moscow, Russia, Innovative Vision Products, Inc.,, County of New Castle, Delaware, USA

    Mark A. Babizhayev

  2. Department of Ophthalmology and Visual Sciences, Truhlsen Eye Institute, College of Medicine, University of Nebraska Medical Center; Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China, Omaha, Nebraska, USA

    David Wan-Cheng Li

  3. Department of Pharmaceutical Sciences and Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA

    Anne Kasus-Jacobi

  4. Department of Ophthalmology, University of Pristina, Faculty of Medicine, Kosovska Mitrovica, Serbia

    Lepša Žorić

  5. Ophthalmology, Miguel Hernandez University, Alicante, Spain

    Jorge L. Alió

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Hayashi, R. (2015). The Effects of Lutein in Preventing Cataract Progression. In: Babizhayev, M., Li, DC., Kasus-Jacobi, A., Žorić, L., Alió, J. (eds) Studies on the Cornea and Lens. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1935-2_17

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