Abstract
The human lens is essential for vision, but also a living biometric indicator of health. The environment, a myriad number of ocular and systemic diseases and aging itself, often simultaneously impact upon the health of this living tissue. Yet with few exceptions, twenty first century eye doctors ignore the individual and public health importance of the human lens by describing its state with simple qualitative nomenclature, handwritten drawings, and disposing of this tissue upon cataract extraction. Because the lens maintains intimate associations with health, vision, successful aging, and even individual life expectancy, the authors review in office high tech lens monitoring instruments that can positively impact both individuals and societies. New handheld low tech and high tech cataract monitoring technology enables individualized assessment of progressive incremental lifestyle changes that impact on his/her lens health and mortality. The lens is also useful for identifying our most vulnerable patients—those with the lowest intake of nutrients where broad-spectrum multivitamin/mineral supplementation has shown the greatest efficacy.
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References
Duncan G. The aging human lens: structure, growth, and physiological behaviour. Br J Ophthalmol. 1997;81(10):818–23. http://bjo.bmj.com/content/81/10/818.full.
Brown N. The change in shape and internal form of the lens of the eye on accommodation. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pubmed/4702379
Optometric Clinical Practice Guideline. Care of the adult patient with presbyopia. American Optometric Association. http://www.aoa.org/documents/CPG-17.pdf
Stafford MJ. The histology and biology of the lens. Association of Optometrists—London. 2001. http://www.optometry.co.uk/uploads/articles/0b3e55d71662f4e8381aea8637c48f4f_stafford20010112.pdf
Optometric Clinical Practice Guideline. Care of the adult patient with cataract. American Optometric Association. http://www.aoa.org/documents/CPG-8.pdf
Benedek GB. Cataract as a protein condensation disease. Association for Research in Vision and Ophthalmology. http://www.iovs.org/content/38/10/1911.full.pdf
Facts about cataract. National Eye Institute Health Information. http://www.nei.nih.gov/health/cataract/cataract_facts.asp#1a
Richer, et al. Etiology of non-congenital non-age related cataract. Optometry. 2001;72:767–78.
Svobodová AR, Galandáková A, Sianská J, Doležal D, Lichnovská R, Ulrichová J, Vostálová J. DNA damage after acute exposure of mice skin to physiological doses of UVB and UVA Light. National Center for Biotechnology Information. U.S. National Library of Medicine, July 2012. https://www.ncbi.nlm.nih.gov/pubmed/22271212
Mohan M, Sperduto RD, Angra SK, Milton RC, Mathur RL. India-US case-control study of age-related cataracts. India-US Case-Control Study Group. National Center for Biotechnology Information. U.S. National Library of Medicine, May 1989. Web. 2013. http://www.ncbi.nlm.nih.gov/pubmed/2818712
Hodge WG, Whitcher JP, Satariano W. Risk factors for age-related cataracts. National Center for Biotechnology Information. U.S. National Library of Medicine. Epidemiol Rev. 1995;17(2):336–46. http://www.ncbi.nlm.nih.gov/pubmed/8654515
Cruickshanks KJ, Klein BE, Klein R. Ultraviolet light exposure and lens opacities: The Beaver Dam Eye Study. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1694542
Taylor HR. Ultraviolet light and the eye: an epidemiologic study. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298564/pdf/taos00012-0827.pdf
Anekonda TS. The benefits of calorie restriction and calorie restriction mimetics as related to the eye. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939013
Wang K, Li D, Sun F. Dietary caloric restriction may delay the development of cataract by attenuating the oxidative stress in the lenses of brown Norway rats. National Center for Biotechnology Information. U.S. National Library of Medicine. Jan–Feb 2004. http://www.ncbi.nlm.nih.gov/pubmed/14667836
Chiu C-J, Milton RC, Gensler G, Taylor A. Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities. The American Journal of Clinical Nutrition. http://ajcn.nutrition.org/content/81/6/1411.full
Obrosova IG, Chung SSM, Kador PF. Diabetic cataracts: mechanisms and management. National Center for Biotechnology Information. U.S. National Library of Medicine. Diabetes Metab Res Rev. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20474067
Rahman K. Studies on free radicals, antioxidants, and co-factors. National Center for Biotechnology Information. U.S. National Library of Medicine. 2005. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684512
Grahn BH, Paterson PG, Gottschall-Pass KT, Zhang Z. Zinc and the eye. National Center for Biotechnology Information. U.S. National Library of Medicine. 2001. http://www.ncbi.nlm.nih.gov/pubmed/11349933
Cataracts as an outcome of zinc deficiency in salmon. Nutr Rev. 1986;44(3):118–20.
Watts DL. The nutritional relationships of selenium. J Orthomol Med. 1994;9(2):111–7. http://orthomolecular.org/library/jom/1994/articles/1994-v09n02-p111.shtml.
Handa JT. How does the macula protect itself from oxidative stress? Mol Aspects Med. 2012;33(4):418–35.
Blundell M, Hunt L, Mayer E, Dick A, Sparrow J. Ophthalmol Scand. 1999;77(1):99–102.
Bek T. Ocular changes in heredo-oto-ophthalmo-encephalopathy. Br J Ophthalmol. 2000;84:1298–302.
Lutein & zeaxanthin. American Optometric Association. http://www.aoa.org/patients-and-public/caring-for-your-vision/diet-and-nutrition/lutein
Painter FM. Lutein and zeaxanthin. Alternat Med Rev. 2005;10(2):128–35. Thorne Research, Inc. http://www.thorne.com/altmedrev/.fulltext/10/2/128.pdf.
Cumming RG, Mitchell P. Alcohol, smoking, and cataracts: the Blue Mountains Eye Study. National Center for Biotechnology Information. U.S. National Library of Medicine. 1997. http://www.ncbi.nlm.nih.gov/pubmed/9338677
Kanthan GL, Mitchell P, Burlutsky G, Wang JJ. Alcohol consumption and the long-term incidence of cataract and cataract curgery: The Blue Mountains Eye Study. National Center for Biotechnology Information. U.S. National Library of Medicine. 2010. http://www.ncbi.nlm.nih.gov/pubmed/20619390
Ye J, He J, Wang C, Wu H. Smoking and risk of age-related cataract: a meta-analysis. National Center for Biotechnology Information. U.S. National Library of Medicine. 2012. http://www.ncbi.nlm.nih.gov/pubmed/22599585
Tan JS, Wang JJ, Mitchell P. Influence of diabetes and cardiovascular disease on the long-term incidence of cataract: The Blue Mountains Eye Study. National Center for Biotechnology Information. U.S. National Library of Medicine. 2008. http://www.ncbi.nlm.nih.gov/pubmed/18850468
Hu FB, Hankinson SE, Stampfer MJ, Manson JE, Colditz GA, Speizer FE, Hennekens CH. Prospective study of cataract extraction and risk of coronary heart disease in women. National Center for Biotechnology Information. U.S. National Library of Medicine. 2001. http://www.ncbi.nlm.nih.gov/pubmed/11323318
Fong CS, Mitchell P, Rochtchina E, Teber T, Hong T. Ophthalmology. 2009;93(3):290–5.
Sakata L, Sakata K, Malta RF. Cataract surgery and glaucoma. Ophthalmology. 2007;114(1):195–6.
Knudsen E, Baggesen K, Naeser K. Graefes Arch Clin Exp Ophthalmol. 2008;246(4):615–7.
Tabin G, Chen M, Espandar L. Cataract surgery for the developing world. Curr Opin Ophthalmol. 2008;19:55–9.
Catharine Ross A, Taylor CL, Yaktine AL, Del Valle HB, editors. Institute of Medicine (US) Committee to review dietary reference intakes for vitamin D and calcium. Washington, DC: National Academies Press; 2011.
Nemet AY, Hanhart J, Kaiserman I, Vinker S. Are cataracts associated with osteoporosis? Clin Ophthalmol. 2013;7:2079–84.
Tang D. Influence of age, diabetes, and cataract on calcium, lipid-calcium, and protein-calcium relationships in human lenses. Invest Ophthalmol Vis Sci. 2003;44(5):2059–66.
Vanessa Caceres: Eye world contributing author, April 2014. Post-menopausal hormone use: a protective effect against cataracts?
Holt PR, Russel RM. Chronic castritis and hypochlorhydria in the elderly. New York: CRC Press; 1993.
Sheen E, Triadafilopoulos G. Adverse effects of long-term proton pump inhibitor therapy. National Center for Biotechnology Information. U.S. National Library of Medicine. 2011. http://www.ncbi.nlm.nih.gov/pubmed/21365243
Christen WG, et al. Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pubmed/22503302
Packer L, Colman C. The antioxidant miracle: put lipoic acid, pycnogenol, and vitamins E and C to work for you. ISBN 13: 9780471353119.
Office of Dietary Supplements (ODS), National Institute of Health. http://ods.od.nih.gov/
Sesso HD, Buring JE, Christen WG. Vitamins E and C in the prevention of cardiovascular disease in men: the physicians’ health study II randomized trial. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586922/
Rautiainen S, Lindblad B, Morgenstern R. Vitamin C supplements and the risk of age-related cataract: a population-based prospective cohort study in women. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pubmed/23420353
Gritz D, Srinivasan M. Antioxidants for prevention of cataracts follow-up study. http://clinicaltrials.gov/show/NCT01664819
Packer L, Colman C. The antioxidant miracle. A brief review by Ivy Greenwell. Life Extension Magazine. 1999.
Wu G, Fang YZ. Glutathione metabolism and its implications for health. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pubmed/14988435
Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. National Center for Biotechnology Information. U.S. National Library of Medicine. 2006. http://www.ncbi.nlm.nih.gov/pubmed/11302779
Noctor G, Foyer CH. Ascorbate and glutathione: keeping active oxygen under control. National Center for Biotechnology Information. U.S. National Library of Medicine. http://www.ncbi.nlm.nih.gov/pubmed/15012235
Currie Z, Bhan A, Pepper I. Reliability of Snellen charts for testing visual acuity for driving: prospective study and postal questionnaire. Br Med J. 2000;321:990–2. http://www.bmj.com/content/321/7267/990.
Kaiser PK. Prospective evaluation of visual acuity assessment: a comparison of Snellen versus ETDRS charts in clinical practice. Am Ophthalmol Soc. 2009;107:311–24. US National Library of Medicine National Institutes of Health Search Term-Search Database. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814576/?report=classic.
Mainster MA, Turner PL. Glare’s causes, consequences, and clinical challenges after a century of ophthalmic study. Am J Ophthalmol. 2012;153(4):587–93. http://www.ajo.com/article/S0002-9394(12)00041-4/abstract.
The Optec® Functional Vision Analyzer™—contrast sensitivity tests with two glare levels under four testing conditions. http://www.stereooptical.com/products/vision-testers/functional-vision-analyzer
Optometric Clinical Practice Guideline. Care of the patient with visual impairment (low vision rehabilitation). American Optometric Association. http://www.aoa.org/documents/CPG-17.pdf
GALILEI™ Dual Scheimpflug Analyzer from Ziemer Group. http://www.ophthalmologyweb.com/5599-Computerized-Corneal-Analysis-Systems/53052-GALILEI-Dual-Scheimpflug-Analyzer/
iTRACE™ Combination Ray Tracing Aberrometer/Topographer. http://www.traceytechnologies.com/products_iTrace.htm
All Features: Pentacam™, the Gold Standard in Anterior Segment Tomography. http://www.pentacam.com/sites/hr_features.php
Belin MW. The Pentacam: precision, confidence, results, and accurate “Ks!”. Cataract & Refractive Surgery Today. 2007. http://www.pentacam.com/downloads/studien/pentacam_aao_2006.pdf
Belin MW. Other clinical uses of the Pentacam: cataract, glaucoma, cornea. Applications of the Oculus Pentacam. http://oculus.cnpg.com/video/flatfiles/1342/
Datiles III MB, Ansari RR, Suh KI, et al. Clinical detection of precataractous lens protein changes using dynamic light scattering. Arch Ophthalmol. 2008;126(12):1687–93. archophthalmol.2008.507. http://archopht.jamanetwork.com/article.aspx?articleid=420932.
Ansari RR, Datiles MB III, King JF. A new clinical instrument for the early detection of cataract using dynamic light scattering and corneal topography. Optikon Men and Technology. NASA/CR—2000-209955. http://www.optikon.com/en/show-article.asp?section=archive&articleID=114
Ansari RR, King JF, Giblin FJ. Applications in bioastronautics and bioinformatics: early radiation cataracts detected by noninvasive, quantitative, and remote means. National Center for Microgravity Research. http://www.grc.nasa.gov/WWW/RT/RT2000/6000/6712ansari.html
Pamplona VF, Passos EB, Zizka J. CATRA: CATRA: interactive measuring and modeling of cataracts. Cataract maps with snap-on eyepiece for mobile phones. MIT Media Lab—CATRA. 2012. http://web.media.mit.edu/~pamplona/CATRA/
Cheung CY. Validity of a new computer-aided diagnosis imaging program to quantify nuclear cataract from slit-lamp photographs. National Center for Biotechnology Information. U.S. National Library of Medicine. 2011. http://www.ncbi.nlm.nih.gov/pubmed/21051727
Li H. A computer-aided diagnosis system of nuclear cataract. IEEE Xplore. 2010. http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=5415679
Cahn F. Measurement of lens autofluorescence can distinguish subjects with diabetes from those without. J Diabetes Sci Technol. 2014;8:43–9.
Bone RA, Mukherjee A. Innovative Troxler-free measurement of macular pigment and lens density with correction of the former for the aging lens. J Biomed Opt. 2013;18(10):107003. http://www.ncbi.nlm.nih.gov/pubmed/24114020.
Acknowledgement
This chapter is based on original clinical work supported by the Optometry/Ophthalmology sections of Captain James A Lovell Federal Health Care Facility, DVA-Naval Medical Center, North Chicago, IL, USA.
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Richer, S. et al. (2015). The Human Lens: A Living Biometric Indicator of Health Status and Successful Aging. In: Babizhayev, M., Li, DC., Kasus-Jacobi, A., Žorić, L., Alió, J. (eds) Studies on the Cornea and Lens. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1935-2_10
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