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Stem Cell-Based Therapies for Spinal Cord Regeneration

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Neural Stem Cells in Development, Adulthood and Disease

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Complete spinal cord injury, characterized by complete loss of motor, sensory, and autonomous function below the level of injury, requires robust therapeutic approaches to replace damaged neural tissue, including astroglia, oligodendroglia, and neurons. Defined stem and progenitor cell populations, from virtually any developmental stage, can differentiate into glia and neurons, thereby having the capacity to replace degenerated spinal cord tissue in a phenotypically appropriate fashion. Numerous preclinical in vivo studies in various spinal cord injury models have demonstrated that stem cell transplantation strategies can indeed promote morphological, and in some cases functional, recovery, via different mechanisms, including remyelination, axonal growth, and regeneration or neuronal replacement. To date, two neural stem cell-based transplantation strategies have moved to phase I clinical trials. This review provides an overview on the current status of neural stem cell transplantation in spinal cord injury and discusses future perspectives in the field.

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Acknowledgments

This work was supported by Wings for Life, Spinal Cord Research Foundation (to B.S.), the International Foundation for Research in Paraplegia (P119 to A.B. and N.W.) and the EU (IRG268282 to A.B.).

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Authors and Affiliations

  1. Spinal Cord Injury Center, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69121, Heidelberg, Germany

    Beatrice Sandner, Peter Prang, Armin Blesch & Norbert Weidner M.D.

  2. Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA

    Armin Blesch

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  1. Beatrice Sandner
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  2. Peter Prang
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  4. Norbert Weidner M.D.
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Correspondence to Norbert Weidner M.D. .

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  1. Institute for Neuroscience & Physiology University of Gothenburg, Gothenburg, Sweden

    H. Georg Kuhn

  2. Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA

    Amelia J. Eisch

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Sandner, B., Prang, P., Blesch, A., Weidner, N. (2015). Stem Cell-Based Therapies for Spinal Cord Regeneration. In: Kuhn, H., Eisch, A. (eds) Neural Stem Cells in Development, Adulthood and Disease. Stem Cell Biology and Regenerative Medicine. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1908-6_9

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