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Abstract

The vast majority of prostate imaging is for the localization, characterization, and staging of cancer, making it the focus of this chapter. Ultrasound, MRI, CT, and radionuclide studies may be used in the diagnosis, staging, and posttreatment monitoring of prostate cancer. Each serves a unique function depending on the predicted aggressiveness of disease. In addition, we will review nonmalignant disorders of the prostate, of which imaging plays a limited role.

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References

  1. Skanjeti A, Pelosi E. Lymph node staging with choline PET/CT in patients with prostate cancer: a review. ISRN Oncol. 2011;2011:219064.

    PubMed  PubMed Central  Google Scholar 

  2. Nghiem HT, Kellman GM, Sandberg SA, Craig BM. Cystic lesions of the prostate. Radiographics. 1990;10(4):635–50.

    Article  CAS  PubMed  Google Scholar 

  3. Phillips ME, Kressel HY, Spritzer CE, et al. Normal prostate and adjacent structures: MR imaging at 1.5 T. Radiology. 1987;164(2):381–5.

    Article  CAS  PubMed  Google Scholar 

  4. Kundra V, Silverman PM, Matin SF, Choi H. Imaging in oncology from the university of Texas M. D. anderson cancer center: diagnosis, staging, and surveillance of prostate cancer. AJR Am J Roentgenol. 2007;189(4):830–44.

    Article  PubMed  Google Scholar 

  5. Vargas HA, Akin O, Franiel T, et al. Normal central zone of the prostate and central zone involvement by prostate cancer: clinical and MR imaging implications. Radiology. 2012;262(3):894–902.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Eberhardt SC, Carter S, Casalino DD, et al. ACR appropriateness criteria prostate cancer–pretreatment detection, staging, and surveillance. J Am Coll Radiol. 2013;10(2):83–92.

    Article  PubMed  Google Scholar 

  7. Casalino DD, Remer EM, Arellano RS, et al. ACR appropriateness criteria(R) posttreatment follow-up of prostate cancer. J Am Coll Radiol. 2011;8(12):863–71.

    Article  PubMed  Google Scholar 

  8. Rifkin MD, Zerhouni EA, Gatsonis CA, et al. Comparison of magnetic resonance imaging and ultrasonography in staging early prostate cancer. Results of a multi-institutional cooperative trial. N Engl J Med. 1990;323(10):621–6.

    Article  CAS  PubMed  Google Scholar 

  9. Hamper UM, Sheth S, Walsh PC, Holtz PM, Epstein JI. Carcinoma of the prostate: value of transrectal sonography in detecting extension into the neurovascular bundle. AJR Am J Roentgenol. 1990;155(5):1015–9.

    Article  CAS  PubMed  Google Scholar 

  10. Hamper UM, Sheth S, Walsh PC, Holtz PM, Epstein JI. Capsular transgression of prostatic carcinoma: evaluation with transrectal US with pathologic correlation. Radiology. 1991;178(3):791–5.

    Article  CAS  PubMed  Google Scholar 

  11. Dahnert WF, Hamper UM, Eggleston JC, Walsh PC, Sanders RC. Prostatic evaluation by transrectal sonography with histopathologic correlation: the echopenic appearance of early carcinoma. Radiology. 1986;158(1):97–102.

    Article  CAS  PubMed  Google Scholar 

  12. Cornud F, Hamida K, Flam T, et al. Endorectal color Doppler sonography and endorectal MR imaging features of nonpalpable prostate cancer: correlation with radical prostatectomy findings. AJR Am J Roentgenol. 2000;175(4):1161–8.

    Article  CAS  PubMed  Google Scholar 

  13. Sedelaar JP, van Leenders GJ, Goossen TE, et al. Value of contrast ultrasonography in the detection of significant prostate cancer: correlation with radical prostatectomy specimens. Prostate. 2002;53(3):246–53.

    Article  CAS  PubMed  Google Scholar 

  14. Sauvain JL, Palascak P, Bourscheid D, et al. Value of power doppler and 3D vascular sonography as a method for diagnosis and staging of prostate cancer. Eur Urol. 2003;44(1):21–30; discussion 30–1.

    Article  CAS  PubMed  Google Scholar 

  15. Stilmant MM, Kuligowska E. Transrectal ultrasound screening for prostatic adenocarcinoma with histopathological correlation. Factors affecting specificity. Cancer. 1993;71(6):2041–7.

    Article  CAS  PubMed  Google Scholar 

  16. Frauscher F, Gradl J, Pallwein L. Prostate ultrasound – for urologists only? Cancer Imaging. 2005;5(Spec No A):S76–82.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Ozden E, Gogus C, Kilic O, Yaman O, Ozdiler E. Analysis of suprapubic and transrectal measurements in assessment of prostate dimensions and volume: is transrectal ultrasonography really necessary for prostate measurements? Urol J. 2009;6(3):208–13.

    PubMed  Google Scholar 

  18. Hricak H, Choyke PL, Eberhardt SC, Leibel SA, Scardino PT. Imaging prostate cancer: a multidisciplinary perspective. Radiology. 2007;243(1):28–53.

    Article  PubMed  Google Scholar 

  19. Albertsen PC, Hanley JA, Harlan LC, et al. The positive yield of imaging studies in the evaluation of men with newly diagnosed prostate cancer: a population based analysis. J Urol. 2000;163(4):1138–43.

    Article  CAS  PubMed  Google Scholar 

  20. Platt JF, Bree RL, Schwab RE. The accuracy of CT in the staging of carcinoma of the prostate. AJR Am J Roentgenol. 1987;149(2):315–8.

    Article  CAS  PubMed  Google Scholar 

  21. Kramer S, Gorich J, Gottfried HW, et al. Sensitivity of computed tomography in detecting local recurrence of prostatic carcinoma following radical prostatectomy. Br J Radiol. 1997;70(838):995–9.

    Article  CAS  PubMed  Google Scholar 

  22. Lutje S, Boerman OC, van Rij CM, et al. Prospects in radionuclide imaging of prostate cancer. Prostate. 2012;72(11):1262–72.

    Article  PubMed  Google Scholar 

  23. Sukov RJ, Scardino PT, Sample WF, Winter J, Confer DJ. Computed tomography and transabdominal ultrasound in the evaluation of the prostate. J Comput Assist Tomogr. 1977;1(3):281–9.

    Article  CAS  PubMed  Google Scholar 

  24. Barentsz JO, Richenberg J, Clements R, et al. ESUR prostate MR guidelines 2012. Eur Radiol. 2012;22(4):746–57.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Futterer JJ, Scheenen TW, Huisman HJ, et al. Initial experience of 3 tesla endorectal coil magnetic resonance imaging and 1H-spectroscopic imaging of the prostate. Invest Radiol. 2004;39(11):671–80.

    Article  PubMed  Google Scholar 

  26. Futterer JJ, Heijmink SW, Scheenen TW, et al. Prostate cancer: local staging at 3-T endorectal MR imaging–early experience. Radiology. 2006;238(1):184–91.

    Article  PubMed  Google Scholar 

  27. Cher ML, Bianco Jr FJ, Lam JS, et al. Limited role of radionuclide bone scintigraphy in patients with prostate specific antigen elevations after radical prostatectomy. J Urol. 1998;160(4):1387–91.

    Article  CAS  PubMed  Google Scholar 

  28. Tateishi U, Morita S, Taguri M, et al. A meta-analysis of (18)F-fluoride positron emission tomography for assessment of metastatic bone tumor. Ann Nucl Med. 2010;24(7):523–31.

    Article  PubMed  Google Scholar 

  29. Volmar KE, Fritsch MK, Perlman EJ, Hutchins GM. Patterns of congenital lower urinary tract obstructive uropathy: relation to abnormal prostate and bladder development and the prune belly syndrome. Pediatr Dev Pathol. 2001;4(5):467–72.

    Article  CAS  PubMed  Google Scholar 

  30. Schnall MD, Lenkinski RE FAU, Lenkinski RE, et al. Prostate: MR imaging with an endorectal surface coil. Radiology. 1989;172(2):570–4. 0033-8419 (Print); 0033-8419 (Linking).

    Article  CAS  PubMed  Google Scholar 

  31. McDermott VG, Meakem 3rd TJ, Stolpen AH, Schnall MD. Prostatic and periprostatic cysts: findings on MR imaging. AJR Am J Roentgenol. 1995;164(1):123–7.

    Article  CAS  PubMed  Google Scholar 

  32. Grossfeld GD, Coakley FV. Benign prostatic hyperplasia: clinical overview and value of diagnostic imaging. Radiol Clin North Am. 2000;38(1):31–47.

    Article  CAS  PubMed  Google Scholar 

  33. Guess HA, Arrighi HM, Metter EJ, Fozard JL. Cumulative prevalence of prostatism matches the autopsy prevalence of benign prostatic hyperplasia. Prostate. 1990;17(3):241–6.

    Article  CAS  PubMed  Google Scholar 

  34. Nickel JC, Downey J, Hunter D, Clark J. Prevalence of prostatitis-like symptoms in a population based study using the national institutes of health chronic prostatitis symptom index. J Urol. 2001;165(3):842–5.

    Article  CAS  PubMed  Google Scholar 

  35. Millan-Rodriguez F, Palou J, Bujons-Tur A, et al. Acute bacterial prostatitis: two different sub-categories according to a previous manipulation of the lower urinary tract. World J Urol. 2006;24(1):45–50.

    Article  PubMed  Google Scholar 

  36. Chia JK, Longfield RN, Cook DH, Flax BL. Computed axial tomography in the early diagnosis of prostatic abscess. Am J Med. 1986;81(5):942–4.

    Article  CAS  PubMed  Google Scholar 

  37. Doble A, Carter SS. Ultrasonographic findings in prostatitis. Urol Clin North Am. 1989;16(4):763–72.

    CAS  PubMed  Google Scholar 

  38. Shukla-Dave A, Hricak H, Eberhardt SC, et al. Chronic prostatitis: MR imaging and 1H MR spectroscopic imaging findings–initial observations. Radiology. 2004;231(3):717–24.

    Article  PubMed  Google Scholar 

  39. Nagel KN, Schouten MG, Hambrock T, et al. Differentiation of prostatitis and prostate cancer by using diffusion-weighted MR imaging and MR-guided biopsy at 3 T. Radiology. 2013;267(1):164–72.

    Article  PubMed  Google Scholar 

  40. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11–30.

    Article  PubMed  Google Scholar 

  41. Chou R, Croswell JM, Dana T, et al. Screening for prostate cancer: a review of the evidence for the U.S. Preventive services task force. Ann Intern Med. 2011;155(11):762–71.

    Article  PubMed  Google Scholar 

  42. Makarov DV, Trock BJ, Humphreys EB, et al. Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy gleason score (partin tables) based on cases from 2000 to 2005. Urology. 2007;69(6):1095–101.

    Article  PubMed  Google Scholar 

  43. Dickinson L, FAU, Ahmed HU, Ahmed HU, et al. Magnetic resonance imaging for the detection, localisation, and characterisation of prostate cancer: recommendations from a European consensus meeting. Eur Urol. 2011;59(4):477–94. Epub 2010 Dec 21. (1873-7560 (Electronic); 0302-2838 (Linking)).

    Article  PubMed  Google Scholar 

  44. Hricak H. Given the improvement in pelvic coils for MR, is an endorectal coil necessary to evaluate prostate carcinoma? AJR Am J Roentgenol. 1995;165(3):733–4. 0361-803X (Print); 0361-803X (Linking).

    Article  CAS  PubMed  Google Scholar 

  45. Kirkham AP, Emberton M, Allen C. How good is MRI at detecting and characterising cancer within the prostate? Eur Urol. 2006;50(6):1163–74; discussion 1175.

    Article  PubMed  Google Scholar 

  46. Cruz M, Tsuda K, Narumi Y, et al. Characterization of low-intensity lesions in the peripheral zone of prostate on pre-biopsy endorectal coil MR imaging. Eur Radiol. 2002;12(2):357–65.

    Article  CAS  PubMed  Google Scholar 

  47. Qayyum A, Coakley FV, Lu Y, et al. Organ-confined prostate cancer: effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging. AJR Am J Roentgenol. 2004;183(4):1079–83.

    Article  PubMed  Google Scholar 

  48. Akin O, Sala E, Moskowitz CS, et al. Transition zone prostate cancers: features, detection, localization, and staging at endorectal MR imaging. Radiology. 2006;239(3):784–92.

    Article  PubMed  Google Scholar 

  49. Hricak H, FAU, White S, White S, et al. Carcinoma of the prostate gland: MR imaging with pelvic phased-array coils versus integrated endorectal – pelvic phased-array coils. Radiology. 1994;193(3):703–9. 0033-8419 (Print); 0033-8419 (Linking).

    Article  CAS  PubMed  Google Scholar 

  50. Scheidler J, Hricak H, Vigneron DB, et al. Prostate cancer: localization with three-dimensional proton MR spectroscopic imaging–clinicopathologic study. Radiology. 1999;213(2):473–80.

    Article  CAS  PubMed  Google Scholar 

  51. Haider MA, van der Kwast TH, Tanguay J, et al. Combined T2-weighted and diffusion-weighted MRI for localization of prostate cancer. AJR Am J Roentgenol. 2007;189(2):323–8.

    Article  PubMed  Google Scholar 

  52. Turkbey B, Pinto PA, Mani H, et al. Prostate cancer: value of multiparametric MR imaging at 3 T for detection–histopathologic correlation. Radiology. 2010;255(1):89–99.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Hambrock T, Somford DM, Huisman HJ, et al. Relationship between apparent diffusion coefficients at 3.0-T MR imaging and gleason grade in peripheral zone prostate cancer. Radiology. 2011;259(2):453–61.

    Article  PubMed  Google Scholar 

  54. Stejskal EOTJ. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys. 1965;42(1):288–92.

    Article  CAS  Google Scholar 

  55. Kim CK, Park BK, Kim B. High-b-value diffusion-weighted imaging at 3 T to detect prostate cancer: comparisons between b values of 1,000 and 2,000 s/mm2. AJR Am J Roentgenol. 2010;194(1):W33–7.

    Article  PubMed  Google Scholar 

  56. Zelhof B, Pickles M, Liney G, et al. Correlation of diffusion-weighted magnetic resonance data with cellularity in prostate cancer. BJU Int. 2009;103(7):883–8.

    Article  PubMed  Google Scholar 

  57. Langer DL, van der Kwast TH, Evans AJ, Trachtenberg J, Wilson BC, Haider MA. Prostate cancer detection with multi-parametric MRI: logistic regression analysis of quantitative T2, diffusion-weighted imaging, and dynamic contrast-enhanced MRI. J Magn Reson Imaging. 2009;30(2):327–34.

    Article  PubMed  Google Scholar 

  58. Huisman HJ, Engelbrecht MR, Barentsz JO. Accurate estimation of pharmacokinetic contrast-enhanced dynamic MRI parameters of the prostate. J Magn Reson Imaging. 2001;13(4):607–14.

    Article  CAS  PubMed  Google Scholar 

  59. Hoeks CM, Barentsz JO, Hambrock T, et al. Prostate cancer: multiparametric MR imaging for detection, localization, and staging. Radiology. 2011;261(1):46–66.

    Article  PubMed  Google Scholar 

  60. Tofts PS, Brix G, Buckley DL, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999;10(3):223–32.

    Article  CAS  PubMed  Google Scholar 

  61. Futterer JJ, FAU, Heijmink SWTPJ, Heijmink SW, et al. Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging. Radiology. 2006;241(2):449–58. Epub 2006 Sep 11. (0033-8419 (Print); 0033-8419 (Linking)).

    Article  PubMed  Google Scholar 

  62. Jager GJ, Ruijter ET, van de Kaa CA, et al. Dynamic TurboFLASH subtraction technique for contrast-enhanced MR imaging of the prostate: correlation with histopathologic results. Radiology. 1997;203(3):645–52.

    Article  CAS  PubMed  Google Scholar 

  63. Padhani AR, Gapinski CJ, Macvicar DA, et al. Dynamic contrast enhanced MRI of prostate cancer: correlation with morphology and tumour stage, histological grade and PSA. Clin Radiol. 2000;55(2):99–109.

    Article  CAS  PubMed  Google Scholar 

  64. Futterer JJ, Engelbrecht MR, Huisman HJ, et al. Staging prostate cancer with dynamic contrast-enhanced endorectal MR imaging prior to radical prostatectomy: experienced versus less experienced readers. Radiology. 2005;237(2):541–9.

    Article  PubMed  Google Scholar 

  65. Bloch BN, Furman-Haran E, Helbich TH, et al. Prostate cancer: accurate determination of extracapsular extension with high-spatial-resolution dynamic contrast-enhanced and T2-weighted MR imaging–initial results. Radiology. 2007;245(1):176–85.

    Article  PubMed  Google Scholar 

  66. Coakley FV, Qayyum A, Kurhanewicz J. Magnetic resonance imaging and spectroscopic imaging of prostate cancer. J Urol. 2003;170(6 Pt 2):S69–75; discussion S75–6.

    PubMed  Google Scholar 

  67. Delongchamps NB, Rouanne M, Flam T, et al. Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging. BJU Int. 2011;107(9):1411–8.

    Article  PubMed  Google Scholar 

  68. Hricak H, White S, Vigneron D, et al. Carcinoma of the prostate gland: MR imaging with pelvic phased-array coils versus integrated endorectal–pelvic phased-array coils. Radiology. 1994;193(3):703–9.

    Article  CAS  PubMed  Google Scholar 

  69. Turkbey B, FAU, Mani H, Mani H, et al. Multiparametric 3T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds. J Urol. 2011;186(5):1818–24. Epub 2011 Sep 25. (1527-3792 (Electronic); 0022-5347 (Linking)).

    Article  PubMed  PubMed Central  Google Scholar 

  70. Haas GP, Delongchamps NB, Jones RF, et al. Needle biopsies on autopsy prostates: sensitivity of cancer detection based on true prevalence. J Natl Cancer Inst. 2007;99(19):1484–9.

    Article  PubMed  Google Scholar 

  71. Serefoglu EC, Altinova S, Ugras NS, Akincioglu E, Asil E, Balbay MD. How reliable is 12-core prostate biopsy procedure in the detection of prostate cancer? Can Urol Assoc J. 2012;2:1–6.

    Google Scholar 

  72. Moore CM, Robertson NL, Arsanious N, et al. Image-guided prostate biopsy using magnetic resonance imaging-derived targets: a systematic review. Eur Urol. 2013;63(1):125–40.

    Article  PubMed  Google Scholar 

  73. Pinto PA, FAU, Chung PH, Chung PH, et al. Magnetic resonance imaging/ultrasound fusion guided prostate biopsy improves cancer detection following transrectal ultrasound biopsy and correlates with multiparametric magnetic resonance imaging. J Urol. 2011;186(4):1281–5. Epub 2011 Aug 17. (1527-3792 (Electronic); 0022-5347 (Linking)).

    Article  PubMed  PubMed Central  Google Scholar 

  74. Vourganti S, FAU, Rastinehad A, Rastinehad A, et al. Multiparametric magnetic resonance imaging and ultrasound fusion biopsy detect prostate cancer in patients with prior negative transrectal ultrasound biopsies. J Urol. 2012. doi:10.1016/j.juro.2012.08.025. LID – S0022-5347(12)04482-5 [pii] LID – 10.1016/j.juro.2012.08.025 [doi]. pii: S0022-5347(12)04482-5. (1527-3792 (Electronic); 0022-5347 (Linking)).

    Article  PubMed  PubMed Central  Google Scholar 

  75. Siddiqui MM, Rais-Bahrami S, Truong H, et al. Magnetic resonance imaging/ultrasound-fusion biopsy significantly upgrades prostate cancer versus systematic 12-core transrectal ultrasound biopsy. Eur Urol 2013;64:713–9.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Puech P, Rouviere O, Renard-Penna R, et al. Prostate cancer diagnosis: multiparametric MR-targeted biopsy with cognitive and transrectal US-MR fusion guidance versus systematic biopsy–prospective multicenter study. Radiology. 2013;268(2):461–9.

    Article  PubMed  Google Scholar 

  77. Beyersdorff D, Taymoorian K, Knosel T, et al. MRI of prostate cancer at 1.5 and 3.0 T: comparison of image quality in tumor detection and staging. AJR Am J Roentgenol. 2005;185(5):1214–20.

    Article  PubMed  Google Scholar 

  78. Augustin H, Fritz GA, Ehammer T, Auprich M, Pummer K. Accuracy of 3-tesla magnetic resonance imaging for the staging of prostate cancer in comparison to the partin tables. Acta Radiol. 2009;50(5):562–9.

    Article  CAS  PubMed  Google Scholar 

  79. Futterer JJ, Engelbrecht MR, Jager GJ, et al. Prostate cancer: comparison of local staging accuracy of pelvic phased-array coil alone versus integrated endorectal-pelvic phased-array coils. Local staging accuracy of prostate cancer using endorectal coil MR imaging. Eur Radiol. 2007;17(4):1055–65.

    Article  PubMed  Google Scholar 

  80. Hricak H, Wang L, Wei DC, et al. The role of preoperative endorectal magnetic resonance imaging in the decision regarding whether to preserve or resect neurovascular bundles during radical retropubic prostatectomy. Cancer. 2004;100(12):2655–63.

    Article  PubMed  Google Scholar 

  81. Jager GJ, Ruijter ET, van de Kaa CA, et al. Local staging of prostate cancer with endorectal MR imaging: correlation with histopathology. AJR Am J Roentgenol. 1996;166(4):845–52.

    Article  CAS  PubMed  Google Scholar 

  82. Heenan SD. Magnetic resonance imaging in prostate cancer. Prostate Cancer Prostatic Dis. 2004;7(4):282–8.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Juan J. Ibarra-Rovira MD or Michael R. Da Rosa MD .

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Ibarra-Rovira, J.J., Da Rosa, M.R., Haider, M.A. (2015). Prostate Imaging. In: Elsayes, K.M. (eds) Cross-Sectional Imaging of the Abdomen and Pelvis. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1884-3_20

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