The Irreversibility of Organ Injury
In the adult mammal, injury to the stroma is typically irreversible and leads to formation of nonphysiological scar tissue (repair). Every organ in the adult can be irreversibly injured, resulting in repair with scar formation. In certain organs injury is irreversible when it leads to damage of specific tissues while in others it becomes irreversible when the injury exceeds a critical size.
The topic of this volume, induced regeneration, is a process in which physiological tissue, rather than scar, is deliberately synthesized at the anatomical site of the adult host that has been irreversibly injured. This approach is embodied in the collagen scaffold regeneration paradigm, based on five empirical rules, which explains at each of the scales of tissue, cell, and molecule, the mechanism of induced regeneration.