Drug Addiction and Chronic Pain: A Review of Animal Models

  • Carrie L. Wade
  • George F. Koob
  • Leandro F. Vendruscolo
Part of the Contemporary Clinical Neuroscience book series (CCNE, volume 17)


Animal models of pain play an important role in the characterization and development of therapeutics for several pain conditions. Models that mimic the development and maintenance of chronic pain conditions are especially important and have directly impacted the availability of treatments for many common pain conditions such as neuropathic, inflammatory, and visceral. The most efficacious and first choice treatment option for chronic pain is opioid analgesics. Besides being potent analgesics, opioids produce an intense pleasant feeling (reward), especially in individuals not suffering actual pain. This raises the concern that the chronic treatment of pain with opioids can cause opioid tolerance and dependence. This chapter discusses the animal models that are used to quantitatively measure nociception and analgesia, and animal models that are used to study inflammatory, neuropathic, and visceral pain. Additionally, we discuss the animal models used to study opioid dependence.


Chronic Pain Neuropathic Pain Lever Press Chronic Constriction Injury Opioid Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Carrie L. Wade
    • 1
  • George F. Koob
    • 1
  • Leandro F. Vendruscolo
    • 1
  1. 1.Committee on the Neurobiology of Addictive Disorders, The Scripps Research InstituteLa JollaUSA

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