Spinal Cord Stimulation

  • W. Porter McRoberts
  • Daniel M. Doleys
  • Kevin D. Cairns


Great innovation in patient selection, expertise, and technology has yielded spinal cord stimulation as a treatment which when skillfully applied offers significant and reliable chronic pain relief at the patient’s own direction. This chapter presents an overview of the practical application of spinal cord stimulation, focusing on patient selection, mechanism of action, outcomes and effectiveness data, psychological assessment and screening, as well as future directions. Lastly, the chapter reviews potential complications and presents considerations for virtually every step in neuromodulation but especially for surgical methodology to mitigate risk and increase chances of success. Along with traditional thoracic lead placement, cervical and retrograde approaches are additionally explained and detailed.


Electrode Array Complex Regional Pain Syndrome Spinal Cord Stimulation Dorsal Column Ligamentum Flavum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Shealy CN, Mortimer JT, Resnick JB. Electrical inhibition of pain by stimulation of the dorsal columns: preliminary clinical reports. Anesth Analg. 1967;46(4):489–91.PubMedGoogle Scholar
  2. 2.
    Committee on Advancing Pain Research, Care, and Education; Institute of Medicine. Relieving pain in America: a blueprint for transforming prevention, care, education, and research. Washington, DC: The National Academies Press; 2011.Google Scholar
  3. 3.
    Von Korff M, Dworkin SF, Le Resche L. Graded chronic pain status: an epidemiologic evaluation. Pain. 1990;40(3):279–91.Google Scholar
  4. 4.
    Merskey H, Bogduk N. Classification of chronic pain. 2nd ed. Seattle: IASP Press; 1994.Google Scholar
  5. 5.
    Gildenberg PL. History of electrical neuromodulation for chronic pain. Pain Med. 2006;7(S1):S7–13.Google Scholar
  6. 6.
    Stillings D. A survey of the history of electrical stimulation for pain to 1900. Med Instrum. 1975;9(6):255–9.PubMedGoogle Scholar
  7. 7.
    Schechter DC. Origins of electrotherapy. Part 1. N Y State J Med. 1971;71(9):997–1008.PubMedGoogle Scholar
  8. 8.
    Miguel R. Interventional treatment of cancer pain: the fourth step in the World Health Organization analgesic ladder? Cancer Control. 2000;7:149–56.PubMedGoogle Scholar
  9. 9.
    Beard GM, Rockwell AD. A practical treatise on the medical and surgical uses of electricity. New York: William Wood & Co; 1871.Google Scholar
  10. 10.
    Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(699):971–9.PubMedGoogle Scholar
  11. 11.
    Buonocore M, Bonezzi C, Barolat G. Neurophysiological evidence of antidromic activation of large myelinated fibres in lower limbs during spinal cord stimulation. Spine. 2008;33(4):E90.PubMedGoogle Scholar
  12. 12.
    Song Z, Ultenius C, Meyerson BA, Linderoth B. Pain relief by spinal cord stimulation involves serotonergic mechanisms: an experimental study in a rat model of mononeuropathy. Pain. 2009;147(1–3):241–8.PubMedGoogle Scholar
  13. 13.
    Song Z, Meyerson BA, Linderoth B. Spinal 5-HT receptors that contribute to the pain-relieving effects of spinal cord stimulation in a rat model of neuropathy. Pain. 2011;152(7):1666–73.PubMedGoogle Scholar
  14. 14.
    Kemler MA, Barendse GAM, van Kleef M, Egbrink MGA. Pain relief in complex regional pain syndrome due to spinal cord stimulation does not depend on vasodilation. Anesthesiology. 2000;92(6):1653.PubMedGoogle Scholar
  15. 15.
    Meyerson BA, Linderoth B. Mode of action of spinal cord stimulation in neuropathic pain. J Pain Symptom Manage. 2006;31(4):S6–12.PubMedGoogle Scholar
  16. 16.
    Aló KM. Lead positioning and programming strategies in the treatment of complex pain. Neuromodulation. 1999;2(3):165–70.PubMedGoogle Scholar
  17. 17.
    De Ridder D, Vanneste S, Plazier M, van der Loo E, Menovsky T. Burst spinal cord stimulation: toward paresthesia-free pain suppression. Neurosurgery. 2010;66(5):986.PubMedGoogle Scholar
  18. 18.
    Kiriakopoulos ET, Tasker RR, Nicosia S, Wood ML, Mikulis DJ. Functional magnetic resonance imaging: a potential tool for the evaluation of spinal cord stimulation: technical case report. Neurosurgery. 1997;41(2):501.PubMedGoogle Scholar
  19. 19.
    Kovacs S, Peeters R, De Ridder D, Plazier M, Menovsky T, Sunaert S. Central effects of occipital nerve electrical stimulation studied by functional magnetic resonance imaging. Neuromodulation. 2011;14(1):46–57.PubMedGoogle Scholar
  20. 20.
    Kumar K, Hunter G, Demeria D. Spinal cord stimulation in treatment of chronic benign pain: challenges in treatment planning and present status, a 22-year experience. Neurosurgery. 2006;58(3):481.PubMedGoogle Scholar
  21. 21.
    Kumar K, Toth C, Nath RK, Laing P. Epidural spinal cord stimulation for treatment of chronic pain–some predictors of success. A 15-year experience. Surg Neurol. 1998;50(2):110–21.PubMedGoogle Scholar
  22. 22.
    North RB, Kidd DH, Farrokhi F, Piantadosi SA. Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain: a randomized, controlled trial. Neurosurgery. 2005;56(1):98–106.PubMedGoogle Scholar
  23. 23.
    Kumar K, Taylor RS, Jacques L, Eldabe S, Meglio M, Molet J, et al. The effects of spinal cord stimulation in neuropathic pain are sustained: a 24-month follow-up of the prospective randomized controlled multicenter trial of the effectiveness of spinal cord stimulation. Neurosurgery. 2008;63(4):762–70; discussion 770.PubMedGoogle Scholar
  24. 24.
    North RB, Kidd D, Shipley J, Taylor RS. Spinal cord stimulation versus reoperation for failed back surgery syndrome: a cost effectiveness and cost utility analysis based on a randomized, controlled trial. Neurosurgery. 2007;61(2):361–8; discussion 368–9.PubMedGoogle Scholar
  25. 25.
    Börjesson M, Andrell P, Lundberg D, Mannheimer C. Spinal cord stimulation in severe angina pectoris – a systematic review based on the Swedish Council on Technology assessment in health care report on long-standing pain. Pain. 2008;140(3):501–8.PubMedGoogle Scholar
  26. 26.
    Claeys LGY. Effects of spinal cord stimulation on nutritional skin blood flow in patients with ischemic pain. Neuromodulation. 2000;3(3):123–30.PubMedGoogle Scholar
  27. 27.
    Yakovlev AE, Peterson AT. Peripheral nerve stimulation in treatment of intractable postherpetic neuralgia. Neuromodulation. 2007;10(4):373–5.PubMedGoogle Scholar
  28. 28.
    Yakovlev AE, Resch BE, Karasev SA. Treatment of cancer-related chest wall pain using spinal cord stimulation. Am J Hosp Palliat Med. 2010;27(8):552–6.Google Scholar
  29. 29.
    Eisenberg E, Brecker C. Lumbar spinal cord stimulation for cervical-originated central pain: a case report. Pain. 2002;100(3):299–301.PubMedGoogle Scholar
  30. 30.
    Burkey AR, Abla-Yao S. Successful treatment of central pain in a multiple sclerosis patient with epidural stimulation of the dorsal root entry zone. Pain med. 2010;11(1):127–32.PubMedGoogle Scholar
  31. 31.
    Mekhail N, Wentzel DL, Freeman R, Quadri H. Counting the costs: case management implications of spinal cord stimulation treatment for failed back surgery syndrome. Prof Case Manag. 2011;16(1):27–36.PubMedGoogle Scholar
  32. 32.
    Van Buyten JP, Van Zundert J, Vueghs P, Vanduffel L. Efficacy of spinal cord stimulation: 10 years of experience in a pain centre in Belgium. Eur J Pain. 2001;5(3):299–307.PubMedGoogle Scholar
  33. 33.
    Cameron T. Safety and efficacy of spinal cord stimulation for the treatment of chronic pain: a 20-year literature review. J Neurosurg. 2004;100(3 Suppl Spine):254–67.PubMedGoogle Scholar
  34. 34.
    Mailis-Gagnon A, Furlan A, Sandoval J, Taylor R. Spinal cord stimulation for chronic pain. Cochrane Database Syst Rev. 2004; (3):CD003783.Google Scholar
  35. 35.
    Taylor RS, Taylor RJ, Van Buyten JP, Buchser E, North R, Bayliss S. The cost effectiveness of spinal cord stimulation in the treatment of pain: a systematic review of the literature. J Pain Symptom Manage. 2004;27(4):370–8.PubMedGoogle Scholar
  36. 36.
    May MS, Banks C, Thomson SJ. A retrospective, long-term, third-party follow-up of patients considered for spinal cord stimulation. Neuromodulation. 2002;5(3):137–44.PubMedGoogle Scholar
  37. 37.
    Daniel MS, Long C, Hutcherson W, Hunter S. Psychological factors and outcome of electrode implantation for chronic pain. Neurosurgery. 1985;17(5):773–7.PubMedGoogle Scholar
  38. 38.
    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed (DSM–IV). Washington, DC: American Psychiatric Association; 1994.Google Scholar
  39. 39.
    Nelson DV, Kennington M, Novy DM, Squitieri P. Psychological selection criteria for implantable spinal cord stimulators. Pain Forum. 1996;5(2):93–103.Google Scholar
  40. 40.
    Doleys DM. Psychologic evaluation for patients undergoing neuroaugmentative procedures. Neurosurg Clin N Am. 2003;14(3):409–17.PubMedGoogle Scholar
  41. 41.
    Peng PWH, Fedoroff I, Jacques L, Kumar K. Survey of the practice of spinal cord stimulators and intrathecal analgesic delivery implants for management of pain in Canada. Pain Res Manag. 2007;12(4):281–5.PubMedCentralPubMedGoogle Scholar
  42. 42.
    Ackroyd R, Bush DJ, Graves J, McVey J, Horton S. Survey of assessment criteria prior to implantation of spinal cord stimulators in United Kingdom pain management centres. Eur J Pain. 2005;9(1):57–60.PubMedGoogle Scholar
  43. 43.
    Turner JA, Hollingworth W, Comstock BA, Deyo RA. Spinal cord stimulation for failed back surgery syndrome: outcomes in a workers’ compensation setting. Pain. 2010;148(1):14–25.PubMedGoogle Scholar
  44. 44.
    Celestin J, Edwards RR, Jamison RN. Pretreatment psychosocial variables as predictors of outcomes following lumbar surgery and spinal cord stimulation: a systematic review and literature synthesis. Pain Med. 2009;10(4):639–53.PubMedGoogle Scholar
  45. 45.
    Sparkes E, Raphael JH, Duarte RV, LeMarchand K, Jackson C, Ashford RL. A systematic literature review of psychological characteristics as determinants of outcome for spinal cord stimulation therapy. Pain. 2010;150(2):284–9.PubMedGoogle Scholar
  46. 46.
    Butcher J, Dahlstrom W, Graham J, Tellegen A, Kaemmer B. Minnesota multiphasic personality inventory-2 (MMPI-2): manual for administration and scoring. Minneapolis: University of Minnesota Press; 1989.Google Scholar
  47. 47.
    Heckler DR, Gatchel RJ, Lou L, Whitworth T, Bernstein D, Stowell AW. Presurgical behavioral medicine evaluation (PBME) for implantable devices for pain management: a 1-year prospective study. Pain Pract. 2007;7(2):110–22.PubMedGoogle Scholar
  48. 48.
    Molloy AR, Nicholas MK, Asghari A, Beeston LR, Dehghani M, Cousins MJ, et al. Does a combination of intensive cognitive-behavioral pain management and a spinal implantable device confer any advantage? A preliminary examination. Pain Pract. 2006;6(2):96–103.PubMedGoogle Scholar
  49. 49.
    Dumoulin K, Devulder J, Castille F, De Laat M, Van Bastelaere M, Rolly G. A psychoanalytic investigation to improve the success rate of spinal cord stimulation as a treatment for chronic failed back surgery syndrome. Clin J Pain. 1996;12(1):43–9.PubMedGoogle Scholar
  50. 50.
    Lamé IE, Peters ML, Patijn J, Kessels AG, Geurts J, van Kleef M. Can the outcome of spinal cord stimulation in chronic complex regional pain syndrome type I patients be predicted by catastrophizing thoughts? Anesth Analg. 2009;109(2):592–9.PubMedGoogle Scholar
  51. 51.
    North RB, Kidd DH, Wimberly RL, Edwin D. Prognostic value of psychological testing in patients undergoing spinal cord stimulation: a prospective study. Neurosurgery. 1996;39(2):301–10; discussion 310–1.PubMedGoogle Scholar
  52. 52.
    Kupers RC, Van den Oever R, Van Houdenhove B, Vanmechelcn W, Hepp B, Nuttin B, et al. Spinal cord stimulation in Belgium: a nation-wide survey on the incidence, indications and therapeutic efficacy by the health insurer. Pain. 1994;56(2):211–6.PubMedGoogle Scholar
  53. 53.
    Beck AT, Steer RA, Carbin MG. Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation. Clin Psychol Rev. 1988;8(1):77–100.Google Scholar
  54. 54.
    Fairbank JC, Couper J, Davies JB, O’Brien JP. The Oswestry low back pain disability questionnaire. Physiotherapy. 1980;66(8):271–3.PubMedGoogle Scholar
  55. 55.
    Deyo RA, Battie M, Beurskens AJ, Bombardier C, Croft P, Koes B, et al. Outcome measures for low back pain research. A proposal for standardized use. Spine. 1998;23(18):2003–13.PubMedGoogle Scholar
  56. 56.
    Doleys DM. Psychological assessment for implantable therapies. Pain Dig. 2000;10:16–23.Google Scholar
  57. 57.
    Doleys DM. Preparing patients for implantable technology. In: Turk DC, Gatchel R, editors. Psychological aspect of pain management. New York: Guilford Press; 2002. p. 334–47.Google Scholar
  58. 58.
    American Psychological Association. Ethical Principles of Psychologists and Code of Conduct. Accessed March 24, 2010.
  59. 59.
    Doleys DM. Psychological factors in spinal cord stimulation therapy: brief review and discussion. Neurosurg Focus. 2006;21(6):E1–6.PubMedGoogle Scholar
  60. 60.
  61. 61.
    Doleys DM, Klapow J, Hammer M. Psychological evaluation in spinal cord stimulation. Pain Rev. 1997;4:186–207.Google Scholar
  62. 62.
    Deer TR, Stewart CD. Complications of spinal cord stimulation: identification, treatment, and prevention. Pain Med. 2008;9(S1):S93–101.Google Scholar
  63. 63.
    Turner JA, Loeser JD, Deyo RA, Sanders SB. Spinal cord stimulation for patients with failed back surgery syndrome or complex regional pain syndrome: a systematic review of effectiveness and complications. Pain. 2004;108(1–2):137–47.PubMedGoogle Scholar
  64. 64.
    Kumar A, Felderhof C, Eljamel MS. Spinal cord stimulation for the treatment of refractory unilateral limb pain syndromes. Stereotact Funct Neurosurg. 2003;81(1–4):70–4.PubMedGoogle Scholar
  65. 65.
    Smith CC, Lin JL, Shokat M, Dosanjh SS, Casthely D. A report of paraparesis following spinal cord stimulator trial, implantation and revision. Pain Physician. 2010;13(4):357–63.PubMedGoogle Scholar
  66. 66.
    Edmiston Jr CE, Okoli O, Graham MB, Sinski S, Seabrook GR. Evidence for using chlorhexidine gluconate preoperative cleansing to reduce the risk of surgical site infection. AORN J. 2010;92(5):509–18.PubMedGoogle Scholar
  67. 67.
    Epstein N. Preoperative, intraoperative, and postoperative measures to further reduce spinal infections. Surg Neurol Int. 2011;2:17.PubMedCentralPubMedGoogle Scholar
  68. 68.
    Alexander JW, Fischer JE, Boyajian M, Palmquist J, Morris MJ. The influence of hair-removal methods on wound infections. Arch Surg. 1983;118(3):347–52.PubMedGoogle Scholar
  69. 69.
    Cruse PJ, Foord R. The epidemiology of wound infection. A 10-year prospective study of 62,939 wounds. Surg Clin North Am. 1980;60(1):27–40.PubMedGoogle Scholar
  70. 70.
    Follett KA, Boortz-Marx RL, Drake JM, DuPen S, Schneider SJ, Turner MS, et al. Prevention and management of intrathecal drug delivery and spinal cord stimulation system infections. Anesthesiology. 2004;100(6):1582–94.PubMedGoogle Scholar
  71. 71.
    Kumar K, Buchser E, Linderoth B, Meglio M, Van Buyten J. Avoiding complications from spinal cord stimulation: practical recommendations from an international panel of experts. Neuromodulation. 2007;10(1):24–33.PubMedGoogle Scholar
  72. 72.
    Centers for Disease Control and Prevention. Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR. 2002;51:1–45.Google Scholar
  73. 73.
    Darouiche RO, Wall Jr MJ, Itani KMF, Otterson MF, Webb AL, Carrick MM, et al. Chlorhexidine–alcohol versus povidone–iodine for surgical-site antisepsis. N Engl J Med. 2010;362(1):18–26.PubMedGoogle Scholar
  74. 74.
    Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med. 2002;136(11):792–801.PubMedGoogle Scholar
  75. 75.
    Holsheimer J, Barolat G. Spinal geometry and paresthesia coverage in spinal cord stimulation. Neuromodulation. 1998;1(3):129–36.Google Scholar
  76. 76.
    Holsheimer J. Principles of neurostimulation. In: Simpson BA, editor. Electrical stimulation and the relief of pain, Pain research and clinical management, vol. 15. Amsterdam, Boston: Elsevier; 2003. p. 17–36.Google Scholar
  77. 77.
    Aló KM, Holsheimer J. New trends in neuromodulation for the management of neuropathic pain. Neurosurgery. 2002;50(4):690–703; discussion 703–4.PubMedGoogle Scholar
  78. 78.
    Zhu J, Falco F, Onyewu CO, Joesphson Y, Vesga R, Jari R. Alternative approach to needle placement in spinal cord stimulator trial/implantation. Pain Physician. 2011;14(1):45–53.PubMedGoogle Scholar
  79. 79.
    Eldrige JS, Weingarten TN, Rho RH. Management of cerebral spinal fluid leak complicating spinal cord stimulator implantation. Pain Pract. 2006;6(4):285–8.PubMedGoogle Scholar
  80. 80.
    Holsheimer J. Does dual lead stimulation favor stimulation of the axial lower back? Neuromodulation. 2000;3(2):55–7.PubMedGoogle Scholar
  81. 81.
    Holsheimer J, Buitenweg JR, Das J, de Sutter P, Manola L, Nuttin B. The effect of pulse width and contact configuration on paresthesia coverage in spinal cord stimulation. Neurosurgery. 2011;68(5):1452–61.PubMedGoogle Scholar
  82. 82.
    Holsheimer J, Struijk JJ, Wesselink WA. Analysis of spinal cord stimulation and design of epidural electrodes by computer modeling. Neuromodulation. 1998;1(1):14–8.PubMedGoogle Scholar
  83. 83.
    Feirabend HKP, Choufoer H, Ploeger S, Holsheimer J, van Gool JD. Morphometry of human superficial dorsal and dorsolateral column fibres: significance to spinal cord stimulation. Brain. 2002;125(5):1137–49.PubMedGoogle Scholar
  84. 84.
    Holsheimer J. Concepts and methods in neuromodulation and functional electrical stimulation: an introduction. Neuromodulation. 1998;1(2):57–61.PubMedGoogle Scholar
  85. 85.
    Holsheimer J, Khan YN, Raza SS, Khan EA. Effects of electrode positioning on perception threshold and paresthesia coverage in spinal cord stimulation. Neuromodulation. 2007;10(1):34–41.PubMedGoogle Scholar
  86. 86.
    Holsheimer J. Which neuronal elements are activated directly by spinal cord stimulation. Neuromodulation. 2002;5(1):25–31.PubMedGoogle Scholar
  87. 87.
    Holsheimer J, Nuttin B, King GW, Wesselink WA, Gybels JM, de Sutter P. Clinical evaluation of paresthesia steering with a new system for spinal cord stimulation. Neurosurgery. 1998;42(3):541.PubMedGoogle Scholar
  88. 88.
    Holsheimer J, Struijk JJ, Rijkhoff NJM. Contact combinations in epidural spinal cord stimulation. Stereotact Funct Neurosurg. 1991;56(4):220–33.PubMedGoogle Scholar
  89. 89.
    Holsheimer J, Wesselink WA. Effect of anode–cathode configuration on paresthesia coverage in spinal cord stimulation. Neurosurgery. 1997;41(3):654.PubMedGoogle Scholar
  90. 90.
    Holsheimer J. Effectiveness of spinal cord stimulation in the management of chronic pain: analysis of technical drawbacks and solutions. Neurosurgery. 1997;40(5):990.PubMedGoogle Scholar
  91. 91.
    Holsheimer J, Struijk JJ. How do geometric factors influence epidural spinal cord stimulation? Stereotact Funct Neurosurg. 1991;56(4):234–49.PubMedGoogle Scholar
  92. 92.
    Renard VM, North RB. Prevention of percutaneous electrode migration in spinal cord stimulation by a modification of the standard implantation technique. J Neurosurg Spine. 2006;4(4):300–3.PubMedGoogle Scholar
  93. 93.
    Rosenow JM, Stanton-Hicks M, Rezai AR, Henderson JM. Failure modes of spinal cord stimulation hardware. J Neurosurg Spine. 2006;5(3):183–90.PubMedGoogle Scholar
  94. 94.
    Mackenzie A, Laing R, Smith C, Kaar G, Smith F. Spinal epidural abscess: the importance of early diagnosis and treatment. J Neurol Neurosurg Psychiatry. 1998;65(2):209–12.PubMedCentralPubMedGoogle Scholar
  95. 95.
    Kloss BT, Sullivan AM, Rodriguez E. Epidural hematoma following spinal cord stimulator implant. Int J Emerg Med. 2010;3(4):483–4.PubMedCentralPubMedGoogle Scholar
  96. 96.
    Aló KM, Redko V, Charnov J. Four year follow‐up of dual electrode spinal cord stimulation for chronic pain. Neuromodulation. 2002;5(2):79–88.PubMedGoogle Scholar
  97. 97.
    North RB, Kidd DH, Olin J, Sieracki JM, Farrokhi F, Petrucci L, et al. Spinal cord stimulation for axial low back pain: a prospective, controlled trial comparing dual with single percutaneous electrodes. Spine. 2005;30(12):1412–8.PubMedGoogle Scholar
  98. 98.
    Struijk JJ, Holsheimer J. Transverse tripolar spinal cord stimulation: theoretical performance of a dual channel system. Med Biol Eng Comput. 1996;34(4):273–9.PubMedGoogle Scholar
  99. 99.
    Struijk JJ, Holsheimer J, Spincemaille GHJ, Gielen FLH, Hoekema R. Theoretical performance and clinical evaluation of transverse tripolar spinal cord stimulation. IEEE Trans Rehabil Eng. 1998;6:277–85.PubMedGoogle Scholar
  100. 100.
    Wesselink WA, Holsheimer J, King GW, Torgerson NA, Boom HBK. Quantitative aspects of the clinical performance of transverse tripolar spinal cord stimulation. Neuromodulation. 1999;2(1):5–14.PubMedGoogle Scholar
  101. 101.
    Oakley JC, Espinosa F, Bothe H, McKean J, Allen P, Burchiel K, et al. Transverse tripolar spinal cord stimulation: results of an international multicenter study. Neuromodulation. 2006;9(3):192–203.PubMedGoogle Scholar
  102. 102.
    Simpson BA, Bassett G, Davies K, Herbert C, Pierri M. Cervical spinal cord stimulation for pain: a report on 41 patients. Neuromodulation. 2003;6(1):20–6.PubMedGoogle Scholar
  103. 103.
    Vallejo R, Kramer J, Benyamin R. Neuromodulation of the cervical spinal cord in the treatment of chronic intractable neck and upper extremity pain: a case series and review of the literature. Pain Physician. 2007;10(2):305–11.PubMedGoogle Scholar
  104. 104.
    Chang P, Levy MR. High lateral cervical spinal cord stimulation (SCS) for neuropathic facial pain: report of 10 cases. Neurosurgery. 2010;67(2):550.Google Scholar
  105. 105.
    González-Darder JM, Canela P, González-Martinez V. High cervical spinal cord stimulation f or unstable angina pectoris. Stereotact Funct Neurosurg. 1991;56:20–7.PubMedGoogle Scholar
  106. 106.
    Hayek SM, Veizi IE, Stanton-Hicks M. Four-limb neurostimulation with neuroelectrodes placed in the lower cervical epidural space. Anesthesiology. 2009;110(3):681–4.PubMedGoogle Scholar
  107. 107.
    Osenbach RK. High cervical spinal cord stimulation for refractory craniocervical pain. Neurosurgery. 1998;43(3):674.Google Scholar
  108. 108.
    Robaina F, Clavo B, Catalá L, Caramés MÁ, Morera J. Blood flow increase by cervical spinal cord stimulation in middle cerebral and common carotid arteries. Neuromodulation. 2004;7(1):26–31.PubMedGoogle Scholar
  109. 109.
    Broseta J, García-March G, Sánchez-Ledesma MJ, Gonçalves J, Silva I, Barcia JA, et al. High-cervical spinal cord electrical stimulation in brain low perfusion syndromes: experimental basis and preliminary clinical report. Stereotact Funct Neurosurg. 1994;62(1–4):171–8.PubMedGoogle Scholar
  110. 110.
    Forouzanfar T, Kemler MA, Weber WEJ, Kessels AGH, van Kleef M. Spinal cord stimulation in complex regional pain syndrome: cervical and lumbar devices are comparably effective. Br J Anaesth. 2004;92(3):348–53.PubMedGoogle Scholar
  111. 111.
    Barolat G, Massaro F, He J, Zeme S, Ketcik B. Mapping of sensory responses to epidural stimulation of the intraspinal neural structures in man. J Neurosurg. 1993;78(2):233–9.PubMedGoogle Scholar
  112. 112.
    North RB, Fowler K, Nigrin DJ, Szymanski R. Patient-interactive, computer-controlled neurological stimulation system: clinical efficacy in spinal cord stimulator adjustment. J Neurosurg. 1992;76(6):967–72.PubMedGoogle Scholar
  113. 113.
    Nashold Jr BS, Friedman H. Dorsal column stimulation for control of pain. Preliminary report on 30 patients. J Neurosurg. 1972;36(5):590–7.PubMedGoogle Scholar
  114. 114.
    Coburn B. A theoretical study of epidural electrical stimulation of the spinal cord – part II: effects on long myelinated fibers. IEEE Trans Biomed Eng. 1985;32(11):978–86.PubMedGoogle Scholar
  115. 115.
    Struijk JJ, Holsheimer J, Boom HBK. Excitation of dorsal root fibers in spinal cord stimulation: a theoretical study. IEEE Trans Biomed Eng. 1993;40:632–9.PubMedGoogle Scholar
  116. 116.
    Irnich W. The chronaxie time and its practical importance. Pacing Clin Electrophysiol. 1980;3(3):292–301.PubMedGoogle Scholar
  117. 117.
    Mironer YE. Response to Henderson et al. “Prevention of mechanical failures in implanted spinal cord stimulation systems”. Neuromodulation. 2007;10(1):82–3.PubMedGoogle Scholar
  118. 118.
    Buvanendran A, Lubenow TJ. Efficacy of transverse tripolar spinal cord stimulator for the relief of chronic low back pain from failed back surgery. Pain Physician. 2008;11(3):333–8.PubMedGoogle Scholar
  119. 119.
    Mironer YE, Satterthwaite JR, Lewis EM, Haasis JC, LaTourette PC, Skoloff EM, et al. Efficacy of a single, percutaneous, across midline, Octrode® Lead using a “Midline Anchoring” technique in the treatment of chronic low back and/or lower extremity pain: a retrospective study. Neuromodulation. 2008;11(4):286–95.Google Scholar
  120. 120.
    Luyendijk W. The plica mediana dorsalis of the dura mater and its relation to lumbar peridurography (canalography). Neuroradiology. 1976;11(3):147–9.PubMedGoogle Scholar
  121. 121.
    Peláez E, Prieto Rodrigo MA, Muñoz Zurdo MM, Sánchez Montero FJ, Santos Lamas J, Muriel Villoria C. [Epidural spinal cord stimulation for interstitial cystitis]. Rev Esp Anestesiol Reanim. 2004;51(9):549–52.PubMedGoogle Scholar
  122. 122.
    Marcelissen T, Jacobs R, van Kerrebroeck P, de Wachter S. Sacral neuromodulation as a treatment for chronic pelvic pain. J Urol. 2011;186(2):387–93.PubMedGoogle Scholar
  123. 123.
    Pascual I, Gómez C de C, Ortega R, Toscano MJ, Marijuán JL, Espadas ML, et al. Sacral nerve stimulation for fecal incontinence. Rev Esp Enferm Dig. 2011; 103(7):355–9.Google Scholar
  124. 124.
    Yakovlev A, Karasev SA, Dolgich OY. Sacral nerve stimulation: a novel treatment of chronic anal fissure. Dis Colon Rectum. 2011;54(3):324–7.PubMedGoogle Scholar
  125. 125.
    Møiniche S, Mikkelsen S, Wetterslev J, Dahl JB. A qualitative systematic review of incisional local anaesthesia for postoperative pain relief after abdominal operations. Br J Anaesth. 1998;81(3):377–83.PubMedGoogle Scholar
  126. 126.
    Sekar C, Rajasekaran S, Kannan R, Reddy S, Shetty TAP, Pithwa YK. Preemptive analgesia for postoperative pain relief in lumbosacral spine surgeries: a randomized controlled trial. Spine J. 2004;4(3):261–4.PubMedGoogle Scholar
  127. 127.
    Raphael JH, Mutagi H, Hanu-Cernat D, Gandimani P, Kapur S. A cadaveric and in vitro controlled comparative investigation of percutaneous spinal cord lead anchoring. Neuromodulation. 2009;12(1):49–53.PubMedGoogle Scholar
  128. 128.
    Postlethwait RW. Long-term comparative study of nonabsorbable sutures. Ann Surg. 1970;171(6):892–8.PubMedCentralPubMedGoogle Scholar
  129. 129.
    Badia JM, Torres JM, Tur C, Sitges-Serra A. Saline wound irrigation reduces the postoperative infection rate in guinea pigs. J Surg Res. 1996;63(2):457–9.PubMedGoogle Scholar
  130. 130.
    Lord JW, Rossi G, Daliana M. Intraoperative antibiotic wound lavage: an attempt to eliminate postoperative infection in arterial and clean general surgical procedures. Ann Surg. 1977;185(6):634–41.PubMedCentralPubMedGoogle Scholar
  131. 131.
    Odland PB, Murakami CS. Simple suturing techniques and knot tying. In: Wheeland RG, editor. Cutaneous surgery. Philadelphia: WB Saunders; 1994. p. 178–88.Google Scholar

Copyright information

© American Academy of Pain Medicine 2015

Authors and Affiliations

  • W. Porter McRoberts
    • 1
  • Daniel M. Doleys
    • 2
  • Kevin D. Cairns
    • 3
    • 4
  1. 1.Department of Interventional Spine and Pain MedicineHoly Cross HospitalFort LauderdaleUSA
  2. 2.Pain and Rehabilitation InstituteBirminghamUSA
  3. 3.Department of Interventional Spine and Pain MedicineFlorida Spine SpecialistsFort LauderdaleUSA
  4. 4.Division of PM&RNova Southeastern UniversityFort LauderdaleUSA

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