Role of Cannabinoids in Pain Management

  • Ethan B. Russo
  • Andrea G. Hohmann


It is a curious fact that we owe a great deal of our insight into pharmacological treatment of pain to the plant world. Willow bark from Salix spp. led to development of aspirin and eventual elucidation of the analgesic effects of prostaglandins and their role in inflammation. The opium poppy (Papaver somniferum) provided the prototypic narcotic analgesic morphine, the first alkaloid discovered, and stimulated the much later discovery of the endorphin and enkephalin systems. Similarly, the pharmacological properties of cannabis (Cannabis sativa) prompted the isolation of Δ9-tetrahydrocannabinol (THC), the major psychoactive ingredient in cannabis, in 1964. It is this breakthrough that subsequently prompted the more recent discovery of the body’s own cannabis-like system, the endocannabinoid system (ECS), which modulates pain under physiological conditions.


Neuropathic Pain Chronic Neuropathic Pain Peripheral Neuropathic Pain Central Neuropathic Pain Sidestream Smoke 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© American Academy of Pain Medicine 2015

Authors and Affiliations

  1. 1.GW PharmaceuticalsVashonUSA
  2. 2.Pharmaceutical SciencesUniversity of MontanaMissoulaUSA
  3. 3.Department of Psychological and Brain SciencesIndiana UniversityBloomingtonUSA

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