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Vulvar Pathology pp 139–193Cite as

Infectious Diseases and Infestations of the Vulva

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Abstract

Genital infections have a high global prevalence and burden of disease. They carry significant morbidity and some of them even mortality worldwide. The impact in the health care system widens as the epidemiologic landscape is shifting in traditional infections like genital herpes and other sexually transmitted diseases.

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Abbreviations

CMV:

Cytomegalovirus

EBV:

Epstein Barr virus

HPV:

Human papilloma virus

HSV:

Herpes simplex virus

LGV:

Lymphogranuloma venereum

MC:

Molluscum contagiosum

SCCIS:

Squamous cell carcinoma in-situ

STD:

Sexual transmitted diseases

VZV:

Varicella-zoster virus

References

  1. Roett MA, Mayor MT, Uduhiri KA. Diagnosis and management of genital ulcers. Am Fam Physician. 2012;85(3):254–62.

    PubMed  Google Scholar 

  2. Looker KJ, Garnett GP, Schmid GP. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bull World Health Organ. 2008;86(10):805–12.

    PubMed Central  PubMed  Google Scholar 

  3. Whitley RJ, Kimberlin DW, Roizman B. Herpes simplex viruses. Clin Infect Dis. 1998;26(3):541–53. quiz 554–5.

    CAS  PubMed  Google Scholar 

  4. Bradley H, Markowitz LE, Gibson T, McQuillan GM. Seroprevalence of herpes simplex virus types 1 and 2–United States, 1999–2010. J Infect Dis. 2014; 209(3):325–33.

    PubMed  Google Scholar 

  5. Hofstetter AM, Rosenthal SL, Stanberry LR. Current thinking on genital herpes. Curr Opin Infect Dis. 2014;27(1):75–83.

    CAS  PubMed  Google Scholar 

  6. Kortekangas-Savolainen O, Orhanen E, Puodinketo T, Vuorinen T. Epidemiology of genital herpes simplex virus type 1 and 2 infections in southwestern Finland during a 10-year period (2003–2012). Sex Transm Dis. 2014;41(4):268–71.

    PubMed  Google Scholar 

  7. Tuokko H, Bloigu R, Hukkanen V. Herpes simplex virus type 1 genital herpes in young women: current trend in Northern Finland. Sex Transm Infect. 2014; 90(2):160.

    PubMed  Google Scholar 

  8. Roberts CM, Pfister JR, Spear SJ. Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students. Sex Transm Dis. 2003;30(10):797–800.

    PubMed  Google Scholar 

  9. Belshe RB, Leone PA, Bernstein DI, Wald A, Levin MJ, Stapleton JT, et al. Efficacy results of a trial of a herpes simplex vaccine. N Engl J Med. 2012;366(1): 34–43.

    CAS  PubMed Central  PubMed  Google Scholar 

  10. Bernstein DI, Bellamy AR, Hook EW, Levin MJ, Wald A, Ewell MG, et al. Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women. Clin Infect Dis. 2013;56(3): 344–51.

    CAS  PubMed Central  PubMed  Google Scholar 

  11. Langenberg AG, Corey L, Ashley RL, Leong WP, Straus SE. A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group. N Engl J Med. 1999; 341(19):1432–8.

    CAS  PubMed  Google Scholar 

  12. Ludwig RJ, Grundmann-Kollmann M, Holtmeier W, Wolter M, Glas J, Podda M, et al. Herpes simplex virus type 2-associated eosinophilic cellulitis (Wells’ syndrome). J Am Dermatol. 2003;48(5 Suppl): S60–1.

    Google Scholar 

  13. Griffith-Bauer K, O’Hearn M, Ehst BD. Chronic ulcerative herpes simplex virus infection of the vulva. Case Rep Dermatol. 2012;4(3):192–6.

    PubMed Central  PubMed  Google Scholar 

  14. Czelusta A, Yen-Moore A, Van der Straten M, Carrasco D, Tyring SK. An overview of sexually transmitted diseases. Part III. Sexually transmitted diseases in HIV-infected patients. J Am Dermatol. 2000;43(3):409–32; quiz 433–6.

    CAS  Google Scholar 

  15. Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS. 2006;20(1):73–83.

    PubMed  Google Scholar 

  16. Gray RH, Li X, Wawer MJ, Serwadda D, Sewankambo NK, Wabwire-Mangen F, et al. Determinants of HIV-1 load in subjects with early and later HIV infections, in a general-population cohort of Rakai, Uganda. J Infect Dis. 2004; 189(7):1209–15.

    PubMed  Google Scholar 

  17. Tronstein E, Johnston C, Huang M-L, Selke S, Magaret A, Warren T, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA. 2011;305(14): 1441–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  18. Wald A, Zeh J, Selke S, Ashley RL, Corey L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N Engl J Med. 1995;333(12):770–5.

    CAS  PubMed  Google Scholar 

  19. Phipps W, Saracino M, Magaret A, Selke S, Remington M, Huang M-L, et al. Persistent genital herpes simplex virus-2 shedding years following the first clinical episode. J Infect Dis. 2011;203(2): 180–7.

    PubMed Central  PubMed  Google Scholar 

  20. Choi SW, Yang JE, Kang SJ, Lee HR, Kim CW. Herpetic infection on the vulva associated with eccrine squamous syringometaplasia in malignant lymphoma. Acta Derm Venereol. 1999;79(6):500–1.

    CAS  PubMed  Google Scholar 

  21. Rose L, Herra CM, Crowley B. Evaluation of real-time polymerase chain reaction assays for the detection of herpes simplex virus in swab specimens. Eur J Clin Microbiol Infect Dis. 2008;27(9):857–61.

    CAS  PubMed  Google Scholar 

  22. Gitman MR, Ferguson D, Landry ML. Comparison of Simplexa HSV 1 & 2 PCR with culture, immunofluorescence, and laboratory-developed TaqMan PCR for detection of herpes simplex virus in swab specimens. J Clin Microbiol. 2013;51(11):3765–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  23. Philip KEJ, Goodman A, Pallawela SNS, Sathia L, Webster DP. A not so simplex case of genital herpes. BMJ Case Rep. 2013. doi:10.1136/bcr-2013-009993.

    PubMed  Google Scholar 

  24. Oaklander AL, Rissmiller JG. Postherpetic neuralgia after shingles: an under-recognized cause of chronic vulvar pain. Obstet Gynecol. 2002;99(4):625–8.

    PubMed  Google Scholar 

  25. Simon HK, Steele DW. Varicella: pediatric genital/rectal vesicular lesions of unclear origin. Ann Emerg Med. 1995;25(1):111–4.

    CAS  PubMed  Google Scholar 

  26. Cone RW, Hobson AC, Palmer J, Remington M, Corey L. Extended duration of herpes simplex virus DNA in genital lesions detected by the polymerase chain reaction. J Infect Dis. 1991;164(4):757–60.

    CAS  PubMed  Google Scholar 

  27. AbdullGaffar B, Raman LG, Muala AA. Cutaneous cytomegalovirus infection in a patient with acquired immunodeficiency syndrome. Int J Dermatol. 2008; 47(9):944–6.

    PubMed  Google Scholar 

  28. Ramdial PK, Dlova NC, Sydney C. Cytomegalovirus neuritis in perineal ulcers. J Cutan Pathol. 2002; 29(7):439–44.

    PubMed  Google Scholar 

  29. Choi Y-L, Kim J-A, Jang K-T, Kim D-S, Kim W-S, Lee J-H, et al. Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients. Br J Dermatol. 2006;155(5):977–82.

    PubMed  Google Scholar 

  30. Daudén E, Fernández-Buezo G, Fraga J, Cardeñoso L, García-Díez A. Mucocutaneous presence of cytomegalovirus associated with human immunodeficiency virus infection: discussion regarding its pathogenetic role. Arch Dermatol. 2001;137(4): 443–8.

    PubMed  Google Scholar 

  31. Resnik KS, DiLeonardo M, Maillet M. Histopathologic findings in cutaneous cytomegalovirus infection. Am J Dermatopathol. 2000;22(5):397–407.

    CAS  PubMed  Google Scholar 

  32. Ryan C, De Gascun CF, Powell C, Sheahan K, Mooney EE, McCormick A, et al. Cytomegalovirus-induced cutaneous vasculopathy and perianal ulceration. J Am Acad Dermatol. 2011;64(6):1216–8.

    PubMed  Google Scholar 

  33. Chetty R, Bramdev A, Govender D. Cytomegalovirus-induced syringosquamous metaplasia. Am J Dermatopathol. 1999;21(5):487–90.

    CAS  PubMed  Google Scholar 

  34. Lin H-Y, Linn G, Liu C-B, Chen C-J, Yu K-J. An immunocompromised woman with severe molluscum contagiosum that responded well to topical imiquimod: a case report and literature review. J Low Genit Tract Dis. 2010;14(2):134–5.

    PubMed  Google Scholar 

  35. Palit A, Inamadar AC. Papulonodular genital growths in an HIV-infected woman. Clin Infect Dis. 2004;38(11):1585, 1633–4.

    PubMed  Google Scholar 

  36. Fischer GO. Vulval disease in pre-pubertal girls. Australas J Dermatol. 2001;42(4):225–34; quiz, 235–6.

    CAS  PubMed  Google Scholar 

  37. Berger EM, Orlow SJ, Patel RR, Schaffer JV. Experience with molluscum contagiosum and associated inflammatory reactions in a pediatric dermatology practice: the bump that rashes. Arch Dermatol. 2012;148(11):1257–64.

    CAS  PubMed  Google Scholar 

  38. Hošnjak L, Kocjan BJ, Kušar B, Seme K, Poljak M. Rapid detection and typing of molluscum contagiosum virus by FRET-based real-time PCR. J Virol Methods. 2013;187(2):431–4.

    PubMed  Google Scholar 

  39. Fathi R, Tsoukas MM. Genital warts and other HPV infections: established and novel therapies. Clin Dermatol. 2014;32(2):299–306.

    PubMed  Google Scholar 

  40. Nuovo GJ, Friedman D, Richart RM. In situ hybridization analysis of human papillomavirus DNA segregation patterns in lesions of the female genital tract. Gynecol Oncol. 1990;36(2):256–62.

    CAS  PubMed  Google Scholar 

  41. Stanley M. Pathology and epidemiology of HPV infection in females. Gynecol Oncol. 2010;117 (2 Suppl):S5–10.

    PubMed  Google Scholar 

  42. Roden RB, Lowy DR, Schiller JT. Papillomavirus is resistant to desiccation. J Infect Dis. 1997;176(4): 1076–9.

    CAS  PubMed  Google Scholar 

  43. de Koning MNC, ter Schegget J, Eekhof JAH, Kamp M, Kleter B, Gussekloo J, et al. Evaluation of a novel broad-spectrum PCR-multiplex genotyping assay for identification of cutaneous wart-associated human papillomavirus types. J Clin Microbiol. 2010; 48(5):1706–11.

    PubMed Central  PubMed  Google Scholar 

  44. Chiasson MA, Ellerbrock TV, Bush TJ, Sun XW, Wright TC. Increased prevalence of vulvovaginal condyloma and vulvar intraepithelial neoplasia in women infected with the human immunodeficiency virus. Obstet Gynecol. 1997;89(5 Pt 1):690–4.

    CAS  PubMed  Google Scholar 

  45. Marshburn PB, Trofatter KF. Recurrent condyloma acuminatum in women over age 40: association with immunosuppression and malignant disease. Am J Obstet Gynecol. 1988;159(2):429–33.

    CAS  PubMed  Google Scholar 

  46. Aguilera-Barrantes I, Magro C, Nuovo GJ. Verruca vulgaris of the vulva in children and adults: a nonvenereal type of vulvar wart. Am J Surg Pathol. 2007; 31(4):529–35.

    PubMed  Google Scholar 

  47. Sonnex C, Strauss S, Gray JJ. Detection of human papillomavirus DNA on the fingers of patients with genital warts. Sex Transm Infect. 1999;75(5): 317–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  48. Nucci MR, Genest DR, Tate JE, Sparks CK, Crum CP. Pseudobowenoid change of the vulva: a histologic variant of untreated condylata acuminatum. Mod Pathol. 1996;9(4):375–9.

    CAS  PubMed  Google Scholar 

  49. Zappacosta R, Colasante A, Viola P, D’Antuono T, Lattanzio G, Capanna S, et al. Chromogenic in situ hybridization and p16/Ki67 dual staining on formalin-fixed paraffin-embedded cervical specimens: correlation with HPV-DNA test, E6/E7 mRNA test, and potential clinical applications. Biomed Res Int. 2013;2013:453606.

    PubMed Central  PubMed  Google Scholar 

  50. Moyal-Barracco M, Leibowitch M, Orth G. Vestibular papillae of the vulva. Lack of evidence for human papillomavirus etiology. Arch Dermatol. 1990;126(12):1594–8.

    CAS  PubMed  Google Scholar 

  51. Konig A, Wennemuth G, Soyer HP, Hoffmann R, Happle R, Krause W. Vulvar amyloidosis mimicking giant condylomata acuminata in a patient with multiple myeloma. Eur J Dermatol. 1999;9(1):29–31.

    CAS  PubMed  Google Scholar 

  52. Schiera A, Pini M, Pioltelli P, Rossi E, Valente MG, Crippa D. Perianal condyloma-like lesions in multiple myeloma associated amyloidosis. Eur J Dermatol. 2004;14(3):193–5.

    PubMed  Google Scholar 

  53. Halvorsen JA, Brevig T, Aas T, Skar AG, Slevolden EM, Moi H. Genital ulcers as initial manifestation of Epstein-Barr virus infection: two new cases and a review of the literature. Acta Derm Venereol. 2006; 86(5):439–42.

    PubMed  Google Scholar 

  54. Barnes CJ, Alió AB, Cunningham BB, Friedlander SF. Epstein-Barr virus-associated genital ulcers: an under-recognized disorder. Pediatr Dermatol. 2007; 24(2):130–4.

    PubMed  Google Scholar 

  55. Aroutcheva AA, Simoes JA, Behbakht K, Faro S. Gardnerella vaginalis isolated from patients with bacterial vaginosis and from patients with healthy vaginal ecosystems. Clin Infect Dis. 2001;33(7): 1022–7.

    CAS  PubMed  Google Scholar 

  56. Udayalaxmi J, Bhat GK, Kotigadde S. Biotypes and virulence factors of Gardnerella vaginalis isolated from cases of bacterial vaginosis. Indian J Med Microbiol. 2011;29(2):165–8.

    CAS  PubMed  Google Scholar 

  57. Modak T, Arora P, Agnes C, Ray R, Goswami S, Ghosh P, et al. Diagnosis of bacterial vaginosis in cases of abnormal vaginal discharge: comparison of clinical and microbiological criteria. J Infect Dev Ctries. 2011;5(5):353–60.

    PubMed  Google Scholar 

  58. Bleker OP, Smalbraak DJ, Schutte MF. Bartholin’s abscess: the role of Chlamydia trachomatis. Genitourin Med. 1990;66(1):24–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  59. Bora SA, Condous G. Bartholin’s, vulval and perineal abscesses. Best Pract Res Clin Obstet Gynaecol. 2009;23(5):661–6.

    PubMed  Google Scholar 

  60. Pinsky BA, Baron EJ, Janda JM, Banaei N. Bartholin’s abscess caused by hypermucoviscous Klebsiella pneumoniae. J Med Microbiol. 2009;58 (Pt 5):671–3.

    PubMed  Google Scholar 

  61. Rees E. Gonococcal bartholinitis. Br J Vener Dis. 1967;43(3):150–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  62. Eady EA, Cove JH. Staphylococcal resistance revisited: community-acquired methicillin resistant Staphylococcus aureus–an emerging problem for the management of skin and soft tissue infections. Curr Opin Infect Dis. 2003;16(2):103–24.

    CAS  PubMed  Google Scholar 

  63. Kilpatrick CC, Alagkiozidis I, Orejuela FJ, Chohan L, Hollier LM. Factors complicating surgical management of the vulvar abscess. J Reprod Med. 2010; 55(3–4):139–42.

    PubMed  Google Scholar 

  64. Reichman O, Sobel JD. MRSA infection of buttocks, vulva, and genital tract in women. Curr Infect Dis Rep. 2009;11(6):465–70.

    PubMed  Google Scholar 

  65. Cabrera H, Skoczdopole L, Marini M, Giovanna Della P, Saponaro A, Echeverría C. Necrotizing gangrene of the genitalia and perineum. Int J Dermatol. 2002;41(12):847–51.

    PubMed  Google Scholar 

  66. Martinelli G, Alessandrino EP, Bernasconi P, Caldera D, Colombo A, Malcovati L, et al. Fournier’s gangrene: a clinical presentation of necrotizing fasciitis after bone marrow transplantation. Bone Marrow Transpl. 1998;22(10):1023–6.

    CAS  Google Scholar 

  67. Kroshinsky D, Alloo A, Rothschild B, Cummins J, Tan J, Montecino R, et al. Necrotizing Sweet syndrome: a new variant of neutrophilic dermatosis mimicking necrotizing fasciitis. J Am Acad Dermatol. 2012;67(5):945–54.

    PubMed  Google Scholar 

  68. Peeling RW, Hook EW. The pathogenesis of syphilis: the Great Mimicker, revisited. J Pathol. 2006; 208(2):224–32.

    CAS  PubMed  Google Scholar 

  69. Avenel G, Goëb V, Abboud P, Ait-Abdesselam T, Vittecoq O. Atypical forms of syphilis: two cases. Joint Bone Spine. 2009;76(3):293–5.

    PubMed  Google Scholar 

  70. Schnirring-Judge M, Gustaferro C, Terol C. Vesiculobullous syphilis: a case involving an unusual cutaneous manifestation of secondary syphilis. J Foot Ankle Surg. 2011;50(1):96–101.

    PubMed  Google Scholar 

  71. Pournaras CC, Masouyé I, Piletta P, Piguet V, Saurat J-H, French LE. Extensive annular verrucous late secondary syphilis. Br J Dermatol. 2005;152(6):1343–5.

    CAS  PubMed  Google Scholar 

  72. Buffet M, Grange PA, Gerhardt P, Carlotti A, Calvez V, Bianchi A, et al. Diagnosing Treponema pallidum in secondary syphilis by PCR and immunohistochemistry. J Invest Dermatol. 2007;127(10):2345–50.

    CAS  PubMed  Google Scholar 

  73. Jethwa HS, Schmitz JL, Dallabetta G, Behets F, Hoffman I, Hamilton H, et al. Comparison of molecular and microscopic techniques for detection of Treponema pallidum in genital ulcers. J Clin Microbiol. 1995;33(1):180–3.

    CAS  PubMed Central  PubMed  Google Scholar 

  74. Don PC, Rubinstein R, Christie S. Malignant syphilis (lues maligna) and concurrent infection with HIV. Int J Dermatol. 1995;34(6):403–7.

    CAS  PubMed  Google Scholar 

  75. Liotta EA, Turiansky GW, Berberian BJ, Sulica VI, Tomaszewski MM. Unusual presentation of secondary syphilis in 2 HIV-1 positive patients. Cutis. 2000;66(5):383–6, 389.

    CAS  PubMed  Google Scholar 

  76. Carlson JA, Dabiri G, Cribier B, Sell S. The immunopathobiology of syphilis: the manifestations and course of syphilis are determined by the level of delayed-type hypersensitivity. Am J Dermatopathol. 2011;33(5):433–60.

    PubMed Central  PubMed  Google Scholar 

  77. Zinkernagel RM. Antiinfection immunity and autoimmunity. Ann N Y Acad Sci. 2002;958:3–6.

    PubMed  Google Scholar 

  78. Smith G, Holman RP. The prozone phenomenon with syphilis and HIV-1 co-infection. South Med J. 2004;97(4):379–82.

    PubMed  Google Scholar 

  79. Hoang MP, High WA, Molberg KH. Secondary syphilis: a histologic and immunohistochemical evaluation. J Cutan Pathol. 2004;31(9):595–9.

    PubMed  Google Scholar 

  80. Jeerapaet P, Ackerman AB. Histologic patterns of secondary syphilis. Arch Dermatol. 1973;107(3):373–7.

    CAS  PubMed  Google Scholar 

  81. Martín-Ezquerra G, Fernandez-Casado A, Barco D, Jucglà A, Juanpere-Rodero N, Manresa JM, et al. Treponema pallidum distribution patterns in mucocutaneous lesions of primary and secondary syphilis: an immunohistochemical and ultrastructural study. Hum Pathol. 2009;40(5):624–30.

    PubMed  Google Scholar 

  82. Gayet-Ageron A, Ninet B, Toutous-Trellu L, Lautenschlager S, Furrer H, Piguet V, et al. Assessment of a real-time PCR test to diagnose syphilis from diverse biological samples. Sex Transm Infect. 2009;85(4): 264–9.

    CAS  PubMed  Google Scholar 

  83. Kouznetsov AV, Prinz JC. Molecular diagnosis of syphilis: the Schaudinn-Hoffmann lymph-node biopsy. Lancet. 2002;360(9330):388–9.

    CAS  PubMed  Google Scholar 

  84. Wenhai L, Jianzhong Z, Cao Y. Detection of Treponema pallidum in skin lesions of secondary syphilis and characterization of the inflammatory infiltrate. Dermatology. 2004;208(2):94–7.

    PubMed  Google Scholar 

  85. Chudomirova K, Chapkanov A, Abadjieva T, Popov S. Gummatous cutaneous syphilis. Sex Transm Dis. 2009;36(4):239–40.

    PubMed  Google Scholar 

  86. Centers for Disease Control and Prevention. Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae–2014. MMWR Recomm Rep. 2014;63 (RR-02):1–19.

    Google Scholar 

  87. Mohammed TT, Olumide YM. Chancroid and human immunodeficiency virus infection–a review. Int J Dermatol. 2008;47(1):1–8.

    PubMed  Google Scholar 

  88. Trees DL, Morse SA. Chancroid and Haemophilus ducreyi: an update. Clin Microbiol Rev. 1995;8(3): 357–75.

    CAS  PubMed Central  PubMed  Google Scholar 

  89. Janowicz DM, Tenner-Racz K, Racz P, Humphreys TL, Schnizlein-Bick C, Fortney KR, et al. Experimental infection with Haemophilus ducreyi in persons who are infected with HIV does not cause local or augment systemic viral replication. J Infect Dis. 2007; 195(10):1443–51.

    CAS  PubMed Central  PubMed  Google Scholar 

  90. Freinkel AL. Histological aspects of sexually transmitted genital lesions. Histopathology. 1987;11(8): 819–31.

    CAS  PubMed  Google Scholar 

  91. Abeck D, Freinkel AL, Korting HC, Szeimis RM, Ballard RC. Immunohistochemical investigations of genital ulcers caused by Haemophilus ducreyi. Int J STD AIDS. 1997;8(9):585–8.

    CAS  PubMed  Google Scholar 

  92. Schachter J. Chlamydial infections (third of three parts). N Engl J Med. 1978;298(10):540–9.

    CAS  PubMed  Google Scholar 

  93. Schachter J, Osoba AO. Lymphogranuloma venereum. Br Med Bull. 1983;39(2):151–4.

    CAS  PubMed  Google Scholar 

  94. Wu JJ, Huang DB, Pang KR, Tyring SK. Selected sexually transmitted diseases and their relationship to HIV. Clin Dermatol. 2004;22(6):499–508.

    PubMed  Google Scholar 

  95. Tchernev G, Salaro C, Costa MC, Patterson JW, Nenoff P. Lymphogranuloma venereum: “a clinical and histopathological chameleon?”. An Bras Dermatol. 2010;85(4):525–30.

    PubMed  Google Scholar 

  96. Joseph AK, Rosen T. Laboratory techniques used in the diagnosis of chancroid, granuloma inguinale, and lymphogranuloma venereum. Dermatol Clin. 1994;12(1):1–8.

    CAS  PubMed  Google Scholar 

  97. O’Farrell N. Donovanosis. Sex Transm Infect. 2002;78(6):452–7.

    PubMed Central  PubMed  Google Scholar 

  98. Sardana K, Garg VK, Arora P, Khurana N. Malignant transformation of donovanosis (granuloma inguinale) in a HIV-positive patient. Dermatol Online J. 2008;14(9):8.

    PubMed  Google Scholar 

  99. Carter JS, Bowden FJ, Bastian I, Myers GM, Sriprakash KS, Kemp DJ. Phylogenetic evidence for reclassification of Calymmatobacterium granulomatis as Klebsiella granulomatis comb. nov. Int J Syst Bacteriol. 1999;49 Pt 4:1695–700.

    CAS  PubMed  Google Scholar 

  100. Stoler MH, Bonfiglio TA, Steigbigel RT, Pereira M. An atypical subcutaneous infection associated with acquired immune deficiency syndrome. Am J Clin Pathol. 1983;80(5):714–8.

    CAS  PubMed  Google Scholar 

  101. Tappero JW, Mohle-Boetani J, Koehler JE, Swaminathan B, Berger TG, LeBoit PE, et al. The epidemiology of bacillary angiomatosis and bacillary peliosis. JAMA. 1993;269(6):770–5.

    CAS  PubMed  Google Scholar 

  102. Ramdial PK, Sing Y, Ramburan A, Dlova NC, Bagratee JS, Calonje E. Bartonella quintana-induced vulval bacillary angiomatosis. Int J Gynecol Pathol. 2012;31(4):390–4.

    PubMed  Google Scholar 

  103. Long SR, Whitfeld MJ, Eades C, Koehler JE, Korn AP, Zaloudek CJ. Bacillary angiomatosis of the cervix and vulva in a patient with AIDS. Obstet Gynecol. 1996;88(4 Pt 2):709–11.

    CAS  PubMed  Google Scholar 

  104. Shen H-P, Chang W-C, Hsieh C-H, Yang T-C, Hung Y-C. Vulvar tuberculosis. Taiwan J Obstet Gynecol. 2011;50(1):106–8.

    PubMed  Google Scholar 

  105. Dhall K, Das SS, Dey P. Tuberculosis of Bartholin’s gland. Int J Gynaecol Obstet. 1995;48(2):223–4.

    CAS  PubMed  Google Scholar 

  106. Brenner BN. Tuberculosis of the vulva: case reports. S Afr Med J. 1976;50(44):1798–800.

    CAS  PubMed  Google Scholar 

  107. Amin I, Idrees M, Awan Z, Shahid M, Afzal S, Hussain A. PCR could be a method of choice for identification of both pulmonary and extra-pulmonary tuberculosis. BMC Res Notes. 2011; 4:332.

    PubMed Central  PubMed  Google Scholar 

  108. Buppasiri P, Temtanakitpaisan T, Somboonporn W. Tuberculosis at vulva and vagina. J Med Assoc Thai. 2010;93(5):613–5.

    PubMed  Google Scholar 

  109. Manoj K, Soma M, Ajay L, Ashish A, Rakesh S, Paliwal RV. Tubercular sinus of labia majora: rare case report. Infect Dis Obstet Gynecol. 2008;2008: 817515.

    PubMed Central  PubMed  Google Scholar 

  110. Naik RP, Srinivas CR, Balachandran C, Narayan PK, Ramnarayan K, Sahoo RC. Esthiomene resulting from cutaneous tuberculosis of external genitalia. Genitourin Med. 1987;63(2):133–4.

    CAS  PubMed Central  PubMed  Google Scholar 

  111. Mendiratta V, Harjai B, Sardana K. Tubercular lymphadenitis with lymphangiectases of the vulva. J Eur Acad Dermatol Venereol. 2005;19(2): 264–5.

    CAS  PubMed  Google Scholar 

  112. Talwar A, Puri N, Sandhu HPS. Vulval lymphoedema following pulmonary tuberculosis. Int J STD AIDS. 2009;20(6):437–9.

    CAS  PubMed  Google Scholar 

  113. Wong S, Rizvi H, Cerio R, O’Toole EA. An unusual case of vulval papulonecrotic tuberculid. Clin Exp Dermatol. 2010;36(3):277–80.

    PubMed  Google Scholar 

  114. Pandhi D, Mehta S, Singal A. Genital tuberculid in a female child: a new entity (childhood vulval tuberculid). Pediatr Dermatol. 2007;24(5):573–5.

    PubMed  Google Scholar 

  115. Bhat RM, Saldanha CS, Kambil SM, Dandakeri S. Cutaneous lymphangiectasia of the vulva secondary to tuberculosis. Indian J Sex Transm Dis. 2012; 33(1):35–7.

    PubMed Central  PubMed  Google Scholar 

  116. Achkar JM, Fries BC. Candida infections of the genitourinary tract. Clin Microbiol Rev. 2010;23(2): 253–73.

    PubMed Central  PubMed  Google Scholar 

  117. Jacobsen MD, Duncan AD, Bain J, Johnson EM, Naglik JR, Shaw DJ, et al. Mixed Candida albicans strain populations in colonized and infected mucosal tissues. FEMS Yeast Res. 2008;8(8):1334–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  118. Fischer G. Chronic vulvovaginal candidiasis: what we know and what we have yet to learn. Australas J Dermatol. 2012;53(4):247–54.

    PubMed  Google Scholar 

  119. Goswami R, Dadhwal V, Tejaswi S, Datta K, Paul A, Haricharan RN, et al. Species-specific prevalence of vaginal candidiasis among patients with diabetes mellitus and its relation to their glycaemic status. J Infect. 2000;41(2):162–6.

    CAS  PubMed  Google Scholar 

  120. Sobel JD. Vulvovaginal candidosis. Lancet. 2007; 369(9577):1961–71.

    PubMed  Google Scholar 

  121. McClelland RS, Richardson BA, Hassan WM, Graham SM, Kiarie J, Baeten JM, et al. Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasis. J Infect Dis. 2009; 199(12):1883–90.

    PubMed Central  PubMed  Google Scholar 

  122. Foxman B, Muraglia R, Dietz J-P, Sobel JD, Wagner J. Prevalence of recurrent vulvovaginal candidiasis in 5 European countries and the United States: results from an internet panel survey. J Low Genit Tract Dis. 2013;17(3):340–5.

    PubMed  Google Scholar 

  123. Mayser P, Schütz M, Schuppe HC, Jung A, Schill WB. Frequency and spectrum of Malassezia yeasts in the area of the prepuce and glans penis. BJU Int. 2001;88(6):554–8.

    CAS  PubMed  Google Scholar 

  124. Day T, Scurry J. Vulvar pityriasis versicolor in an immunocompetent woman. J Low Genit Tract Dis. 2014 Jul;18(3):e71–3.

    Google Scholar 

  125. Nyirjesy P, Nixon JM, Jordan CA, Buckley HR. Malassezia furfur folliculitis of the vulva: olive oil solves the mystery. Obstet Gynecol. 1994;84 (4 Pt 2):710–1.

    CAS  PubMed  Google Scholar 

  126. Chang SE, Lee DK, Choi JH, Moon KC, Koh JK. Majocchi’s granuloma of the vulva caused by Trichophyton mentagrophytes. Mycoses. 2005; 48(6):382–4.

    CAS  PubMed  Google Scholar 

  127. Galvin SR, Cohen MS. The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol. 2004;2(1):33–42.

    CAS  PubMed  Google Scholar 

  128. Vasoo S, Pritt BS. Molecular diagnostics and parasitic disease. Clin Lab Med. 2013;33(3):461–503.

    PubMed  Google Scholar 

  129. Petrin D, Delgaty K, Bhatt R, Garber G. Clinical and microbiological aspects of Trichomonas vaginalis. Clin Microbiol Rev. 1998;11(2):300–17.

    CAS  PubMed Central  PubMed  Google Scholar 

  130. Mounsey KE, McCarthy JS, Walton SF. Scratching the itch: new tools to advance understanding of scabies. Trends Parasitol. 2013;29(1):35–42.

    PubMed  Google Scholar 

  131. Foo CW, Florell SR, Bowen AR. Polarizable elements in scabies infestation: a clue to diagnosis. J Cutan Pathol. 2013;40(1):6–10.

    PubMed  Google Scholar 

  132. Bakos L, Reusch MC, D’Elia P, Aquino V, Bakos RM. Crusted scabies of the vulva. J Eur Acad Dermatol Venereol. 2007;21(5):682–4.

    CAS  PubMed  Google Scholar 

  133. Kempf W. CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators. J Cutan Pathol. 2006;33(S1): 58–70.

    PubMed  Google Scholar 

  134. Bhattacharjee P, Glusac EJ. Langerhans cell hyperplasia in scabies: a mimic of Langerhans cell histiocytosis. J Cutan Pathol. 2007;34(9):716–20.

    PubMed  Google Scholar 

  135. Burch JM. Sarcoptes scabiei infestation misdiagnosed and treated as Langerhans cell histiocytosis. Pediatr Dermatol. 2004;21:58–62.

    Google Scholar 

  136. Anderson AL, Chaney E. Pubic lice (Pthirus pubis): history, biology and treatment vs. knowledge and beliefs of US college students. Int J Environ Res Public Health. 2009;6(2):592–600.

    PubMed Central  PubMed  Google Scholar 

  137. Leone PA. Scabies and pediculosis pubis: an update of treatment regimens and general review. Clin Infect Dis. 2007;44 Suppl 3:S153–9.

    PubMed  Google Scholar 

  138. Kazlouskaya V, Lambe J, Elston D. Solitary epidermolytic acanthoma. J Cutan Pathol. 2013;40(8): 701–7.

    PubMed  Google Scholar 

  139. Quinn TR, Young RH. Epidermolytic hyperkeratosis in the lower female genital tract: an uncommon simulant of mucocutaneous papillomavirus infection–a report of two cases. Int J Gynecol Pathol. 1997; 16(2):163–8.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Duke University Medical Center, Durham, NC, USA

    Maria Angelica Selim M.D.

  2. Facultad de Ciencias Medicas Uncuyo, Hospital Luis Lagomaggioer, Mendoza, Argentina

    Viviana Parra M.D.

  3. Departments of Pathology and Dermatology, Wake Forest Baptist Medical Center, Wake Forest University School of Medicine, Winston Salem, NC, USA

    Omar P. Sangueza M.D.

  4. Fundacion Jimenez Diaz, Madrid, Spain

    Luis Requena M.D.

  5. Department of Pathology, Caja Nacional de Salud, La Paz, Bolivia

    Martin A. Sangueza M.D.

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  1. Maria Angelica Selim M.D.
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  2. Viviana Parra M.D.
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  3. Omar P. Sangueza M.D.
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  4. Luis Requena M.D.
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  5. Martin A. Sangueza M.D.
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Correspondence to Maria Angelica Selim M.D. .

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Editors and Affiliations

  1. Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Mai P. Hoang

  2. Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA

    Maria Angelica Selim

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Selim, M.A., Parra, V., Sangueza, O.P., Requena, L., Sangueza, M.A. (2015). Infectious Diseases and Infestations of the Vulva. In: Hoang, M., Selim, M. (eds) Vulvar Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1807-2_6

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  • DOI: https://doi.org/10.1007/978-1-4939-1807-2_6

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