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Inflammatory Disorders Affecting the Epidermis of the Vulva

  • Russell A. Ball
  • Libby Edwards
  • Jason C. Reutter
  • Kelly L. West
  • Maria Angelica SelimEmail author
Chapter

Abstract

Inflammatory dermatoses involving the epidermis are a prevalent cause of biopsy of the vulva. Herein, we describe the most common pathologic processes involving the vulvar epidermis including the spongiotic pattern (allergic contact dermatitis, irritant contact dermatitis, amicrobial pustulosis of the folds), cytotoxic or vacuolar interface pattern (fixed drug eruption, erythema multiforme, Stevens-Johnson syndrome/toxic epidermal necrolysis, graft-versus-host disease, lupus erythematosus), and acanthotic pattern (lichen simplex chronicus, psoriasis and Reiter’s syndrome). The salient histologic features, differential diagnoses and the challenges encountered by the reviewing pathologist will be emphasized.

Keywords

Contact dermatitis Psoriasis Reiter’s Lupus erythematosus Drug eruption Lichen simplex chronicus Erythema multiforme Toxic epidermal necrolysis 

Abbreviations

ACD

Allergic contact dermatitis

APF

Amicrobial pustulosis of the folds

DLE

Discoid lupus erythematous

EM

Erythema multiforme

GVHD

Graft-versus-host disease

HSV

Herpes simplex virus

ICD

Irritant contact dermatitis

LE

Lupus erythematous

LSC

Lichen simplex chronicus

PEH

Pseudoepitheliomatous hyperplasia

SJS

Stevens-Johnson syndrome

SLE

Systemic lupus erythematous

TEN

Toxic epidermal necrolysis

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Russell A. Ball
    • 1
  • Libby Edwards
    • 2
  • Jason C. Reutter
    • 3
  • Kelly L. West
    • 1
  • Maria Angelica Selim
    • 4
    Email author
  1. 1.Ball DermpathGreensboroUSA
  2. 2.Department of Internal MedicineCarolinas Medical CenterCharlotteUSA
  3. 3.Department of DermatopathologyPiedmont Pathology AssociatesHickoryUSA
  4. 4.Department of PathologyDuke University Medical CenterDurhamUSA

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