Optical Coherence Tomography of Malignancies of the Head and Neck

  • Giriraj K. Sharma
  • Marc Rubinstein
  • Christian Betz
  • Brian J.-F. Wong


Optical coherence tomography (OCT) is a minimally invasive optical imaging modality which produces high-resolution, three-dimensional (3D) images of biological tissue. In the last 10 years, biophotonics and optics research have led to the advancement of OCT technology and expansion of OCT applications within Otorhinolaryngology—Head and Neck Surgery. In vivo clinical studies have demonstrated the potential for OCT to perform minimally invasive diagnostic imaging and differentiation of premalignant and malignant lesions of the head and neck. This chapter reviews the research and clinical applications for OCT imaging of malignancy in the upper aerodigestive tract.


Optical coherence tomography Cancer Precancerous Dysplasia Upper aerodigestive tract Oral cavity Pharynx Larynx 


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Giriraj K. Sharma
    • 1
  • Marc Rubinstein
    • 2
  • Christian Betz
    • 4
  • Brian J.-F. Wong
    • 3
  1. 1.Department of Otolaryngology—Head and Neck SurgeryUC Irvine Medical CenterOrangeUSA
  2. 2.The Beckman Laser Institute, Department of OtorhinolaryngologyKlinikum der Universität MünchenMunichGermany
  3. 3.The Beckman Laser Institute, Dept of Oto, MunichIrvineUSA
  4. 4.Department of OtorhinolaryngologMunich University HospitalMunichUSA

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