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Biomedical Optics in Otorhinolaryngology pp 529–543Cite as

Optical Coherence Tomography

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Abstract

Optical coherence tomography is a noninvasive optical imaging modality that is rapidly gaining adoption in many clinical applications. OCT is capable of providing high-speed three-dimensional cross-sectional views into biological tissues with micrometer-scale resolutions. In this chapter, we will review the physical principles behind OCT starting early time-domain-based systems and then discuss the development of more recent high-speed Fourier-domain OCT systems. We will then discuss clinical utilization of OCT via two functional developments: Doppler-based OCT for the quantification of particulate flow rates such as blood flow and optical coherence elastography for mapping of tissue mechanical properties. Finally, we will discuss the development of endoscopic-based OCT for in vivo imaging within internal lumens such as the human airway.

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Acknowledgment

We acknowledge grant support from the BEST IGERT program funded by the National Science Foundation DGE-1144901, the National Institutes of Health (R01EB-10090, R01EY-021519, R01HL-105215, R01HL-103764, P41EB-015890), the Air Force Office of Scientific Research (FA9550-10-1-0538), and the Beckman Laser Institute Endowment. Dr. Chen has a financial interest in OCT Medical Imaging, Inc., which, however, did not support this work.

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Authors and Affiliations

  1. The Beckman Laser Institute, University of California Irvine, Irvine, 92612, CA, USA

    Joseph Jing PhD & Zhongping Chen PhD

  2. Department of Biomedical Engineering, University of California Irvine, Irvine, CA, 92697, USA

    Joseph Jing PhD & Zhongping Chen PhD

Authors
  1. Joseph Jing PhD
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  2. Zhongping Chen PhD
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Correspondence to Zhongping Chen PhD .

Editor information

Editors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Department of Biomedical Engineering, Division of Facial Plastic Surgery, The Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California, USA

    Brian J.-F. Wong

  2. Department of Otorhinolaryngology, Plastic, Head and Neck Surgery, RWTH Aachen University Hospital, Aachen, Germany

    Justus Ilgner

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Jing, J., Chen, Z. (2016). Optical Coherence Tomography. In: Wong, BF., Ilgner, J. (eds) Biomedical Optics in Otorhinolaryngology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1758-7_32

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  • DOI: https://doi.org/10.1007/978-1-4939-1758-7_32

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1757-0

  • Online ISBN: 978-1-4939-1758-7

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