Skip to main content

Management of Irritable Bowel Syndrome in the Patient with Ulcerative Colitis

  • Chapter
  • First Online:
Medical Therapy of Ulcerative Colitis

Abstract

Irritable bowel syndrome (IBS) is one of the most common disorders in gastroenterology, affecting 10–15 % of the US population and accounting for one-quarter to one-half of all visits to digestive health specialists. With such a high prevalence, it may be inferred that a significant number of patients with ulcerative colitis (UC) also suffer from coexisting IBS. Indeed, it is widely believed that the prevalence of IBS is greater in patients with inflammatory bowel disease (IBD), affecting an estimated one-third of UC patients in remission. Recent research demonstrating a possible association between low-grade inflammation and IBS highlights the interconnecting relationship between inflammatory and functional disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Sandler RS, Drossman DA, Nathan HP, et al. Symptom complaints and health care seeking behavior in subjects with bowel dysfunction. Gastroenterology. 1984;87:314–8.

    CAS  PubMed  Google Scholar 

  2. Isgar B, Harman M, Kaye M, et al. Symptoms of irritable bowel syndrome in ulcerative colitis in remission. Gut. 1983;24:190–2.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Simrén M, Axelsson J, Gillberg R, Abrahamsson H, Svedlund J, Björnsson ES. Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors. Am J Gastroenterol. 2002;97(2):389–96.

    Article  PubMed  Google Scholar 

  4. Minderhoud IM, Oldenburg B, Wismeijer JA, van Berge Henegouwen GP, Smout AJ. IBS-like symptoms in patients with inflammatory bowel disease in remission; relationships with quality of life and coping behavior. Dig Dis Sci. 2004;49(3):469–74.

    Article  PubMed  Google Scholar 

  5. Keohane J, O’Mahony C, O’Mahony L, O’Mahony S, Quigley EM, Shanahan F. Irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease: a real association or reflection of occult inflammation? Am J Gastroenterol. 2010;105(8):1788. 1789-94; quiz 1795. doi: 10.1038/ajg.2010.156. Epub 2010 Apr 13.

    Article  PubMed  Google Scholar 

  6. Thompson WG, Heaton KW. Functional bowel disorders in apparently healthy people. Gastroenterology. 1980;79:283–8.

    CAS  PubMed  Google Scholar 

  7. Burgmann T, Clara I, Graff L, et al. The Manitoba Inflammatory Bowel Disease Cohort Study: prolonged symptoms after diagnosis—how much is irritable bowel syndrome? Clin Gastroenterol Hepatol. 2006;4:614–20.

    Article  PubMed  Google Scholar 

  8. Ansari R, Attari F, Razjouyan H, et al. Ulcerative colitis and irritable bowel syndrome: relationships with quality of life. Eur J Gastroenterol Hepatol. 2008;20:46–50.

    Article  PubMed  Google Scholar 

  9. Chang MH, Chou JW, Chen SM, Tsai MC, Sun YS, Lin CC, Lin CP. Faecal calprotectin as a novel biomarker for differentiating between inflammatory bowel disease and irritable bowel syndrome. Mol Med Rep. 2014;10(1):522–6.

    CAS  PubMed  Google Scholar 

  10. Geboes K, Collins S. Structural abnormalities of the nervous system in Crohn’s disease and ulcerative colitis. Neurogastroenterol Motil. 1998;10:189–202.

    Article  CAS  PubMed  Google Scholar 

  11. Shanahan F. Enteric neuropathology and inflammatory bowel disease. Neurogastroenterol Motil. 1998;10:185–7.

    Article  CAS  PubMed  Google Scholar 

  12. Collins SM. The immunomodulation of enteric neuromuscular function: implications for motility and inflammatory disorders. Gastroenterology. 1996;111:1683–99.

    Article  CAS  PubMed  Google Scholar 

  13. MacPherson BR, Shearon NL, Pfeiffer CJ. Experimental diffuse colitis in cats: observations on motor changes. J Surg Res. 1978;25:42–9.

    Article  CAS  PubMed  Google Scholar 

  14. Barbara G, Vallance BA, Collins SM. Persistent intestinal neuromuscular dysfunction after acute nematode infection in mice. Gastroenterology. 1997;113:1224–32.

    Article  CAS  PubMed  Google Scholar 

  15. Rao SS, Read NW. Gastrointestinal motility in patients with ulcerative colitis. Scand J Gastroenterol Suppl. 1990;172:22–8.

    Article  CAS  PubMed  Google Scholar 

  16. Farthing MJ, Lennard-Jones JE. Sensibility of the rectum to distension and the anorectal distension reflex in ulcerative colitis. Gut. 1978;19:64–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Manousos ON, Salem SN. Abnormal motility of the small intestine in ulcerative colitis. Gastroenterologia. 1965;104:249–57.

    Article  CAS  PubMed  Google Scholar 

  18. Ohman L, Simren M. Pathogenesis of IBS: role of inflammation, immunity, and neuroimmune interactions. Nat Rev Gastroenterol Hepatol. 2010;7:163–73.

    Article  PubMed  Google Scholar 

  19. Chaudhary NA, Truelove SC. The irritable colon syndrome. A study of the clinical features, predisposing causes, and prognosis in 130 cases. Q J Med. 1962;31:307–22.

    CAS  PubMed  Google Scholar 

  20. Drossman DA. Mind over matter in the postinfective irritable bowel. Gut. 1999;44:306–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Pimentel M, Lembo A, Chey WD, et al. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med. 2011;364:22–32.

    Article  CAS  PubMed  Google Scholar 

  22. Spiegel B. Questioning the bacterial overgrowth hypothesis in irritable bowel syndrome: an epidemiologic and evolutionary perspective. Clin Gastroenterol Hepatol. 2011;9:461–9.

    Article  PubMed  Google Scholar 

  23. Shanahan F, Quigley EM. Manipulation of the microbiota for treatment of IBS and IBD-challenges and controversies. Gastroenterology. 2014;146(6):1554–63.

    Article  PubMed  Google Scholar 

  24. Schmidt CM, Horton KM, Sitzmann JV, et al. Simple radiographic evaluation of ileoanal pouch volume. Dis Colon Rectum. 1996;39:66–73.

    Article  CAS  PubMed  Google Scholar 

  25. Bernstein CN, Rollandelli R, Niazi N, et al. Characterization of afferent mechanisms in ileoanal pouches. Am J Gastroenterol. 1997;92:103–8.

    CAS  PubMed  Google Scholar 

  26. Shen B, Achkar JP, Lashner BA, et al. Irritable pouch syndrome: a new category of diagnosis for symptomatic patients with ileal pouch-anal anastomosis. Am J Gastroenterol. 2002;97:972–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philip M. Ginsburg M.D., F.A.C.G. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ginsburg, P.M., Bayless, T.M. (2014). Management of Irritable Bowel Syndrome in the Patient with Ulcerative Colitis. In: Lichtenstein, G. (eds) Medical Therapy of Ulcerative Colitis. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1677-1_40

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-1677-1_40

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1676-4

  • Online ISBN: 978-1-4939-1677-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics