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Essential Imaging in Rheumatology pp 213–232Cite as

Crystal-Related Disease

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Abstract

Gout, a chronic recurrent systemic crystal depositional disease, is the commonest inflammatory arthritis in men over the age of 40 years. It affects 1 % of adults and up to 7 % of men over the age of 65 years. It is uncommon in premenopausal women and has a male to female ratio of 4:1 for primary gout. It is secondary to an inflammatory response incited by the deposition of monosodium urate crystals (MSU) in soft tissues, joint space and marrow. Aetiology can be divided into primary (90 %) and secondary (10 %), related to urate under-excretion or overproduction, respectively. Urate under-excretion pathologies include idiopathic, association with renal dysfunction and drugs including diuretics, ASA and cyclosporine. Urate overproduction includes increased cell turnover in myeloproliferative diseases, related to chemotherapy in treatment of malignancies and increased purine intake, e.g. alcohol.

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Further Reading

Gout

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Authors and Affiliations

  1. Musculoskeletal Imaging, Diagnostic Imaging, McMaster University/St Joseph’s Healthcare, Hamilton, ON, L8N4A6, Canada

    John O’Neill MB, BAO, BCh, MRCPI, MSc, FRCR (Associate Professor)

Authors
  1. John O’Neill MB, BAO, BCh, MRCPI, MSc, FRCR
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Correspondence to John O’Neill MB, BAO, BCh, MRCPI, MSc, FRCR .

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Editors and Affiliations

  1. Diagnostic Imaging, McMaster University/St Joseph's Healthcare, Hamilton, Ontario, Canada

    John O'Neill

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© 2015 Springer Science+Business Media New York

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O’Neill, J. (2015). Crystal-Related Disease. In: O'Neill, J. (eds) Essential Imaging in Rheumatology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1673-3_8

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  • DOI: https://doi.org/10.1007/978-1-4939-1673-3_8

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1672-6

  • Online ISBN: 978-1-4939-1673-3

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