Humanized Mice as Models for Human Disease
The optimization and standardization of humanized mouse models has been ongoing for many years now, with development of specific models that have unique applications for discovery research and preclinical analysis of antiviral drugs. In this review, we strive to place this continuum of work into perspective, both to provide an historical footing to its progress and to urge attention to obstacles that continue to confront the full application of these models to the analysis of human disease.
KeywordsHumanized mouse Immunodeficient mouse Human tissue Preclinical drug development HIV
We would like to thank Drs. Sandra Bridges, Cheryl Stoddart, and Jerry Zack for their careful reading of this manuscript as well as for their many contributions to humanized mouse technology.
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