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Mesoporous ASD: Fundamentals

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Amorphous Solid Dispersions

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

Mesoporous silica materials are having an impact in traditional pharmaceutical applications and nanomedicine. As excipients, they are allowing the enhancement of poorly soluble drugs with significant improvements in solubility for a large variety of type II drug compounds. Synthetic and structural versatility allows to truly design both mesopore structure and mesopore size with great precision promising to allow for a library of standard materials that can deliver tailored pharmacokinetic release profiles. In this chapter, we highlight some of the important developments in the field of mesoporous materials focusing on early synthetic aspects as well as later functionalisation strategies. The characterisation methods that are employed commonly and may be used to facilitate production and quality assessment are also discussed. Finally, we update the reader with some brief examples of how these non-toxic and biocompatible vehicles are entering pharmaceutical applications.

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Author information

Authors and Affiliations

  1. Department of Materials and Environmental Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, Sweden

    Alfonso Garcia-Bennett

  2. Nanologica AB, Stockholm, Sweden

    Adam Feiler

Authors
  1. Alfonso Garcia-Bennett
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  2. Adam Feiler
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Correspondence to Alfonso Garcia-Bennett .

Editor information

Editors and Affiliations

  1. Kashiv Pharmaceuticals, Bridgewater, New Jersey, USA

    Navnit Shah

  2. Merck & Co., Inc., Summit, New Jersey, USA

    Harpreet Sandhu

  3. Kashiv Pharmaceuticals, Bridgewater, New Jersey, USA

    Duk Soon Choi

  4. Pharmaceutical Research & Early Development, Roche Innovation Center, New York, New York, USA

    Hitesh Chokshi

  5. Pharmaceutical and Analytical R&D, Hoffmann-La Roche Ltd., Nutley, New Jersey, USA

    A. Waseem Malick

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Garcia-Bennett, A., Feiler, A. (2014). Mesoporous ASD: Fundamentals. In: Shah, N., Sandhu, H., Choi, D., Chokshi, H., Malick, A. (eds) Amorphous Solid Dispersions. Advances in Delivery Science and Technology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1598-9_22

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