Developmental Origins of Disease: The Role of Oxidative Stress

Part of the Oxidative Stress in Applied Basic Research and Clinical Practice book series (OXISTRESS)


The “thrifty phenotype” hypothesis proposes that the fetus adapts to an adverse intrauterine milieu by optimizing the use of a reduced nutrient supply to ensure survival, but by favoring the development of certain organs over that of others, this leads to persistent alterations in the growth and function of developing tissues. This concept has been somewhat controversial; however, recent epidemiological, clinical, and animal studies provide support for the developmental origins of disease hypothesis. Underlying mechanisms include reprogramming of the hypothalamic-pituitary-adrenal axis, islet development, and insulin signaling pathways. Emerging data suggests that oxidative stress and mitochondrial dysfunction may also play a critical role in the pathogenesis of type 2 diabetes in individuals who were growth retarded at birth.


Mitochondrial Dysfunction Fetal Growth Restriction Hepatic Glucose Production Fetal Growth Retardation Uterine Artery Ligation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Pediatrics Children’s Hospital PhiladelphiaUniversity of PennsylvaniaPhiladelphiaUSA

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