Modeling of Signal Transduction by the Quorum-Sensing Pathway in the Vibrios
Several bacterial species have regulatory networks that enable global alterations in gene expression in response to changes in local cell density. This process, commonly referred to as quorum sensing, typically leads to the regulation of cooperative processes such as bioluminescence and biofilm formation. Here, we provide an overview of the quorum-sensing network in the marine bacterium Vibrio harveyi and focus on studies based on theoretical modeling approaches. These studies have led to testable predictions for experiments that can further elucidate roles of pathway elements such as small RNAs in shaping and fine-tuning the quorum-sensing response to changes in cell density. Furthermore, single-cell analysis has provided new insights into information processing by the quorum sensing pathway and opened up new avenues for future research.
KeywordsHigh Cell Density Negative Feedback Loop Histidine Kinase Dosage Compensation Burst Size
AB is thankful to CSIR (09/015(0375)/2009-EMR-I) for research fellowship. SKB acknowledges support from Bose Institute through Institutional Programme VI—Development of Systems Biology. RVK would like to acknowledge funding support from the NSF through award PHY-0957430.
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