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Hyaluronic Acid: A Key Facilitator of Cancer Evolution

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Cancer Bioinformatics

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Abstract

Otto Warburg made a seminal speculation in the 1960s that the switch in cellular energy metabolism from aerobic respiration to glycolytic fermentation is the driving force for cancer development. While increasingly more cancer researchers tend to agree with Warburg, it remains unknown, even five decades after his hypothesis, how this switch is linked to cell proliferation. We have discussed in Chap. 5 how chronic hypoxia and mitochondrial ROS accumulation will lead to continual accumulation of glucose metabolites, possibly resulting in cell death if not removed. This buildup imposes a persistent pressure on the host cells to evolve in order to survive, and cell proliferation represents a most feasible way for these cells to remove the accumulation of metabolites in a sustained manner. We will discuss in this chapter how this pressure can trigger a cellular program to facilitate cell proliferation, hence providing an exit for the accumulated glucose metabolites and a pathway to survival through proliferation.

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References

  • Ã…gren UM, Tammi RH, Tammi MI (1997) Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ culture. Free Radical Biology and Medicine 23: 996–1001

    Google Scholar 

  • Ahrens T, Assmann V, Fieber C et al. (2001) CD44 is the principal mediator of hyaluronic-acid-induced melanoma cell proliferation. J Invest Dermatol 116: 93–101

    Google Scholar 

  • Alaniz L, Cabrera PV, Blanco G et al. (2002) Interaction of CD44 with Different Forms of Hyaluronic Acid. Its Role in Adhesion and Migration of Tumor Cells. Cell Communication and Adhesion 9: 117–130

    Google Scholar 

  • Alberts B, Johnson A, Lewis J et al. (2002) Molecular Biology of the Cell, 4th edition. Available from: http://www.ncbi.nlm.nih.gov/books/NBK26877/, Extracellular Control of Cell Division, Cell Growth, and Apoptosis.

  • Attia M, Huet E, Delbe J et al. (2011) Extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) as a novel regulator of myogenic cell differentiation. Journal of cellular physiology 226: 141–149

    Google Scholar 

  • Avery DT, Deenick EK, Ma CS et al. (2010) B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. The Journal of experimental medicine 207: 155–171

    Google Scholar 

  • Basu GD, Pathangey LB, Tinder TL et al. (2004) Cyclooxygenase-2 inhibitor induces apoptosis in breast cancer cells in an in vivo model of spontaneous metastatic breast cancer. Molecular cancer research : MCR 2: 632–642

    Google Scholar 

  • Bernanke DH, Markwald RR (1979) Effects of hyaluronic acid on cardiac cushion tissue cells in collagen matrix cultures. Texas reports on biology and medicine 39: 271–285

    Google Scholar 

  • Bernert B, Porsch H, Heldin P (2011) Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1). J Biol Chem 286: 42349–42359

    Google Scholar 

  • Bharadwaj AG, Kovar JL, Loughman E et al. (2009) Spontaneous metastasis of prostate cancer is promoted by excess hyaluronan synthesis and processing. The American journal of pathology 174: 1027–1036

    Google Scholar 

  • Bharadwaj AG, Rector K, Simpson MA (2007) Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis. J Biol Chem 282: 20561–20572

    Google Scholar 

  • Black KE, Collins SL, Hagan RS et al. (2013) Hyaluronan fragments induce IFNbeta via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway. Journal of inflammation 10: 23

    Google Scholar 

  • Bourguignon LY (2008) Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression. Seminars in cancer biology 18: 251–259

    Google Scholar 

  • Bourguignon LY, Gilad E, Rothman K et al. (2005) Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression. J Biol Chem 280: 11961–11972

    Google Scholar 

  • Bourguignon LY, Ramez M, Gilad E et al. (2006) Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis. J Invest Dermatol 126: 1356–1365

    Google Scholar 

  • Bourguignon LY, Spevak CC, Wong G et al. (2009) Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem 284: 26533–26546

    Google Scholar 

  • Bourguignon LY, Wong G, Earle CA et al. (2011) Interaction of low molecular weight hyaluronan with CD44 and toll-like receptors promotes the actin filament-associated protein 110-actin binding and MyD88-NFkappaB signaling leading to proinflammatory cytokine/chemokine production and breast tumor invasion. Cytoskeleton 68: 671–693

    Google Scholar 

  • Brown RL, Reinke LM, Damerow MS et al. (2011) CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. The Journal of clinical investigation 121: 1064–1074

    Google Scholar 

  • Budirahardja Y, Gonczy P (2009) Coupling the cell cycle to development. Development 136: 2861–2872

    Google Scholar 

  • Calame K (2008) Activation-dependent induction of Blimp-1. Current opinion in immunology 20: 259–264

    Google Scholar 

  • Clarkin CE, Allen S, Kuiper NJ et al. (2011) Regulation of UDP-glucose dehydrogenase is sufficient to modulate hyaluronan production and release, control sulfated GAG synthesis, and promote chondrogenesis. Journal of cellular physiology 226: 749–761

    Google Scholar 

  • Collins SL, Black KE, Chan-Li Y et al. (2011) Hyaluronan fragments promote inflammation by down-regulating the anti-inflammatory A2a receptor. Am J Respir Cell Mol Biol 45: 675–683

    Google Scholar 

  • Colotta F, Allavena P, Sica A et al. (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30: 1073–1081

    Google Scholar 

  • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860–867

    Google Scholar 

  • Croft DR, Olson MF (2006) The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Molecular and cellular biology 26: 4612–4627

    Google Scholar 

  • Csoka AB, Stern R (2013) Hypotheses on the evolution of hyaluronan: a highly ironic acid. Glycobiology 23: 398–411

    Google Scholar 

  • Dai C, Whitesell L, Rogers AB et al. (2007) Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130: 1005–1018

    Google Scholar 

  • Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes & development 13: 2905–2927

    Google Scholar 

  • Delmage JM, Powars DR, Jaynes PK et al. (1986) The selective suppression of immunogenicity by hyaluronic acid. Ann Clin Lab Sci 16: 303–310

    Google Scholar 

  • Diehl SA, Schmidlin H, Nagasawa M et al. (2008) STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. Journal of immunology 180: 4805–4815

    Google Scholar 

  • Ding XZ, Tong WG, Adrian TE (2000) Blockade of cyclooxygenase-2 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Anticancer research 20: 2625–2631

    Google Scholar 

  • Drubin DG, Nelson WJ (1996) Origins of cell polarity. Cell 84: 335–344

    Google Scholar 

  • Duan J, Kasper DL (2011) Oxidative depolymerization of polysaccharides by reactive oxygen/nitrogen species. Glycobiology 21: 401–409

    Google Scholar 

  • Erickson M, Stern R (2012) Chain gangs: new aspects of hyaluronan metabolism. Biochem Res Int 2012: 893947

    Google Scholar 

  • Evanko SP, Angello JC, Wight TN (1999) Formation of hyaluronan- and versican-rich pericellular matrix is required for proliferation and migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 19: 1004–1013

    Google Scholar 

  • Fantus IG, Goldberg H, Whiteside C et al. (2006) The Hexosamine Biosynthesis Pathway. In: Cortes P, Mogensen C (eds) The Diabetic Kidney. Contemporary Diabetes. Humana Press, pp 117–133

    Google Scholar 

  • Fieber C, Baumann P, Vallon R et al. (2004) Hyaluronan-oligosaccharide-induced transcription of metalloproteases. Journal of cell science 117: 359–367

    Google Scholar 

  • Ghatak S, Misra S, Toole BP (2002) Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. J Biol Chem 277: 38013–38020

    Google Scholar 

  • Guillaumond F, Leca J, Olivares O et al. (2013) Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America 110: 3919–3924

    Google Scholar 

  • Guo H, Li R, Zucker S et al. (2000) EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface. Cancer research 60: 888–891

    Google Scholar 

  • Gururaj A, Barnes CJ, Vadlamudi RK et al. (2004) Regulation of phosphoglucomutase 1 phosphorylation and activity by a signaling kinase. Oncogene 23: 8118–8127

    Google Scholar 

  • Hall CL, Turley EA (1995) Hyaluronan: RHAMM mediated cell locomotion and signaling in tumorigenesis. Journal of neuro-oncology 26: 221–229

    Google Scholar 

  • Hall CL, Wang C, Lange LA et al. (1994) Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. The Journal of cell biology 126: 575–588

    Google Scholar 

  • Hamann KJ, Dowling TL, Neeley SP et al. (1995) Hyaluronic acid enhances cell proliferation during eosinopoiesis through the CD44 surface antigen. Journal of immunology 154: 4073–4080

    Google Scholar 

  • Hamilton SR, Fard SF, Paiwand FF et al. (2007) The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem 282: 16667–16680

    Google Scholar 

  • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100: 57–70

    Google Scholar 

  • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646–674

    Google Scholar 

  • Haylock DN, Nilsson SK (2006) The role of hyaluronic acid in hemopoietic stem cell biology. Regen Med 1: 437–445

    Google Scholar 

  • Heise RL, Stober V, Cheluvaraju C et al. (2011) Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem 286: 17435–17444

    Google Scholar 

  • Heldin P (2003) Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica [et al] 36: 967–973

    Google Scholar 

  • Holmes MW, Bayliss MT, Muir H (1988) Hyaluronic acid in human articular cartilage. Age-related changes in content and size. The Biochemical journal 250: 435–441

    Google Scholar 

  • Horton MR, Olman MA, Bao C et al. (2000) Regulation of plasminogen activator inhibitor-1 and urokinase by hyaluronan fragments in mouse macrophages. American journal of physiology Lung cellular and molecular physiology 279: L707–715

    Google Scholar 

  • Isacke CM (1994) The role of the cytoplasmic domain in regulating CD44 function. Journal of cell science 107 ( Pt 9): 2353–2359

    Google Scholar 

  • Ishimoto T, Sugihara H, Watanabe M et al. (2013) Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation. Carcinogenesis:

    Google Scholar 

  • Itano N, Atsumi F, Sawai T et al. (2002) Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Proceedings of the National Academy of Sciences of the United States of America 99: 3609–3614

    Google Scholar 

  • Jacobs PP, Sackstein R (2011) CD44 and HCELL: preventing hematogenous metastasis at step 1. FEBS letters 585: 3148–3158

    Google Scholar 

  • Jiang D, Liang J, Noble PW (2007) Hyaluronan in tissue injury and repair. Annual review of cell and developmental biology 23: 435–461

    Google Scholar 

  • Jiang D, Liang J, Noble PW (2011) Hyaluronan as an immune regulator in human diseases. Physiological reviews 91: 221–264

    Google Scholar 

  • Kern MA, Haugg AM, Koch AF et al. (2006) Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. Cancer research 66: 7059–7066

    Google Scholar 

  • Kobayashi H, Terao T (1997) Hyaluronic acid-specific regulation of cytokines by human uterine fibroblasts. The American journal of physiology 273: C1151–1159

    Google Scholar 

  • Kosaki R, Watanabe K, Yamaguchi Y (1999) Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity. Cancer research 59: 1141–1145

    Google Scholar 

  • Lin L, Liu A, Peng Z et al. (2011) STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer research 71: 7226–7237

    Google Scholar 

  • Liu N, Gao F, Han Z et al. (2001a) Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. Cancer research 61: 5207–5214

    Google Scholar 

  • Liu N, Gao F, Han Z et al. (2001b) Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells. Cancer research 61: 5207–5214

    Google Scholar 

  • Lokeshwar V, Rubinowicz D (1999) Hyaluronic acid and hyaluronidase: molecular markers associated with prostate cancer biology and detection. Prostate cancer and prostatic diseases 2: S21

    Google Scholar 

  • Lu H, Ouyang W, Huang C (2006) Inflammation, a key event in cancer development. Molecular cancer research : MCR 4: 221–233

    Google Scholar 

  • Maeso G, Bravo M, Bascones A (2007) Levels of metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-1 in gingival crevicular fluid of patients with periodontitis, gingivitis, and healthy gingiva. Quintessence Int 38: 247–252

    Google Scholar 

  • Malemud CJ (2013) Suppression of Pro-Inflammatory Cytokines via Targeting of STAT-Responsive Genes. Drug Discovery. InTech,

    Google Scholar 

  • Margolis RU, Margolis RK, Chang LB et al. (1975) Glycosaminoglycans of brain during development. Biochemistry 14: 85–88

    Google Scholar 

  • Marieb EA, Zoltan-Jones A, Li R et al. (2004) Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production. Cancer research 64: 1229–1232

    Google Scholar 

  • May O (2009) COX-2/PGE2 Signaling: A Target for Colorectal Cancer Prevention.

    Google Scholar 

  • McBride WH, Bard JB (1979) Hyaluronidase-sensitive halos around adherent cells. Their role in blocking lymphocyte-mediated cytolysis. The Journal of experimental medicine 149: 507–515

    Google Scholar 

  • Mendillo ML, Santagata S, Koeva M et al. (2012) HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 150: 549–562

    Google Scholar 

  • Meran S, Luo DD, Simpson R et al. (2011) Hyaluronan facilitates transforming growth factor-beta1-dependent proliferation via CD44 and epidermal growth factor receptor interaction. J Biol Chem 286: 17618–17630

    Google Scholar 

  • Misra S, Ghatak S, Zoltan-Jones A et al. (2003) Regulation of multidrug resistance in cancer cells by hyaluronan. J Biol Chem 278: 25285–25288

    Google Scholar 

  • Misra S, Heldin P, Hascall VC et al. (2011) Hyaluronan-CD44 interactions as potential targets for cancer therapy. The FEBS journal 278: 1429–1443

    Google Scholar 

  • Monzón ME, Manzanares D, Schmid N et al. (2008) Hyaluronidase Expression and Activity Is Regulated by Pro-Inflammatory Cytokines in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol 39: 289–295

    Google Scholar 

  • Naor D, Wallach-Dayan SB, Zahalka MA et al. (2008) Involvement of CD44, a molecule with a thousand faces, in cancer dissemination. Seminars in cancer biology 18: 260–267

    Google Scholar 

  • Nikitovic D, Kouvidi K, Karamanos NK et al. (2013) The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression. BioMed research international 2013: 929531

    Google Scholar 

  • Noatynska A, Tavernier N, Gotta M et al. (2013) Coordinating cell polarity and cell cycle progression: what can we learn from flies and worms? Open biology 3: 130083

    Google Scholar 

  • Noble PW (2002) Hyaluronan and its catabolic products in tissue injury and repair. Matrix biology : journal of the International Society for Matrix Biology 21: 25–29

    Google Scholar 

  • Nzeako UC, Guicciardi ME, Yoon JH et al. (2002) COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells. Hepatology 35: 552–559

    Google Scholar 

  • Okabe T, Okamoto I, Tamura K et al. (2007) Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification. Cancer research 67: 2046–2053

    Google Scholar 

  • Okamoto I, Kawano Y, Tsuiki H et al. (1999) CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration. Oncogene 18: 1435–1446

    Google Scholar 

  • Ouhtit A, Abd Elmageed ZY, Abdraboh ME et al. (2007) In vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver. The American journal of pathology 171: 2033–2039

    Google Scholar 

  • Pandey MS, Baggenstoss BA, Washburn J et al. (2013) The hyaluronan receptor for endocytosis (HARE) activates NF-kappaB-mediated gene expression in response to 40-400-kDa, but not smaller or larger, hyaluronans. J Biol Chem 288: 14068–14079

    Google Scholar 

  • Park D, Kim Y, Kim H et al. (2012) Hyaluronic acid promotes angiogenesis by inducing RHAMM-TGF beta receptor interaction via CD44-PKC delta. Mol Cells 33: 563–574

    Google Scholar 

  • Patti ME, Virkamaki A, Landaker EJ et al. (1999) Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes 48: 1562–1571

    Google Scholar 

  • Pelletier J, Bellot G, Gounon P et al. (2012) Glycogen Synthesis is Induced in Hypoxia by the Hypoxia-Inducible Factor and Promotes Cancer Cell Survival. Frontiers in oncology 2: 18

    Google Scholar 

  • Pescador N, Villar D, Cifuentes D et al. (2010) Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. PLoS One 5: e9644

    Google Scholar 

  • Porsch H (2013) Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling., Uppsala University., Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine.

    Google Scholar 

  • Pugh CW, Ratcliffe PJ (2003) Regulation of angiogenesis by hypoxia: role of the HIF system. Nature medicine 9: 677–684

    Google Scholar 

  • Rakoff-Nahoum S (2006) Why cancer and inflammation? The Yale journal of biology and medicine 79: 123–130

    Google Scholar 

  • Roca X, Mate JL, Ariza A et al. (1998) CD44 isoform expression follows two alternative splicing pathways in breast tissue. The American journal of pathology 153: 183–190

    Google Scholar 

  • Salustri A, Camaioni A, Di Giacomo M et al. (1999) Hyaluronan and proteoglycans in ovarian follicles. Human reproduction update 5: 293–301

    Google Scholar 

  • Savani RC, Cao G, Pooler PM et al. (2001) Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis. J Biol Chem 276: 36770–36778

    Google Scholar 

  • Scheibner KA, Lutz MA, Boodoo S et al. (2006) Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. Journal of immunology 177: 1272–1281

    Google Scholar 

  • Schraufstatter IU, Serobyan N, Loring J et al. (2010) Hyaluronan is required for generation of hematopoietic cells during differentiation of human embryonic stem cells. J Stem Cells 5: 9–21

    Google Scholar 

  • Schulz T, Schumacher U, Prante C et al. (2010) Cystic Fibrosis Transmembrane Conductance Regulator Can Export Hyaluronan. Pathobiology 77: 200–209

    Google Scholar 

  • Schulz T, Schumacher U, Prehm P (2007) Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem 282: 20999–21004

    Google Scholar 

  • Shirali AC, Goldstein DR (2008) Activation of the innate immune system by the endogenous ligand hyaluronan. Curr Opin Organ Transplant 13: 20–25

    Google Scholar 

  • Slevin M, Krupinski J, Kumar S et al. (1998) Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation. Laboratory investigation; a journal of technical methods and pathology 78: 987–1003

    Google Scholar 

  • Slevin M, Kumar S, Gaffney J (2002) Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J Biol Chem 277: 41046–41059

    Google Scholar 

  • Slomiany MG, Grass GD, Robertson AD et al. (2009) Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer research 69: 1293–1301

    Google Scholar 

  • Stern R, Asari AA, Sugahara KN (2006) Hyaluronan fragments: an information-rich system. European journal of cell biology 85: 699–715

    Google Scholar 

  • Stern R, Shuster S, Neudecker BA et al. (2002) Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Experimental cell research 276: 24–31

    Google Scholar 

  • Takahashi Y, Li L, Kamiryo M et al. (2005) Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner. J Biol Chem 280: 24195–24204

    Google Scholar 

  • Tammi RH, Passi AG, Rilla K et al. (2011a) Transcriptional and post-translational regulation of hyaluronan synthesis. The FEBS journal 278: 1419–1428

    Google Scholar 

  • Tammi RH, Passi AG, Rilla K et al. (2011b) Transcriptional and post-translational regulation of hyaluronan synthesis. FEBS J 278: 1419–1428

    Google Scholar 

  • Tang B, Vu M, Booker T et al. (2003) TGF-beta switches from tumor suppressor to prometastatic factor in a model of breast cancer progression. The Journal of clinical investigation 112: 1116–1124

    Google Scholar 

  • Taylor KR, Trowbridge JM, Rudisill JA et al. (2004) Hyaluronan fragments stimulate endothelial recognition of injury through TLR4. J Biol Chem 279: 17079–17084

    Google Scholar 

  • Teng BP, Heffler MD, Lai EC et al. (2011) Inhibition of hyaluronan synthase-3 decreases subcutaneous colon cancer growth by increasing apoptosis. Anti-cancer agents in medicinal chemistry 11: 620–628

    Google Scholar 

  • Thorne RF, Legg JW, Isacke CM (2004) The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events. Journal of cell science 117: 373–380

    Google Scholar 

  • Tian X, Azpurua J, Hine C et al. (2013) High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature:

    Google Scholar 

  • Tolg C, Hamilton SR, Nakrieko KA et al. (2006) Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair. The Journal of cell biology 175: 1017–1028

    Google Scholar 

  • Toole BP (2004) Hyaluronan: from extracellular glue to pericellular cue. Nature reviews Cancer 4: 528–539

    Google Scholar 

  • Toole BP (2009) Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities. Clinical cancer research : an official journal of the American Association for Cancer Research 15: 7462–7468

    Google Scholar 

  • Toole BP, Slomiany MG (2008) Hyaluronan, CD44 and Emmprin: partners in cancer cell chemoresistance. Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 11: 110–121

    Google Scholar 

  • Vincent T, Jourdan M, Sy MS et al. (2001a) Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6-mediated pathway involving the phosphorylation of retinoblastoma protein. The Journal of biological chemistry 276: 14728–14736

    Google Scholar 

  • Vincent T, Jourdan M, Sy MS et al. (2001b) Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6-mediated pathway involving the phosphorylation of retinoblastoma protein. Journal of Biological Chemistry 276: 14728–14736

    Google Scholar 

  • Wang SJ, Bourguignon LY (2011) Role of hyaluronan-mediated CD44 signaling in head and neck squamous cell carcinoma progression and chemoresistance. The American journal of pathology 178: 956–963

    Google Scholar 

  • West DC, Hampson IN, Arnold F et al. (1985) Angiogenesis induced by degradation products of hyaluronic acid. Science 228: 1324–1326

    Google Scholar 

  • Wilkinson TS, Potter-Perigo S, Tsoi C et al. (2004) Pro- and anti-inflammatory factors cooperate to control hyaluronan synthesis in lung fibroblasts. Am J Respir Cell Mol Biol 31: 92–99

    Google Scholar 

  • Xu H, Ito T, Tawada A et al. (2002) Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72. J Biol Chem 277: 17308–17314

    Google Scholar 

  • Yevdokimova NY (2006) Elevated level of ambient glucose stimulates the synthesis of high-molecular-weight hyaluronic acid by human mesangial cells. The involvement of transforming growth factor beta1 and its activation by thrombospondin-1. Acta biochimica Polonica 53: 383–393

    Google Scholar 

  • Yoshida S, Pellman D (2008) Plugging the GAP between cell polarity and cell cycle. EMBO reports 9: 39–41

    Google Scholar 

  • Yoshihara S, Kon A, Kudo D et al. (2005) A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS letters 579: 2722–2726

    Google Scholar 

  • Zeilstra J, Joosten SP, Dokter M et al. (2008) Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer research 68: 3655–3661

    Google Scholar 

  • Zhang S, Chang MC, Zylka D et al. (1998) The hyaluronan receptor RHAMM regulates extracellular-regulated kinase. J Biol Chem 273: 11342–11348

    Google Scholar 

  • Zoltan-Jones A, Huang L, Ghatak S et al. (2003) Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. The Journal of biological chemistry 278: 45801–45810

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA

    Ying Xu & David Puett

  2. Department of Computer Science and Engineering, University of Nebraska, Lincoln, NE, USA

    Juan Cui

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Xu, Y., Cui, J., Puett, D. (2014). Hyaluronic Acid: A Key Facilitator of Cancer Evolution. In: Cancer Bioinformatics. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1381-7_6

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1380-0

  • Online ISBN: 978-1-4939-1381-7

  • eBook Packages: Computer ScienceComputer Science (R0)

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