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Macrophages in Obesity and Insulin Resistance

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Macrophages: Biology and Role in the Pathology of Diseases

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Abstract

Obesity-associated adipose tissue inflammation is a key factor contributing to chronic systemic inflammation and insulin resistance. The accumulation of macrophages with a pro-inflammatory phenotype within the adipose tissue has emerged as a crucial factor in the development and maintenance of metabolic inflammation. Thus, unravelling the phenotype and functions of adipose tissue macrophages as well as deciphering the underlying molecular mechanisms is necessary to improve our understanding of the relationship between adipose tissue inflammation, obesity and its metabolic consequences leading to type 2 diabetes.

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Authors and Affiliations

  1. Université de Lille 2, F-59000, Lille, France

    G. Chinetti-Gbaguidi & B. Staels

  2. Inserm U1011, F-59000, Lille, France

    G. Chinetti-Gbaguidi & B. Staels

  3. Inserm UR 1011, Institut Pasteur de Lille, 1, rue du Professeur Calmette, BP 245, F-59019, Lille, France

    G. Chinetti-Gbaguidi & B. Staels

  4. European Genomic Institute for Diabetes (EGID), FR 3508, F-59000, Lille, France

    G. Chinetti-Gbaguidi & B. Staels

Authors
  1. G. Chinetti-Gbaguidi
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  2. B. Staels
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Correspondence to B. Staels .

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Editors and Affiliations

  1. Singapore Immunology Network (SIgN) Biomedical Sciences Institutes, A*STAR, Singapore, Singapore

    Subhra K. Biswas

  2. IRCCS Humanitas Clinical and Research Institute, Humanitas University, Rozzano, Italy

    Alberto Mantovani

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Chinetti-Gbaguidi, G., Staels, B. (2014). Macrophages in Obesity and Insulin Resistance. In: Biswas, S., Mantovani, A. (eds) Macrophages: Biology and Role in the Pathology of Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1311-4_17

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