Application of Microdialysis in Assessing Cutaneous Bioavailability

Chapter

Abstract

This chapter gives a review of microdialysis sampling in the skin with an emphasis on dermal sampling and use in bioequivalence assessment of topical formulations. Microdialysis as a research technique is suitable for a number of different study designs for sampling in the skin or subcutaneous tissues. This versatility includes the option of conducting preclinical studies in animals as well as ex vivo human skin set-ups. The effect of even small alterations in a topical formulation can be detected by simultaneous sampling in several areas in the same person, enabling studies of bioavailability and bioequivalence in study groups of relatively few volunteers or patients. Whenever the dermis is the target tissue, dermal microdialysis can be considered the method of choice for acquisition of human in vivo data.

Keywords

Albumin Propionate Glycol Nicotine Syringe 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Dermatology, Faculty of Health SciencesUniversity of Copenhagen, Roskilde HospitalRoskildeDenmark

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