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Mechanisms of Action of the Bariatric Procedures

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Abstract

Bariatric surgery is the most effective method of sustained long-term weight loss, and it has been extensively proven to ameliorate or resolve most of the associated comorbidities with severe obesity, diabetes included. Traditionally the accepted mechanisms of action of the bariatric procedures were based on the concepts of restriction of calorie intake, malabsorption of nutrients, and a combination of the two. As the close interaction between diet, gut, and brain hormones becomes known, the mechanisms of action of these procedures, as well as their classification, have significantly changed. In fact, it has now become well recognized how the centrally regulated body weight homeostasis is profoundly influenced by hormones secreted in the intestinal tract and adipose tissue. The overall balance of these peripherally secreted hormones and their interaction at the level of the hypothalamus would eventually affect food intake and energy expenditure.

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Authors and Affiliations

  1. Department of General Surgery, The Bariatric and Metabolic Institute, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA

    Emanuele Lo Menzo MD, PhD, FACS, FASMBS, Samuel Szomstein MD, FACS, FASMBS & Raul J. Rosenthal MD, FACS, FASMBS

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  1. Emanuele Lo Menzo MD, PhD, FACS, FASMBS
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  2. Samuel Szomstein MD, FACS, FASMBS
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  3. Raul J. Rosenthal MD, FACS, FASMBS
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Correspondence to Raul J. Rosenthal MD, FACS, FASMBS .

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Editors and Affiliations

  1. Division of Gastrointestinal Surgery, Department of Surgery, University of California, Irvine Medical Center, Orange, California, USA

    Ninh T. Nguyen

  2. Scottsdale Bariatric Center, Scottsdale, Arizona, USA

    Robin P. Blackstone

  3. Section of Bariatric and Minimally Invasive (BMI) Surgery, Stanford School of Medicine, Stanford, California, USA

    John M. Morton

  4. Bariatric Surgery, Hamilton Medical Center, Dalton, Georgia, USA

    Jaime Ponce

  5. Professor of Surgery and Chairman Department of General Surgery Director, The Bariatric and Metabolic Institute Cleveland Clinic, Weston, Florida, USA

    Raul J. Rosenthal

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Lo Menzo, E., Szomstein, S., Rosenthal, R.J. (2015). Mechanisms of Action of the Bariatric Procedures. In: Nguyen, N., Blackstone, R., Morton, J., Ponce, J., Rosenthal, R. (eds) The ASMBS Textbook of Bariatric Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1206-3_5

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