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Management of Castration Resistant Prostate Cancer pp 121–137Cite as

The Emerging Role of Immunotherapy in Castrate-Resistant Prostate Cancer

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Part of the book series: Current Clinical Urology ((CCU))

Abstract

Metastatic, castrate-resistant prostate cancer is a fatal disease with a number of hormonal and non-hormonal treatment options. Among the non-hormonal treatments, immunotherapy has recently emerged as an attractive approach—primarily based on survival data from a randomized controlled study of the personalized vaccine Sipuleucel-T. Several other immunotherapy approaches are in phase III trials, these include the poxvirus-based vaccine ProstVac VF and the immune checkpoint blocking antibody Ipilimumab. Anti-tumor antibodies directed against PSMA are also rapidly moving forward in a number of phase II trials. Although all of these monotherapy approaches have significant promise, preclinical data as well as more recent clinical data in other disease types suggest that an optimal therapeutic regimen will most likely require a combination of several agents, especially the recently approved hormonal therapies Abiraterone Acetate and Enzalutamide.

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Authors and Affiliations

  1. Department of Medical Oncology, Instituto do Cancer do Estado de Sao Paulo – ICESP, Avenida Dr. Arnaldo 251 5o andar, São Paulo, 01246-000, Brazil

    Romualdo Barroso-Sousa MD, PhD

  2. Department of Oncology, Johns Hopkins Kimmel Cancer Center, The Bunting Blaustein Cancer Research Building, 1650 Orleans Street, CRB1/410, Baltimore, MD, 21287, USA

    Charles G. Drake MD, PhD

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  1. Romualdo Barroso-Sousa MD, PhD
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Correspondence to Charles G. Drake MD, PhD .

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  1. Department of Surgery, University of Montreal Hospital Center, Montreal, Québec, Canada

    Fred Saad

  2. Department of Oncology, The Johns Hopkins University, Baltimore, Maryland, USA

    Mario A. Eisenberger

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Barroso-Sousa, R., Drake, C.G. (2014). The Emerging Role of Immunotherapy in Castrate-Resistant Prostate Cancer. In: Saad, F., Eisenberger, M. (eds) Management of Castration Resistant Prostate Cancer. Current Clinical Urology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-1176-9_9

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