Skip to main content

Management of Axilla in Invasive Breast Cancer

  • Chapter
  • First Online:
Breast Disease

Abstract

The majority of invasive breast cancer patients will develop axillary lymph node metastases prior to developing distant metastases. The management of the axilla in the treatment of invasive breast cancer thus remains a critical component of therapy. It influences the AJCC staging of invasive breast cancer. This chapter deals with the evaluation of the axilla. Preoperatively, it includes clinical exam, ultrasound evaluation and fine needle aspiration biopsy (FNA) or core needle biopsy (CNB) of abnormal axillary lymph nodes. Intraoperatively, this includes sentinel lymph node biopsy (SLNB) and completion axillary lymph node dissection (CALND). This review addresses some of the changing philosophy with management of the axilla in invasive breast cancer and the controversies and paradigm shifts that accompany the same. The role of axillary evaluation of breast cancer in certain special situations is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 189.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Townsend: Sabiston Textbook of surgery. 19th ed. Saunders, 2012.

    Google Scholar 

  2. Benson JR. Querci della Rovere G and the Axilla Management Consensus Group. Management of the axilla in women with breast cancer. Lancet Oncol. 2007;8:331–48.

    Article  PubMed  Google Scholar 

  3. Fischer B, Montague F, Redmond C, et al. Ten year results of a randomized trial comparing radical mastectomy and total mastectomy with or without radiation. N Engl J Med. 1985;312:674–81.

    Article  Google Scholar 

  4. Krag D, Anderson S, Julian T, et al. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from NSABP B-32 randomised phase 3 trial. Lancet Oncol. 2010;11:927–31. Cancer Research: December 15, 2012; Volume 72, Issue 24, Supplement 3.

    Article  PubMed Central  PubMed  Google Scholar 

  5. Giuliano A, Hunt K, Ballman K, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis. A randomized clinical trial. J Am Med Assn. 2011;305(6):569–75.

    Article  CAS  Google Scholar 

  6. S3-1. Update of International Breast Cancer Study Group Trial 23-01 to compare axillary dissection versus no axillary dissection in patients with clinically node negative breast cancer and micrometastases in the sentinel node. Galimberti V, Cole BF, Zurrida S, et al. International Breast Cancer Study Group Trial 23-01 Investigators. Abstract presented at San Antonio Breast conference 2011.

    Google Scholar 

  7. De Kanter A, Van Eijck C, Van Geel A, et al. Multicenter study of ultrasonographically guided axillary node biopsy in patients with breast cancer. Br J of Surg. 1999;86:1459–62.

    Article  Google Scholar 

  8. Damera A, Evans A, Cornford E, et al. Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer. Br J of Cancer. 2003;89:1310–3.

    Article  CAS  Google Scholar 

  9. Vidal-Sicart S, Olmos R. Sentinel node mapping for breast cancer: current situation. J Oncol. 2012;2012:361341.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Krishnamurthy S, Meric-Bernstam F, Lucci A, et al. A prospective study comparing touch imprint cytology, frozen section analysis and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer. Cancer Apr. 2009;115:1555–62.

    Article  Google Scholar 

  11. Veys I, Derbecq V, Majjaj S, et al. Eighteen months clinical experience with the Gene search breast lymph node assay. Am J of Surg. 2009;198:203–9.

    Article  Google Scholar 

  12. Krag D, Anderson S, Julian T, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol. 2007;8:881–8.

    Article  CAS  PubMed  Google Scholar 

  13. Erickson V, Pearson M, Ganz P, et al. Arm edema in breast cancer patients. J Natl Cancer Inst. 2001;93:96–111.

    Article  CAS  PubMed  Google Scholar 

  14. Kissin M, della Rovere G Q, Easton D, Westbury G. Risk of lymphoedema following the treatment of breast cancer. Br J Surg. 1986;73:580–4.

    Article  CAS  PubMed  Google Scholar 

  15. Shah C, Wilkinson J, Baschnagel A, et al. Factors associated with the development of breast cancer- related lymphedema after whole breast irradiation. Int J Radiat Oncol Biol Phys. 2012;83(4):1095–100.

    Article  PubMed  Google Scholar 

  16. American Joint Commission on Cancer, 7th ed. Springer, 2009.

    Google Scholar 

  17. Massimino K, Hessman C, Ellis M, et al. Impact of American College of Surgeons Oncology Group Z0011 and National surgical Adjuvant Breast and Bowel Project B-32 trial results on surgeon practice in the Pacific Northwest. Am J of Surg. 2012;203:618–22.

    Article  Google Scholar 

  18. Position statement on management of the axilla in patients with invasive breast cancer. The American Society of Breast Surgeons. 2011.

    Google Scholar 

  19. Straver M, Meijnen P, van Tienhoven G, et al. Role of axillary clearance after a tumor-positive sentinel node in the administration of adjuvant therapy in early breast cancer. J Clin Oncol. 2010;28:731–7.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Boughey JC, Suman VJ, Mittendorf EA, et al. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: The ACOSOG Z1071 (alliance) clinical trial. JAMA. 2013;310(14):1455–1461. doi: 10.1001/jama.2013.278932.

  21. Sabel MS. Sentinel lymph node biopsy before or after neoadjuvant chemotherapy: pros and cons. Surg Oncol Clin N Am. 2010;19(3):519–38.

    Article  PubMed  Google Scholar 

  22. Mamounas E, Brown A, Anderson S, et al. Sentinel node biopsy after neoadjuvant chemotherapy in breast cancer: results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol. 2005;23:2694–702.

    Article  PubMed  Google Scholar 

  23. Wilke C, White L, et al. An update of sentinel lymph node mapping in patients with ductal carcinoma in situ. Am J Surg. 2005;190:563–6.

    Article  Google Scholar 

  24. Hulvat M, Hansen N, Jeruss J. Multidisciplinary care for patients with breast cancer. Surg Clin N Am. 2009;89:133–76.

    Article  PubMed  Google Scholar 

  25. Cox C, Furman B, Kiluk J, et al. Use of reoperative sentinel lymph node biopsy in breast cancer patients. J Am Coll Surg. 2008;207:57–61.

    Article  PubMed  Google Scholar 

  26. Biganzoli L, Wildiers H, Oakman C, et al. Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). Lancet Oncol. 2012;13:e148–60.

    Article  PubMed  Google Scholar 

  27. Galimberti V, Cole B, Viale V, et al. Axillary dissection Vs no axillary dissection in patients with sentinel lymph node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lancet Oncol. 2013;14:297–305.

    Article  PubMed Central  PubMed  Google Scholar 

  28. Karam A, Stempel M, Cody H, Port E. Reoperative sentinel lymph node biopsy after previous mastectomy. J Am Coll Surg. 2008;207:543–8.

    Article  PubMed  Google Scholar 

  29. Ansari B, Boughey J. Sentinel lymph node surgery in uncommon clinical circumstances. Surg Oncol Clin N Am. 2010;19:539–53.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paulomi Shroff MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Shroff, P., Israel, P. (2015). Management of Axilla in Invasive Breast Cancer. In: Riker, A. (eds) Breast Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1145-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-1145-5_12

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1144-8

  • Online ISBN: 978-1-4939-1145-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics