Abstract
The majority of invasive breast cancer patients will develop axillary lymph node metastases prior to developing distant metastases. The management of the axilla in the treatment of invasive breast cancer thus remains a critical component of therapy. It influences the AJCC staging of invasive breast cancer. This chapter deals with the evaluation of the axilla. Preoperatively, it includes clinical exam, ultrasound evaluation and fine needle aspiration biopsy (FNA) or core needle biopsy (CNB) of abnormal axillary lymph nodes. Intraoperatively, this includes sentinel lymph node biopsy (SLNB) and completion axillary lymph node dissection (CALND). This review addresses some of the changing philosophy with management of the axilla in invasive breast cancer and the controversies and paradigm shifts that accompany the same. The role of axillary evaluation of breast cancer in certain special situations is discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Townsend: Sabiston Textbook of surgery. 19th ed. Saunders, 2012.
Benson JR. Querci della Rovere G and the Axilla Management Consensus Group. Management of the axilla in women with breast cancer. Lancet Oncol. 2007;8:331–48.
Fischer B, Montague F, Redmond C, et al. Ten year results of a randomized trial comparing radical mastectomy and total mastectomy with or without radiation. N Engl J Med. 1985;312:674–81.
Krag D, Anderson S, Julian T, et al. Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from NSABP B-32 randomised phase 3 trial. Lancet Oncol. 2010;11:927–31. Cancer Research: December 15, 2012; Volume 72, Issue 24, Supplement 3.
Giuliano A, Hunt K, Ballman K, et al. Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis. A randomized clinical trial. J Am Med Assn. 2011;305(6):569–75.
S3-1. Update of International Breast Cancer Study Group Trial 23-01 to compare axillary dissection versus no axillary dissection in patients with clinically node negative breast cancer and micrometastases in the sentinel node. Galimberti V, Cole BF, Zurrida S, et al. International Breast Cancer Study Group Trial 23-01 Investigators. Abstract presented at San Antonio Breast conference 2011.
De Kanter A, Van Eijck C, Van Geel A, et al. Multicenter study of ultrasonographically guided axillary node biopsy in patients with breast cancer. Br J of Surg. 1999;86:1459–62.
Damera A, Evans A, Cornford E, et al. Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer. Br J of Cancer. 2003;89:1310–3.
Vidal-Sicart S, Olmos R. Sentinel node mapping for breast cancer: current situation. J Oncol. 2012;2012:361341.
Krishnamurthy S, Meric-Bernstam F, Lucci A, et al. A prospective study comparing touch imprint cytology, frozen section analysis and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer. Cancer Apr. 2009;115:1555–62.
Veys I, Derbecq V, Majjaj S, et al. Eighteen months clinical experience with the Gene search breast lymph node assay. Am J of Surg. 2009;198:203–9.
Krag D, Anderson S, Julian T, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol. 2007;8:881–8.
Erickson V, Pearson M, Ganz P, et al. Arm edema in breast cancer patients. J Natl Cancer Inst. 2001;93:96–111.
Kissin M, della Rovere G Q, Easton D, Westbury G. Risk of lymphoedema following the treatment of breast cancer. Br J Surg. 1986;73:580–4.
Shah C, Wilkinson J, Baschnagel A, et al. Factors associated with the development of breast cancer- related lymphedema after whole breast irradiation. Int J Radiat Oncol Biol Phys. 2012;83(4):1095–100.
American Joint Commission on Cancer, 7th ed. Springer, 2009.
Massimino K, Hessman C, Ellis M, et al. Impact of American College of Surgeons Oncology Group Z0011 and National surgical Adjuvant Breast and Bowel Project B-32 trial results on surgeon practice in the Pacific Northwest. Am J of Surg. 2012;203:618–22.
Position statement on management of the axilla in patients with invasive breast cancer. The American Society of Breast Surgeons. 2011.
Straver M, Meijnen P, van Tienhoven G, et al. Role of axillary clearance after a tumor-positive sentinel node in the administration of adjuvant therapy in early breast cancer. J Clin Oncol. 2010;28:731–7.
Boughey JC, Suman VJ, Mittendorf EA, et al. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: The ACOSOG Z1071 (alliance) clinical trial. JAMA. 2013;310(14):1455–1461. doi: 10.1001/jama.2013.278932.
Sabel MS. Sentinel lymph node biopsy before or after neoadjuvant chemotherapy: pros and cons. Surg Oncol Clin N Am. 2010;19(3):519–38.
Mamounas E, Brown A, Anderson S, et al. Sentinel node biopsy after neoadjuvant chemotherapy in breast cancer: results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27. J Clin Oncol. 2005;23:2694–702.
Wilke C, White L, et al. An update of sentinel lymph node mapping in patients with ductal carcinoma in situ. Am J Surg. 2005;190:563–6.
Hulvat M, Hansen N, Jeruss J. Multidisciplinary care for patients with breast cancer. Surg Clin N Am. 2009;89:133–76.
Cox C, Furman B, Kiluk J, et al. Use of reoperative sentinel lymph node biopsy in breast cancer patients. J Am Coll Surg. 2008;207:57–61.
Biganzoli L, Wildiers H, Oakman C, et al. Management of elderly patients with breast cancer: updated recommendations of the International Society of Geriatric Oncology (SIOG) and European Society of Breast Cancer Specialists (EUSOMA). Lancet Oncol. 2012;13:e148–60.
Galimberti V, Cole B, Viale V, et al. Axillary dissection Vs no axillary dissection in patients with sentinel lymph node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lancet Oncol. 2013;14:297–305.
Karam A, Stempel M, Cody H, Port E. Reoperative sentinel lymph node biopsy after previous mastectomy. J Am Coll Surg. 2008;207:543–8.
Ansari B, Boughey J. Sentinel lymph node surgery in uncommon clinical circumstances. Surg Oncol Clin N Am. 2010;19:539–53.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Science+Business Media New York
About this chapter
Cite this chapter
Shroff, P., Israel, P. (2015). Management of Axilla in Invasive Breast Cancer. In: Riker, A. (eds) Breast Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1145-5_12
Download citation
DOI: https://doi.org/10.1007/978-1-4939-1145-5_12
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-1144-8
Online ISBN: 978-1-4939-1145-5
eBook Packages: MedicineMedicine (R0)