Approaches for Clinical Supply Modelling and Simulation

  • Nitin R. PatelEmail author
  • Suresh Ankolekar
  • Pralay Senchaudhuri
Part of the Statistics for Biology and Health book series (SBH)


Clinical supply is impacted by decisions and events at every stage of a clinical trial. Protocol design, logistics planning, and operational dynamics pose challenges to the management of clinical supply in terms of complexity and uncertainty. In this chapter, we propose a simulation modelling approach to address these issues and support decision-makers in effectively managing clinical supply. The approach is comprehensively described in terms of underlying structure and process, and is illustrated with adaptive trials involving dropping of arms and a Bayesian responsive-adaptive design for dose finding.


Adaptive clinical trials Clinical supply Simulation modelling Bayesian response-adaptive design 


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Nitin R. Patel
    • 1
    Email author
  • Suresh Ankolekar
    • 2
  • Pralay Senchaudhuri
    • 1
  1. 1.Cytel Inc.CambridgeUSA
  2. 2.Maastricht School of ManagementMaastrichtThe Netherlands

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