Integrative Oncology

  • Gabriel Lopez
  • Richard Lee
  • M. Kay Garcia
  • Alejandro Chaoul
  • Lorenzo Cohen
Chapter
Part of the MD Anderson Cancer Care Series book series (MDCCS)

Abstract

Integrative oncology is an expanding discipline holding tremendous promise for additional treatment and symptom control options. An integrative approach provides patients with a comprehensive system of care to help meet their needs, from diagnosis through survivorship. Most patients with cancer are either using complementary medicines or want to know more about them, so it is incumbent on the conventional medical system to provide appropriate education and evidenced-based clinical services. The clinical model for integrative care requires a patient-centered approach with attention to patient concerns and enhanced communication skills. In addition, it is essential that conventional and nonconventional practitioners work together to develop a comprehensive, integrative care plan. In this way, patients with cancer will receive the best medical care making use of all appropriate treatment modalities in a safe manner to achieve optimal clinical outcomes.

Keywords

Placebo Fatigue Obesity Depression Estrogen 

Suggested Readings

  1. Adler NE, Page AEK. Cancer Care for the Whole Patient: Meeting Psychosocial Health Needs. Washington, DC: National Academy Press; 2008.Google Scholar
  2. Alimi D, Rubino C, Pichard L, et al. Analgesic effect of auricular acupuncture for cancer pain: a randomized, blinded, controlled trial. J Clin Oncol 2003;21:4120–4126.PubMedCrossRefGoogle Scholar
  3. Andersen BL, Thornton LM, Shapiro CL, et al. Biobehavioral, immune, and health benefits following recurrence for psychological intervention participants. Clin Cancer Res 2010;16:3270–3278.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Antoni MH, Lutgendorf SK, Cole SW, et al. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat Rev Cancer 2006;6:240–248.PubMedCrossRefPubMedCentralGoogle Scholar
  5. Bairati I, Meyer F, Gélinas M, et al. A randomized trial of antioxidant vitamins to prevent second primary cancers in head and neck cancer patients. J Natl Cancer Inst 2005a;97:481–488.PubMedCrossRefGoogle Scholar
  6. Bairati I, Meyer F, Gélinas M, et al. Randomized trial of antioxidant vitamins to prevent acute adverse effects of radiation therapy in head and neck cancer patients. J Clin Oncol 2005b;23:5805–5813.PubMedCrossRefGoogle Scholar
  7. Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report 2008;12:1–23.PubMedGoogle Scholar
  8. Block KI, Koch AC, Mead MN, et al. Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Cancer Treat Rev 2007;33:407–418.PubMedCrossRefGoogle Scholar
  9. Chlebowski RT, Blackburn GL, Thomson CA, et al. Dietary fat reduction and breast cancer outcome: interim efficacy results from the Women’s Intervention Nutrition Study. J Natl Cancer Inst 2006;98:1767–1776.PubMedCrossRefGoogle Scholar
  10. Cohen L, Warneke C, Fouladi RT, Rodriguez MA, Chaoul-Reich A. Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma. Cancer 2004;100:2253–2260.PubMedCrossRefGoogle Scholar
  11. Consortium of Academic Health Centers for Integrative Medicine. About CAHCIM. http://www.imconsortium.org/about/home.html. Updated November 2009. Accessed September 26, 2013.
  12. Crew KD, Capodice JL, Greenlee H, et al. Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer. J Clin Oncol 2010;28:1154–1160.PubMedCrossRefGoogle Scholar
  13. Deng GE, Frenkel M, Cohen L, et al. Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. J Soc Integr Oncol 2009;7:85–120.PubMedGoogle Scholar
  14. Engel GL. The need for a new medical model: a challenge for biomedicine. Science 1977;196:129–136.PubMedCrossRefGoogle Scholar
  15. Garcia MK, McQuade J, Haddad R, et al. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol 2013;31:952–960.PubMedCrossRefPubMedCentralGoogle Scholar
  16. Glaser R, Kiecolt-Glaser JK. Stress-induced immune dysfunction: implications for health. Nat Rev Immunol 2005;5:243–251.PubMedCrossRefGoogle Scholar
  17. Helms JM. Acupuncture Energetics: A Clinical Approach for Physicians. Berkeley, CA: Medical Acupuncture Publishers; 1995.Google Scholar
  18. Kushi LH, Doyle C, McCullough M, et al. American Cancer Society Guidelines on nutrition and physical activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin 2012;62:30–67.PubMedCrossRefGoogle Scholar
  19. Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 2008;100:773–783.PubMedCrossRefGoogle Scholar
  20. Litton JK, Gonzalez-Angulo AM, Warneke CL, et al. Relationship between obesity and pathologic response to neoadjuvant chemotherapy among women with operable breast cancer. J Clin Oncol 2008;26:4072–4077.PubMedCrossRefGoogle Scholar
  21. Lutgendorf SK, Sood AK, Antoni MH. Host factors and cancer progression: biobehavioral signaling pathways and interventions. J Clin Oncol 2010;28:4094–4099.PubMedCrossRefPubMedCentralGoogle Scholar
  22. Meng Z, Garcia MK, Hu C, et al. Randomized controlled trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma. Cancer 2012;118:3337–3344.PubMedCrossRefPubMedCentralGoogle Scholar
  23. Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol 2006;24:3535–3541.PubMedCrossRefGoogle Scholar
  24. Meyerhardt JA, Niedzwiecki D, Hollis D, et al. Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer. JAMA 2007;298:754–764.PubMedCrossRefGoogle Scholar
  25. Navo MA, Phan J, Vaughan C, et al. An assessment of the utilization of complementary and alternative medication in women with gynecologic or breast malignancies. J Clin Oncol 2004;22:671–677.PubMedCrossRefGoogle Scholar
  26. Newell SA, Sanson-Fisher W, Savolainen NJ. Systematic review of psychological therapies for cancer patients: overview and recommendations for future research. J Natl Cancer Inst 2002;94:558–584.PubMedCrossRefGoogle Scholar
  27. Palmer ME, Haller C, McKinney PE, et al. Adverse events associated with dietary supplements: an observational study. Lancet 2003;361:101–106.PubMedCrossRefGoogle Scholar
  28. Pierce JP, Stefanick ML, Flatt SW, et al. Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity. J Clin Oncol 2007;25:2345–2351.PubMedCrossRefPubMedCentralGoogle Scholar
  29. Quinten C, Coens C, Mauer M, et al. Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials. Lancet Oncol 2009;10:865–871.PubMedCrossRefGoogle Scholar
  30. Richardson MA, Sanders T, Palmer JL, Greisinger A, Singletary SE. Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology. J Clin Oncol 2000;18:2505–2514.PubMedGoogle Scholar
  31. Russell NC, Sumler SS, Beinhorn CM, Frenkel MA. Role of massage therapy in cancer care. J Altern Complement Med 2008;14:209–214.PubMedCrossRefGoogle Scholar
  32. Smith P, Bullock JM, Booker BM, Haas CE, Berenson CS, Jusko WJ. The influence of St. John’s wort on the pharmacokinetics and protein binding of imatinib mesylate. Pharmacotherapy 2004;24:1508–1514.PubMedCrossRefGoogle Scholar
  33. Syrjala KL, Chapko ME. Evidence for a biopsychosocial model of cancer treatment-related pain. Pain 1995;61:69–79.PubMedCrossRefGoogle Scholar
  34. Ulbricht C, Chao W, Costa D, Rusie-Seamon E, Weissner W, Woods J. Clinical evidence of herb-drug interactions: a systematic review by the natural standard research collaboration. Curr Drug Metab 2008;9:1063–1120.PubMedCrossRefGoogle Scholar
  35. Verhoef MJ, White MA, Doll R. Cancer patients’ expectations of the role of family physicians in communication about complementary therapies. Cancer Prev Control 1999;3:181–187.PubMedGoogle Scholar
  36. Walker EM, Rodriguez AI, Kohn B, et al. Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial. J Clin Oncol 2010;28:634–640.PubMedCrossRefGoogle Scholar

Copyright information

© The University of Texas M. D. Anderson Cancer Center 2015

Authors and Affiliations

  • Gabriel Lopez
    • 1
  • Richard Lee
    • 1
  • M. Kay Garcia
    • 1
  • Alejandro Chaoul
    • 1
  • Lorenzo Cohen
    • 1
  1. 1.Integrative Medicine Program, Department of General OncologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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