• Carmen P. Escalante
  • Ellen F. Manzullo
Part of the MD Anderson Cancer Care Series book series (MDCCS)


Fatigue is a common symptom experienced by cancer survivors. It is important for the clinician to question the patient about the presence of this symptom because patients are often hesitant to mention it. In addition, cancer-related fatigue (CRF) commonly clusters with other symptoms, such as sleep disturbance, pain, depression, and anxiety. Patients with moderate to severe CRF should undergo a comprehensive evaluation that includes a history, physical examination, laboratory evaluation, and an assessment of their fatigue and possible associated symptoms. Nonpharmacologic interventions for the treatment of CRF include psychosocial interventions, activity enhancement, dietary management, and sleep management; pharmacologic interventions include agents such as stimulants. Further research is needed to elucidate the actual pathophysiology of CRF and better tailor treatment strategies.


Obstructive Sleep Apnea Cancer Survivor National Comprehensive Cancer Network Psychosocial Intervention Activity Enhancement 
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Copyright information

© The University of Texas M. D. Anderson Cancer Center 2015

Authors and Affiliations

  • Carmen P. Escalante
    • 1
  • Ellen F. Manzullo
    • 1
  1. 1.Department of General Internal MedicineThe University of Texas MD Anderson Cancer CenterHoustonUSA

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