Skip to main content
SpringerLink
Log in

Hematologic Cancer Survivorship Management: Transplantation

  • Chapter
  • First Online:
Advances in Cancer Survivorship Management

Part of the book series: MD Anderson Cancer Care Series ((MDCCS))

  • 1272 Accesses

Abstract

This chapter will review the late effects of treatment impacting hematopoietic stem cell transplantation (HSCT) survivors. In general, HSCT patients receive high doses of chemotherapy with or without radiation therapy to eradicate their malignancy, together with an infusion of their own (autologous) or another person’s (allogeneic) stem cells to restore hematopoiesis (the blood and immune system). Allogeneic cells may be from bone marrow, peripheral blood, or umbilical cord blood obtained from a related or unrelated donor. Patients experience the toxic effects of the cytotoxic treatment and are at high risk for infections owing to posttransplant immune deficiency. Late effects for HSCT survivors are commonly compounded by the toxic effects of their previous cancer treatment. This chapter will cover physiologic and psychological aspects of survivorship for HSCT patients, as well as graft-versus-host disease, a common and frequently chronic condition that occurs after allogeneic HSCT.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Suggested Readings

  • Al-Hazzouri A, Cao Q, Burns LJ, et al. Similar risks for chronic kidney disease in long-term survivors of myeloablative and reduced-intensity allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant 2008;14:658–663.

    Article  PubMed  Google Scholar 

  • Bjorklund A, Aschan J, Labopin M, et al. Risk factors for fatal infectious complications developing late after allogeneic stem cell transplantation. Bone Marrow Transplant 2007;40:1055–1062.

    Article  PubMed  CAS  Google Scholar 

  • den Haan JM, Sherman NE, Blokland E, et al. Identification of a graft versus host disease-associated human minor histocompatibility antigen. Science 1995;268:1476–1480.

    Article  Google Scholar 

  • Dobr T, Passweg J, Weber C, et al. Oral health risks associated with HLA-types of patients undergoing hematopoietic stem cell transplantation. Eur J Haematol 2007;78:495–499.

    Article  PubMed  Google Scholar 

  • Dudek AZ, Mahaseth H. Hematopoietic stem cell transplant-related airflow obstruction. Curr Opin Oncol 2006;18:115–119.

    Article  PubMed  Google Scholar 

  • Fadol A, Mendoza T, Gning I, et al. Psychometric testing of the MDASI-HF: a symptom assessment instrument for patients with cancer and concurrent heart failure. J Card Fail 2008;14:497–507.

    Article  PubMed  Google Scholar 

  • Filipovich AH, Weisdorf D, Pavletic S, et al. National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 2005;11:945–956.

    Article  PubMed  Google Scholar 

  • Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcome. Blood 2004;104:1923–1930.

    Article  PubMed  CAS  Google Scholar 

  • Fraser CJ, Bhatia S, Ness K, et al. Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor Study. Blood 2006;108:2867–2873.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Gale RP, Bortin MM, van Bekkum DW, et al. Risk factors for acute graft-versus-host disease. Br J Haematol 1987;67:397–406.

    Article  PubMed  CAS  Google Scholar 

  • Goulmy E, Schipper R, Pool J, et al. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N Engl J Med 1996;334:281–285.

    Article  PubMed  CAS  Google Scholar 

  • Grundy SM, Cleeman JI, Daniels SR, et al. Diagnosis and management of the metabolic syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Executive summary. Cardiol Rev 2005;13:322–327.

    PubMed  Google Scholar 

  • Hahn T, McCarthy PL, Jr., Zhang MJ, et al. Risk factors for acute graft-versus-host disease after human leukocyte antigen-identical sibling transplants for adults with leukemia. J Clin Oncol 2008;26:5728–5734.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hingorani S. Chronic kidney disease after liver, cardiac, lung, heart-lung, and hematopoietic stem cell transplant. Pediatr Nephrol 2008;23:879–888.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jacobs SR, Small BJ, Booth-Jones M, et al. Changes in cognitive functioning in the year after hematopoietic stem cell transplantation. Cancer 2007;110:1560–1567.

    Article  PubMed  Google Scholar 

  • Kersting S, Koomans HA, Hene RJ, et al. Acute renal failure after allogeneic myeloablative stem cell transplantation: retrospective analysis of incidence, risk factors and survival. Bone Marrow Transplant 2007;39:359–365.

    Article  PubMed  CAS  Google Scholar 

  • Lee SJ, Flowers ME. Recognizing and managing chronic graft-versus-host disease. Hematology Am Soc Hematol Educ Program 2008:134–141.

    Google Scholar 

  • Lee SJ, Klein JP, Barrett AJ, et al. Severity of chronic graft-versus-host disease: association with treatment-related mortality and relapse. Blood 2002;100:406–414.

    Article  PubMed  CAS  Google Scholar 

  • Lee SJ, Loberiza FR, Antin JH, et al. Routine screening for psychosocial distress following hematopoietic stem cell transplantation. Bone Marrow Transplant 2005;35:77–83.

    Article  PubMed  CAS  Google Scholar 

  • Leite SC, de Castro RS, Alves M, et al. Risk factors and characteristics of ocular complications, and efficacy of autologous serum tears after haematopoietic progenitor cell transplantation. Bone Marrow Transplant 2006;38:223–227.

    Article  PubMed  CAS  Google Scholar 

  • Loberiza FR, Jr., Rizzo JD, Bredeson CN, et al. Association of depressive syndrome and early deaths among patients after stem-cell transplantation for malignant diseases. J Clin Oncol 2002;20:2118–2126.

    Article  PubMed  Google Scholar 

  • Loren AW, Chow E, Jacobsohn DA, et al. Pregnancy after hematopoietic cell transplantation: a report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR). Biol Blood Marrow Transplant 2011;17:157–166.

    Article  PubMed  PubMed Central  Google Scholar 

  • Majhail NS. Old and new cancers after hematopoietic-cell transplantation. Hematology Am Soc Hematol Educ Program 2008;2008:142–149.

    Article  Google Scholar 

  • Majhail NS, Brazauskas R, Rizzo JD, et al. Secondary solid cancers after allogeneic hematopoietic cell transplantation using busulfan-cyclophosphamide conditioning. Blood 2011;117:316–322.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Mohty M, Apperley JF. Long-term physiological side effects after allogeneic bone marrow transplantation. Hematology Am Soc Hematol Educ Program 2011;2010:229–236.

    Article  Google Scholar 

  • Molldrem JJ, Komanduri K, Wieder E. Overexpressed differentiation antigens as targets of graft-versus-leukemia reactions. Curr Opin Hematol 2002;9:503–508.

    Article  PubMed  Google Scholar 

  • Mosher CE, Redd WH, Rini CM, et al. Physical, psychological, and social sequelae following hematopoietic stem cell transplantation: a review of the literature. Psychooncology 2009;18:113–127.

    Article  PubMed  PubMed Central  Google Scholar 

  • Pandya CM, Soubani AO. Bronchiolitis obliterans following hematopoietic stem cell transplantation: a clinical update. Clin Transplant 2010;24:291–306.

    Article  PubMed  Google Scholar 

  • Patriarca F, Poletti V, Costabel U, et al. Clinical presentation, outcome and risk factors of late-onset non-infectious pulmonary complications after allogeneic stem cell transplantation. Curr Stem Cell Res Ther 2009;4:161–167.

    Article  PubMed  CAS  Google Scholar 

  • Poppelreuter M, Weis J, Mumm A, et al. Rehabilitation of therapy-related cognitive deficits in patients after hematopoietic stem cell transplantation. Bone Marrow Transplant 2008;41:79–90.

    Article  PubMed  CAS  Google Scholar 

  • Prasad VK, Kernan NA, Heller G, et al. DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. Blood 1999;93:399–409.

    PubMed  CAS  Google Scholar 

  • Przepiorka D, Anderlini P, Saliba R, et al. Chronic graft-versus-host disease after allogeneic blood stem cell transplantation. Blood 2001;98:1695–1700.

    Article  PubMed  CAS  Google Scholar 

  • Remberger M, Kumlien G, Aschan J, et al. Risk factors for moderate-to-severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2002;8:674–682.

    Article  PubMed  Google Scholar 

  • Rizzo JD, Curtis RE, Socie G, et al. Solid cancers after allogeneic hematopoietic cell transplantation. Blood 2009;113:1175–1183.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Robin M, Porcher R, De Castro Araujo R, et al. Risk factors for late infections after allogeneic hematopoietic stem cell transplantation from a matched related donor. Biol Blood Marrow Transplant 2007;13:1304–1312.

    Google Scholar 

  • Roziakova L, Mladosievicova B. Endocrine late effects after hematopoietic stem cell transplantation. Oncol Res 2010;18:607–615.

    Article  PubMed  Google Scholar 

  • Schulmeister L, Quiett K, Mayer K. Quality of life, quality of care, and patient satisfaction: perceptions of patients undergoing outpatient autologous stem cell transplantation. Oncol Nurs Forum 2005;32:57–67.

    Article  PubMed  Google Scholar 

  • Schwartz JL, Kopecky KJ, Mathes RW, et al. Basal cell skin cancer after total-body irradiation and hematopoietic cell transplantation. Radiat Res 2009;171:155–163.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Socie G, Salooja N, Cohen A, et al. Nonmalignant late effects after allogeneic stem cell transplantation. Blood 2003;101:3373–3385.

    Article  PubMed  CAS  Google Scholar 

  • Socie G, Tichelli A. Long-term care after stem-cell transplantation. Hematol J 2004;5 Suppl 3:S39–S43.

    Article  PubMed  Google Scholar 

  • Syrjala KL, Kurland BF, Abrams JR, et al. Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy, with case-matched controls at 5 years. Blood 2008;111:989–996.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Syrjala KL, Langer SL, Abrams JR, et al. Recovery and long-term function after hematopoietic cell transplantation for leukemia or lymphoma. JAMA 2004;291:2335–2343.

    Article  PubMed  CAS  Google Scholar 

  • Syrjala KL, Langer SL, Abrams JR, et al. Late effects of hematopoietic cell transplantation among 10-year adult survivors compared with case-matched controls. J Clin Oncol 2005;23:6596–6606.

    Article  PubMed  Google Scholar 

  • Tichelli A, Bucher C, Rovo A, et al. Premature cardiovascular disease after allogeneic hematopoietic stem-cell transplantation. Blood 2007;110:3463–3471.

    Article  PubMed  CAS  Google Scholar 

  • Tichelli A, Rovo A, Gratwohl A. Late pulmonary, cardiovascular, and renal complications after hematopoietic stem cell transplantation and recommended screening practices. Hematology Am Soc Hematol Educ Program 2008;2008:125–133.

    Article  Google Scholar 

  • Tichelli A, Rovo A, Passweg J, et al. Late complications after hematopoietic stem cell transplantation. Expert Rev Hematol 2009;2:583–601.

    Article  PubMed  Google Scholar 

  • Tomblyn M, Chiller T, Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic cell transplant recipients: a global perspective. Preface. Bone Marrow Transplant 2009;44:453–455.

    Article  PubMed  CAS  Google Scholar 

  • Witherspoon RP, Deeg HJ, Lum LG, et al. Immunologic recovery in human marrow graft recipients given cyclosporine or methotrexate for the prevention of graft-versus-host disease. Transplantation 1984;37:456–461.

    Article  PubMed  CAS  Google Scholar 

  • Worel N, Biener D, Kalhs P, et al. Long-term outcome and quality of life of patients who are alive and in complete remission more than two years after allogeneic and syngeneic stem cell transplantation. Bone Marrow Transplant 2002;30:619–626.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Karen Stolar MS, FNP-BC, AOCN (Advanced Practice Nurse), Amin Alousi MD (Associate Professor), Joyce Neumann MSN, RN, AOCN (Advanced Practice Nurse and Program Director) & Richard Champlin MD (Professor of Medicine and Chair of Clinical Care)

Authors
  1. Karen Stolar MS, FNP-BC, AOCN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amin Alousi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Joyce Neumann MSN, RN, AOCN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Richard Champlin MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Lewis E. Foxhall

  2. Department of Lymphoma/Myeloma, Division of Medical Affairs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Maria Alma Rodriguez

Rights and permissions

Reprints and permissions

Copyright information

© 2015 The University of Texas M. D. Anderson Cancer Center

About this chapter

Cite this chapter

Stolar, K., Alousi, A., Neumann, J., Champlin, R. (2015). Hematologic Cancer Survivorship Management: Transplantation. In: Foxhall, L., Rodriguez, M. (eds) Advances in Cancer Survivorship Management. MD Anderson Cancer Care Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-0986-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-0986-5_10

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-0985-8

  • Online ISBN: 978-1-4939-0986-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation