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Kidney Development in Renal Pathology pp 59–66Cite as

Perinatal Asphyxia and Kidney Development

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Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

Renal injury is a severe and extremely common complication that occurs early in neonates with asphyxia, occurring in up to 56 % of these infants.

The newborn presents in basal conditions compared to the adult, a state of relative renal insufficiency, including reduced renal blood flow and high renal vascular resistance (the neonate’s kidney is halfway towards acute renal insufficiency). Many drugs are usually administered to sick newborns, especially preterm infants, and they may further worsen the renal function, thus leading to an amplification of the damage.

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References

  1. Chantler C. Renal failure in childhood. In: Black D, Jones NF, editors. Renal disease. Oxford: Blackwell; 1987. p. 825–69.

    Google Scholar 

  2. Fanos V, Cataldi L. Antibacterial – induced nephrotoxicity in the newborn. Drug Saf. 1999;20:245–69.

    Article  CAS  PubMed  Google Scholar 

  3. Durkan AM, Alexander RT. Acute kidney injury post neonatal asphyxia. J Pediatr. 2011;158(2 Suppl):e29–33.

    Article  PubMed  Google Scholar 

  4. Gouyon JB, Vallotton M, Guignard JP. The newborn rabbit: a model for studying hypoxemia-induced renal changes. Biol Neonate. 1987;52:115–20.

    Article  CAS  PubMed  Google Scholar 

  5. Fanos V, Khoory BJ, Cataldi L. Postischaemic acute renal failure in newborns: physiopathological aspects and early diagnosis. In: Cataldi L, Fanos V, Simeoni U, editors. Neonatal nephrology in progress. Italy: Agorà Ed. Lecce; 1996. p. 237–49.

    Google Scholar 

  6. Atzori L, Xanthos T, Barberini L, Antonucci R, Murgia F, Lussu M, Aroni F, Varsami Papalois A, Lai A, D’aloja E, Iacovidou N, Fanos V. A metabolomic approach in an experimental model of hypoxia-reoxygenation in newborn piglets: urine predicts outcome. J Mat Fet Neonat Med. 2010;23:134–137, ISSN:1476–4954.

    Google Scholar 

  7. Zhao J, Dong WB, Li PY, Deng CL. Mechanism of intracellular signal transduction during injury of renal tubular cells induced by postasphyxial serum in neonates with asphyxia. Neonatology. 2009;96(1):33–42.

    Article  CAS  PubMed  Google Scholar 

  8. Summers WK, Jamison RL. The no reflow phenomenon in renal ischemia. Lab Invest. 1971;25(6):635–43.

    CAS  PubMed  Google Scholar 

  9. Johannes T, Mik EG, Nohé B, Raat NJ, Unertl KE, Ince C. Influence of fluid resuscitation on renal microvascular PO2 in a normotensive rat model of endotoxemia. Crit Care. 2006;10(3):R88.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Fanos V, Atzori L, Dessì A, D’Aloja E, Finco G, Faa G. The kidney in post-asphyctic syndrome: state of the art. In: Fanos V, Chevalier RL, Faa G, Cataldi L, editors. Developmental Nephrology: from embryology to metabolomics. Quartu S. Elena: Hygeia Press; 2011.

    Google Scholar 

  11. Janssen WM, Beekhuis H, de Bruin R, de Jong PE, de Zeeuw D. Non invasive measurement of intrarenal blood flow distribution: kinetic model of renal 123I-hippuran handling. Am J Physiol. 1995;269:F571–80.

    CAS  PubMed  Google Scholar 

  12. Pallone TL, Robertson CR, Jamison RL. Renal medullary microcirculation. Physiol Rev. 1990;70(3):885–920.

    CAS  PubMed  Google Scholar 

  13. Zhang Y, Dong WB, Li QP, Deng CL, Xiong T, Lei XP, Guo L. Role of Omi/HtrA2 in renal tubular cells apoptosis induced by post asphyxial serum of neonate. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2009;21(6):346–8.

    CAS  PubMed  Google Scholar 

  14. Andreoli SP. Acute kidney injury in children. Pediatr Nephrol. 2009;24(2):253–63.

    Article  PubMed Central  PubMed  Google Scholar 

  15. Toth-Heyn P, Drukker A, Guignard JP. The stressed neonatal kidney: from pathophysiology to clinical management of neonatal vasomotor nephropathy. Pediatr Nephrol. 2000;14(3):227–39.

    Article  CAS  PubMed  Google Scholar 

  16. Nangaku M, Fujita T. Activation of the renin–angiotensin system and chronic hypoxia of the kidney. Hypertens Res. 2008;31(2):175–84.

    Article  PubMed  Google Scholar 

  17. Mao C, Hou J, Ge J, Hu Y, Ding Y, Zhou Y, Zhang H, Xu Z, Zhang L. Changes of renal AT1/AT2 receptors and structures in ovine fetuses following exposure to long-term hypoxia. Am J Nephrol. 2010;31(2):141–50.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Tekin N, Dinleyici EC, Aksit MA, Kural N, Erol K. Plasma and urinary endothelin-1 concentrations in asphyxiated newborns. Neuro Endocrinol Lett. 2007;28(3):284–8.

    CAS  PubMed  Google Scholar 

  19. Seidl R, Stöckler-Ipsiroglu S, Rolinski B, Kohlhauser C, Herkner KR, Lubec B, Lubec G. Energy metabolism in graded perinatal asphyxia of the rat. Life Sci. 2000;67(4):421–35.

    Article  CAS  PubMed  Google Scholar 

  20. Di Sole F. Adenosine and renal tubular function. Curr Opin Nephrol Hypertens. 2008;17(4):399–407.

    Article  PubMed  Google Scholar 

  21. Chen DP, Yao YJ, Chen J. Function of actin in renal tubular epithelial cell of newborn swine during ATP deficiency. Sichuan Da Xue Xue Bao Yi Xue Ban. 2004;35(4):503–5.

    CAS  PubMed  Google Scholar 

  22. Basu P, Som S, Chodouri N, Das H. Correlation between Apgar score and urinary uric acid to creatinine in perinatal asphyxia. Indian J Clin Biochem. 2008;23(4):361–4.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Mohd A, Ahmed N, Chowdhary J, Saif RU. Acute renal failure: nephrosonographic findings in asphyxiated neonates. Saudi J Kidney Dis Transpl. 2011;22(6):1187–92.

    Google Scholar 

  24. Antonucci R, Fanos V. NSAIDs, prostaglandins and the neonatal kidney. J Matern Fetal Neonatal Med. 2009;22 Suppl 3:23–6.

    Article  CAS  PubMed  Google Scholar 

  25. Antonucci R, Cuzzolin L, Arceri A, Dessì A, Fanos V. Changes in urinary PGE2 after ibuprofen treatment in preterm infants with patent ductus arteriosus. Eur J Clin Pharmacol. 2009;65(3):223–30.

    Article  CAS  PubMed  Google Scholar 

  26. Antonucci R, Cuzzolin L, Arceri A, Fanos V. Urinary prostaglandin E2 in the newborn and infant. Prostaglandins Other Lipid Mediat. 2007;84(1–2):1–13. Epub 2007 May 6.

    Article  CAS  PubMed  Google Scholar 

  27. Cisse M, Ilunga S, Benmoulai I, Mariette JB. Acute renal insufficiency in severe prematurity. Arch Pediatr. 2013;20(2):171–5.

    Article  CAS  PubMed  Google Scholar 

  28. Kojima T, Kobayashi T, Matsuazaki S, Iwase S, Kobayashi Y. Effects of perinatal asphyxia and myoglobinuria on development of acute, neonatal renal failure. Arch Dis Child. 1985;60:908–12.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Fanos V, Cuzzolin L. Causes and manifestation of nephrotoxicity. In: Geary DF, Shaefer F, editors. Comprehensive pediatric nephrology. Philadelphia: Mosby Elsevier; 2008.

    Google Scholar 

  30. Yu B, Li S, Yao Y, Lin Z. Changes in beta(1) integrin in renal tubular epithelial cells after intrauterine asphyxia of rabbit pups. J Perinat Med. 2009;37(1):59–65.

    Article  CAS  PubMed  Google Scholar 

  31. Kaur S, Jain S, Saha A, Chawla D, Parmar VR, Basu S, Kaur J. Evaluation of glomerular and tubular renal function in neonates with birth asphyxia. Ann Trop Paediatr. 2011;31(2):129–34.

    Article  CAS  PubMed  Google Scholar 

  32. Askenazi D. Are we ready for the clinical use of novel acute kidney injury biomarkers? Pediatr Nephrol. 2012;27(9):1423–5.

    Article  PubMed  Google Scholar 

  33. Cataldi L, Mussap M, Bertelli L, Ruzzante N, Fanos V, Plebani M. Cystatin C in healthy women at term pregnancy and in their infant newborns: relationship between maternal and neonatal serum levels and reference values. Am J Perinatol. 1999;16(6):287–95.

    Article  CAS  PubMed  Google Scholar 

  34. Mussap M, Fanos V, Pizzini C, Marcolongo A, Chiaffoni G, Plebani M. Predictive value of amniotic fluid cystatin C levels for the early identification of fetuses with obstructive uropathies. BJOG. 2002;109(7):778–83.

    Article  CAS  PubMed  Google Scholar 

  35. Puddu M, Podda MF, Mussap M, Tumbarello R, Fanos V. Early detection of microalbuminuria and hypertension in children of very low birthweight. J Matern Fetal Neonatal Med. 2009;22(2):83–8.

    Article  CAS  PubMed  Google Scholar 

  36. Zaffanello M, Franchini M, Fanos V. Is serum cystatin-C a suitable marker of renal function in children? Ann Clin Lab Sci. 2007;37:233–40.

    CAS  PubMed  Google Scholar 

  37. Sarafidis K, Tsepkentzi E, Agakidou E, Diamanti E, Taparkou A, Soubasi V, Papachristou F, Drossou V. Serum and urine acute kidney injury biomarkers in asphyxiated neonates. Pediatr Nephrol. 2012;27(9):1575–82.

    Article  PubMed  Google Scholar 

  38. Dursun A, Okumus N, Zenciroglu A. Ischemia-modified albumin (IMA): could it be useful to predict perinatal asphyxia? J Matern Fetal Neonatal Med. 2012;25(11):2401–5.

    Article  CAS  PubMed  Google Scholar 

  39. Mussap M, Noto A, Cibecchini F, Fanos V. The importance of biomarkers in neonatology. Semin Fetal Neonatal Med. 2013;18(1):56–64. doi:10.1016/j.siny.2012.10.006. Epub 2012 Nov 17.

    Article  CAS  PubMed  Google Scholar 

  40. Argyri I, Xanthos T, Varsami M, Aroni F, Papalois A, Dontas I, Fanos V, Iacovidou N. The role of novel biomarkers in early diagnosis and prognosis of acute kidney injury in newborns. Am J Perinatol. 2013;30:347–52.

    Article  PubMed  Google Scholar 

  41. Fanos V, Antonucci R, Zaffanello M, Mussap M. Neonatal drug induced nephrotoxicity: old and next generation biomarkers for early detection and management of neonatal drug-induced nephrotoxicity, with special emphasis on uNGAL and on metabolomics. Curr Med Chem. 2012;19(27):4595–605.

    Article  CAS  PubMed  Google Scholar 

  42. Noto A, Cibecchini F, Fanos V, Mussap M. NGAL and Metabolomics: the single biomarker to unreveal the metabolome alterations in kidney injury. Biomed Res Int. 2013;2013:612032.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  43. Solberg R, Enot D, Deigner HP, Koal T, Scholl-Bürgi S, Saugstad OD, Keller M. Metabolomic analyses of plasma reveals new insights into asphyxia and resuscitation in pigs. PLoS One. 2010;5:e9606.

    Article  PubMed Central  PubMed  Google Scholar 

  44. Atzori L, Xanthos T, Barberini L, Antonucci R, Murgia F, Lussu M, Aroni F, Varsami M, Papalois A, Lai A, D’Aloja E, Iacovidou N, Fanos V. A metabolomic approach in an experimental model of hypoxia reoxygenation in newborn piglets: urine predicts outcome. J Matern Fetal Neonatal Med. 2010;23 Suppl 3:134–7.

    Article  CAS  PubMed  Google Scholar 

  45. Beckstrom AC, Humston EM, Snyder LR, Synovec RE, Juul SE. Application of comprehensive twodimensional gas chromatography with time of flight mass spectrometry method to identify potential biomarkers of perinatal asphyxia in a nonhuman primate model. J Chromatogr A. 2011;1218(14):1899–906.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  46. Puddu M, Fanos V, Podda F, Zaffanello M. The kidney from prenatal to adult life: perinatal programming and reduction of number of nephrons during development. Am J Nephrol. 2009;30(2):162–70.

    Article  PubMed  Google Scholar 

  47. Wilkinson L, Chiu H, Rumballe B, Georgas K, Ju A, Moritz K, Little M. The effect of hypoxia on the development of the kidney. In: 11th international workshop on developmental nephrology, New York, Oral Presentation Abstract P-29; 2010. p. 83.

    Google Scholar 

  48. Yzydorczyk C, Comte B, Cambonie G, Lavoie JC, Germain N, Ting Shun Y, Wolff J, Deschepper C, Touyz RM, Lelièvre-Pegorier M, Nuyt AM. Neonatal oxygen exposure in rats leads to cardiovascular and renal alterations in adulthood. Hypertension. 2008;52(5):889–95.

    Article  CAS  PubMed  Google Scholar 

  49. Stojanović V, Vučković N, Spasojević S, Barišić N, Doronjski A, Zikić D. The influence of EPO and hypothermia on the kidneys of rats after perinatal asphyxia. Pediatr Nephrol. 2012;27(1):139–44.

    Article  PubMed  Google Scholar 

  50. Puxeddu E, Gerosa C, Fanni D, Locci A, Bronshtein V, Cai C, Bronshtein M, Valencia G, Beharry KD, Aranda J. Acute renal changes in asphyxiated rats following therapeutic hypothermia. In: Selected abstracts of the 8th international workshop on neonatology, Cagliari, 24–27 October 2012. J Pediatr Neonatal Individual Med. 2012;1(1):111.

    Google Scholar 

  51. Ellery SJ, Ireland Z, Kett MM, Snow R, Walker DW, Dickinson H. Creatine pretreatment prevents birth asphyxia-induced injury of the newborn spiny mouse kidney. Pediatr Res. 2013;73(2):201–8. doi:10.1038/pr.2012.174. Epub 2012 Nov 22.

    Article  CAS  PubMed  Google Scholar 

  52. Lee TF, Liu JQ, Li YQ, Nasim K, Chaba T, Bigam DL, Cheung PY. Improved renal recovery with postresuscitation N-acetylcysteine treatment in asphyxiated newborn pigs. Shock. 2011;35(4):428–33. doi:10.1097/SHK.0b013e3181fffec2.

    Article  CAS  PubMed  Google Scholar 

  53. Subramanian S, Agarwal R, Deorari A, Paul V, Bagga A. Acute renal failure in neonates. Indian J Pediatr. 2008;75(4):385–91.

    Google Scholar 

  54. Guignard JP, Gouyon JB. Glomerular filtration rate in neonates. In: Oh W, Guignard JP, Baumgart S, editors. Nephrology and fluid/electrolyte physiology. Philadelphia: Elsevier; 2008. p. 79–96.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria Cagliari, Strada Statale 554, bivio Sestu, Cagliari, 09042, Italy

    Vassilios Fanos M.D.

  2. Department of Surgery, University of Cagliari, Strada Statale 554, bivio Sestu, Cagliari, 09042, Italy

    Vassilios Fanos M.D.

  3. Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria Cagliari, Cagliari, Italy

    Angelica Dessì M.D., Melania Puddu M.D. & Giovanni Ottonello M.D.

Authors
  1. Vassilios Fanos M.D.
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  2. Angelica Dessì M.D.
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  3. Melania Puddu M.D.
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  4. Giovanni Ottonello M.D.
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Corresponding author

Correspondence to Vassilios Fanos M.D. .

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Editors and Affiliations

  1. Department of Surgical Sciences, Division of Pathology, Azienda Ospedaliera Universitaria and University of Cagliari, Cagliari, Italy and Temple University, Philadelphia, Pennsylvania, USA

    Gavino Faa

  2. Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, and Department of Surgery, Azienda Ospedaliera Universitaria Cagliari, Cagliari, Italy and University of Cagliari, Cagliari, Italy, Cagliari, Italy

    Vassilios Fanos

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Fanos, V., Dessì, A., Puddu, M., Ottonello, G. (2014). Perinatal Asphyxia and Kidney Development. In: Faa, G., Fanos, V. (eds) Kidney Development in Renal Pathology. Current Clinical Pathology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0947-6_6

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  • DOI: https://doi.org/10.1007/978-1-4939-0947-6_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-0946-9

  • Online ISBN: 978-1-4939-0947-6

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